Haptoglobin Groups and Leukemia

Fröhlander, Nils

doi:10.1159/000153486

Cited by 9 publications

(9 citation statements)

References 3 publications

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“…In contrast, ahaptoglobinemia was more frequent among these patients, in agreement with the findings of Fröhlander (1984). Calderoni et al (2006) investigated the frequency of Hp phenotypes in patients suffering from indeterminate, chronic cardiac, chronic digestive or chronic 'combined' (i.e.…”

Section: Association Studies In Brazilian Populationssupporting

confidence: 79%

“…A significantly higher frequency of the Hp1-1 phenotype was observed among leukemia patients with ALL, AML and CML, but not among those with CLL. Fröhlander (1984) found no association between Hp phenotypes and leukemia but observed a significantly higher frequency of ahaptoglobinemia in these patients. A low Hp2-2 frequency has been observed in patients with IgA myeloma (Germenis et al, 1983).…”

Section: Cancercontrasting

confidence: 59%

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Polymorphism of human haptoglobin and its clinical importance

2008

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Haptoglobin (Hp) is a plasma glycoprotein, the main biological function of which is to bind free hemoglobin (Hb) and prevent the loss of iron and subsequent kidney damage following intravascular hemolysis. Haptoglobin is also a positive acute-phase protein with immunomodulatory properties. In humans, the HP locus is polymorphic, with two codominant alleles (HP1 and HP2) that yield three distinct genotypes/phenotypes (Hp1-1, Hp2-1 and Hp2-2). The corresponding proteins have structural and functional differences that may influence the susceptibility and/or outcome in several diseases. This article summarizes the available data on the structure and functions of Hp and the possible effects of Hp polymorphism in a number of important human disorders.

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Section: Association Studies In Brazilian Populationssupporting

confidence: 79%

Section: Cancercontrasting

confidence: 59%

Polymorphism of human haptoglobin and its clinical importance

2008

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“…Earlier studies on the possible associa tion between serum HP and leukaemia [Latner and Zaki, I960;Galatius-Jensen, 1962;Peacock, 1966;Papiha et a!., 1974;Naik et al, 1979 andFrohlander, 1984] had reported an increased frequency of HP1 in patients compared with controls, but in only two [Latner and Zaki, 1960;Peacock, 1966] did it reach the level of sig nificance.…”

Section: Introductionmentioning

confidence: 95%

Associations between the Two Serum Proteins Haptoglobin and Transferrin and Leukaemia

Mitchell

Carzino

Janardhana³

1988

Hum Hered

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Haptoglobin and transferrin (TF) types were determined for 134 patients with leukaemia of the four most common types: acute lymphocytic (ALL), chronic lymphocytic (CLL), acute myelocytic (AML) and chronic myelocytic leukaemia (CML). The phenotype HPl was found to have an increased incidence in the total patient group due to an increased incidence in those with AML, ALL and CML compared with controls, but not in those with CLL. Although tests of association applied to each of the samples of the four common types of leukaemia produced no significant χ2 values, they did indicate that the relative incidence (RI) was just under 2 for the groupings of the acute forms ALL and AML, the myelocytic forms AML and CML and for the combination of ALL, AML and CML, respectively. All these associations were statistically significant (p < 0.05). Analysis of TF subtypes and leukaemia indicated a significantly increased frequency of TF C1C1 among leukaemia patients compared with controls (p < 0.005). Analysis of the samples of each of the four common types suggested that while the RI was raised in all but ALL patients, the association was significant only in AML patients (p < 0.05). However, when the two myelocytic types were combined the RI was 2.3 and the association was highly significant (p < 0.005). No such association could be detected in the lymphocytic forms.

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“…How ever, only the three main phenotypes have been considered in such studies [Frohlander, 1984;Matsuyama and Joseph, 1984;Norrgard et al, 1984], Genes influence lipid levels and athero sclerosis risk [Berg, 1983[Berg, , 1985 and the identification of the individual genes in question is an important task. Sing and Orr [1976] analysed the effect of the main Hp types on total cholesterol level and found that females with genotype Hp2-2 had on average a 4.22mg/100ml (0.11mmol/l) higher cholesterol level than females possessing the Hpl gene.…”

Section: Introductionmentioning

confidence: 99%

Effect of Haptoglobin Subtypes on Serum Lipid Levels

Børresen¹,

Leren

Berg

et al. 1987

Hum Hered

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Haptoglobin (Hp) subtypes were analysed by two-dimensional high-resolution gel electrophoresis in 81 Norwegian individuals with moderate hypercholesterolemia and in 316 Norwegian control subjects. The frequencies of the genes Hp2SS and Hp2SF were higher in individuals with hypercholesterolemia than in controls but the differences did not reach statistical significance (p = 0.087). Within the control population, no effect of the different Hp subtypes was found on total serum cholesterol, triglycerides or high-density lipoprotein (HDL) cholesterol. However, in the controls a significantly higher frequency of Hp2–2 types was found among those with HDL cholesterol values in the upper quartile as compared to those with HDL cholesterol in the lower quartile. A similar phenomenon was not uncovered in analyses of total serum cholesterol or triglycerides. Our results are in agreement with others which indicate that genes belonging to the Hp polymorphism play a role in predicting an individual’s total serum cholesterol level. However, our data indicate that the cholesterol effect is on the HDL rather than on the total cholesterol level.

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Haptoglobin Groups and Leukemia

Cited by 9 publications

References 3 publications

Polymorphism of human haptoglobin and its clinical importance

Polymorphism of human haptoglobin and its clinical importance

Associations between the Two Serum Proteins Haptoglobin and Transferrin and Leukaemia

Effect of Haptoglobin Subtypes on Serum Lipid Levels

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