Haptoglobin polymorphism and diabetic retinopathy in Brazilian patients

Wobeto, Vânia Pereira Albuquerque; Rosim, Endrigo Torezan; Melo, Mônica Barbosa de; Calliari, Luís Eduardo; Sonati, María de Fátima

doi:10.1016/j.diabres.2006.12.018

Cited by 15 publications

(14 citation statements)

References 14 publications

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“…The Hp *1 allele frequency of 41.1% that we found was similar to those reported from other urban Brazilian populations in São Paulo State (46%) (Wobeto et al, 2007) and Eurodescendants from Porto Alegre (41.4%) (Tondo et al, 1963), and the phenotype frequencies were close to those found by Wobeto et al, 2007. The allele frequencies that we observed were similar to those observed for the European population of Australia (Lai et al, 1986) and among Germans (Kruger and Puschel, 1993).…”

Section: Discussionsupporting

confidence: 77%

Antioxidant effect of haptoglobin phenotypes against DNA damage induced by hydrogen peroxide in human leukocytes

Moreira

Miranda-Vilela²,

Silva³

et al. 2009

Genet. Mol. Res.

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ABSTRACT. Human haptoglobin is classified into three major phenotypes: Hp1-1, Hp2-1 and Hp2-2; there are two autosomal alleles Hp . Haptoglobin acts as an antioxidant, preventing hemoglobin-driven oxidative damage. We used the comet assay to examine oxidative damage to DNA induced by hydrogen peroxide in human leukocytes; we also looked for differences in the antioxidant capacity of haptoglobin subtypes. Haptoglobin genotypes were determined through allele-specific polymerase chain reaction, visualized on a polyacrylamide gel. The Hp1-1 genotype had the least DNA damage; this indicates that Hp alleles differ in their protective effects against oxidative damage. Among Hp *1 alleles, Hp *1F was the most protective.

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Section: Discussionsupporting

confidence: 77%

Antioxidant effect of haptoglobin phenotypes against DNA damage induced by hydrogen peroxide in human leukocytes

Moreira

Miranda-Vilela²,

Silva³

et al. 2009

Genet. Mol. Res.

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“…Zaccariotto et al (2006) found no significant influence of the Hp genotypes on the iron status, negative and positive acute-phase serum protein concentrations, T-CD4+ lymphocyte counts and viral loads in HIV-seropositive patients and healthy HIV-seronegative individuals in southeastern Brazil. Similarly, Wobeto et al (2007) observed no significant relationship between the frequency of the Hp genotype in type 1 and type 2 DM patients with and without diabetic retinopathy.…”

Section: Association Studies In Brazilian Populationsmentioning

confidence: 67%

Polymorphism of human haptoglobin and its clinical importance

2008

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Haptoglobin (Hp) is a plasma glycoprotein, the main biological function of which is to bind free hemoglobin (Hb) and prevent the loss of iron and subsequent kidney damage following intravascular hemolysis. Haptoglobin is also a positive acute-phase protein with immunomodulatory properties. In humans, the HP locus is polymorphic, with two codominant alleles (HP1 and HP2) that yield three distinct genotypes/phenotypes (Hp1-1, Hp2-1 and Hp2-2). The corresponding proteins have structural and functional differences that may influence the susceptibility and/or outcome in several diseases. This article summarizes the available data on the structure and functions of Hp and the possible effects of Hp polymorphism in a number of important human disorders.

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“…Obesity was defined as body mass index (BMI) 30 kg/m 2 28 . Diabetic retinopathy (DR) and diabetic nephropathy (DN) had been previously investigated in these patients 21,29 . Serum creatinine was measured by a modified Jaffé method, and the reference values for males and females were ≤1.20 mg/dL and ≤0.90 mg/dL, respectively 30 .…”

Section: Methodsmentioning

confidence: 99%

“…After obtaining approval from the Local Ethics Committee, we collected peripheral blood samples from 120 T2DM patients with at least 10 years of disease followed at the Endocrinology Section of Hospital de Clínicas da UNICAMP in Campinas who had previously been investigated in another study 21 in the state of São Paulo, southeastern Brazil. All patients signed an Informed Consent Form.…”

Section: Methodsmentioning

confidence: 99%