Haptoglobin phenotype as a predictive factor of mortality in diabetic haemodialysis patients

Burbea, Zvi; Nakhoul, Farid; Zoabi, Roaa; Hochberg, Irit; Levy, Nina S.; Benchetrit, Sidney; Weissgarten, Joshua; Tovbin, David; Knecht, Aaron; Iaina, Adrian; Herman, Michal; Kristal, Batya; Levy, Andrew P.

doi:10.1258/0004563042466758

Cited by 19 publications

(15 citation statements)

References 15 publications

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“…After screening the headings and abstracts, five studies finally met the inclusion criteria [15–17,21,13]. For the interventional meta-analysis, eight records were retrieved using the electronic search strategy of this review, of which one [15] was included.…”

Section: Resultsmentioning

confidence: 99%

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Haptoglobin genotype and cardiovascular outcomes in diabetes mellitus — natural history of the disease and the effect of vitamin E treatment. Meta-analysis of the medical literature

Vardi

Blum

Levy

2012

European Journal of Internal Medicine

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Background Diabetes mellitus carries a high risk for vascular events. Diabetics with different haptoglobin (Hp) types may carry different risk profiles, and may respond differently to vitamin E treatment. We aim to summarize the evidence about cardiovascular risk in diabetic patients, according to their Hp type, and the effect of vitamin E treatment on these sub-groups. Methods We searched MEDLINE and on-going trials’ databases until February 2011; gray literature; reference lists of identified articles; and experts. Two investigators screened and selected studies that prospectively followed cardiovascular outcomes in diabetic patients with different Hp types (natural history analysis), and randomized controlled trials reporting the effect of vitamin E on cardiovascular outcomes in diabetics, in which Hp typing was performed (interventional analysis). Results Five and three studies, comprising 1829 and 2110 patients, were eligible for the natural history and the interventional analyses, respectively. The percentage of diabetic patients experiencing non-fatal MI, stroke, or cardiovascular death was significantly higher in the Hp 2–2 population (odds ratio (OR) 2.03 (95% confidence interval (CI) 1.46 to 2.81)). In patients with Hp 2–2 genotype, the OR for a combined endpoint was 0.66 in favor of the vitamin E treated group (95% CI 0.48 to 0.9). This effect was not shown in other Hp types. Conclusion Hp type 2–2 carries a high risk of cardiovascular events in diabetic patients. A pharmacogenomic approach towards treatment of diabetic patients with vitamin E may be warranted.

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Section: Resultsmentioning

confidence: 99%

“…A post hoc exclusion of studies assessing specific medical scenarios such as heart failure and acute coronary events [16,17,21] did not affect the robustness of the results.…”

Section: Outcome Measuresmentioning

confidence: 99%

Haptoglobin genotype and cardiovascular outcomes in diabetes mellitus — natural history of the disease and the effect of vitamin E treatment. Meta-analysis of the medical literature

Vardi

Blum

Levy

2012

European Journal of Internal Medicine

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“…There is evidence establishing Hp 2-2 as a predictor of CVD in diabetes mellitus [20, 21]. However, results are inconsistent regarding Hp genotypes and cardiovascular mortality in patients with CKD [22, 23]. A study in patients with ischemic heart disease (IHD) revealed a positive association between low HRV and Hp 2-2 [24].…”

Section: Introductionmentioning

confidence: 99%

Haptoglobin Genotype and Risk Markers of Cardiovascular Disease in Patients with Chronic Kidney Disease

Strandhave

Svensson

Krarup

et al. 2013

International Journal of Nephrology

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Sudden cardiac death and atherosclerosis have a major impact on cardiovascular mortality in chronic kidney disease (CKD). Inflammation with elevated high-sensitive C-reactive protein (hs-CRP) is involved in both sudden cardiac death and atherosclerosis, and decreased heart rate variability (HRV) is a predictor of both sudden cardiac death and atherosclerosis. Haptoglobin (Hp) is characterised by three genotypes (1-1, 2-1, and 2-2) with different antioxidant abilities. The aim was to examine whether HRV and hs-CRP were associated with Hp genotype in CKD patients. Fifty-six patients with CKD stage 2–5 were included. Hp genotype was determined by high-performance liquid chromatography. HRV was analysed from the 24 h Holter recordings. Hs-CRP was measured using an immunoturbidimetric assay. The results show that the HRV indices SDNN and SDANN were significantly lower in the Hp 2-2 patients (P = 0.02 and 0.04, resp.). In an adjusted linear regression model, Hp 2-2 was associated with both SDNN (P = 0.005) and SDANN (P = 0.01). Hs-CRP was higher in the Hp 2-2 patients (P = 0.002). In an adjusted linear regression model, the association between Hp 2-2 and hs-CRP remained significant (P = 0.003). In conclusion, a negative association was observed between Hp 2-2 and HRV, and Hp 2-2 was positively associated with hs-CRP in CKD patients.

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“…An intermediate risk of CVD is associated with the Hp2/1 phenotype. [30][31][32] Furthermore, transgenic Hp2/2 mice on an apoEϪ/Ϫ background have more iron deposits and lipid peroxidation products as well as macrophage accumulation in atherosclerotic lesions compared with apoEϪ/Ϫ controls that have wild-type mouse Hp1/1 genotype. 33 Even intact erythrocytes can be a source of catalytically active heme.…”

Section: Low-density Lipoprotein Oxidation By Hemementioning

confidence: 99%

Lipoprotein Oxidation and Modification

Miller¹,

Tsimikas²

2009

Clinical Lipidology

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Haptoglobin phenotype as a predictive factor of mortality in diabetic haemodialysis patients

Abstract: Hp phenotype may be useful in the risk stratification algorithm and management of DDPs.

Cited by 19 publications

References 15 publications

Haptoglobin genotype and cardiovascular outcomes in diabetes mellitus — natural history of the disease and the effect of vitamin E treatment. Meta-analysis of the medical literature

Haptoglobin genotype and cardiovascular outcomes in diabetes mellitus — natural history of the disease and the effect of vitamin E treatment. Meta-analysis of the medical literature

Haptoglobin Genotype and Risk Markers of Cardiovascular Disease in Patients with Chronic Kidney Disease

Lipoprotein Oxidation and Modification

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