Harmine exerts anxiolytic effects by regulating neuroinflammation and neuronal plasticity in the basolateral amygdala

Zheng, Zhi-Heng; Lin, Xing-Cheng; Lu, Ying; Cao, Shi-Rui; Liu, Xu-Kai; Dong, Lin; Yang, Fan-Hua; Zhang, Yang-Bo; Tu, Jiyuan; Pan, Bing‐Xing; Hu, Ping; Zhang, Wen-Hua

doi:10.1016/j.intimp.2023.110208

Cited by 6 publications

(2 citation statements)

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“…Furthermore, this understanding facilitates the identification of new pharmacological targets and promising therapeutic approaches, such as small molecules, growth factors, or non-coding RNAs. For instance, antidepressants that enhance neurotrophic factor production or anxiolytics that suppress neuroinflammation can be prescribed, combining the effects of 10.3389/fnmol.2024.1361764 Frontiers in Molecular Neuroscience 14 frontiersin.org symptomatic and pathogenetic therapies (Nibuya et al, 1995;Zheng et al, 2023). However, elucidating the contribution and functional significance of specific genes and their variants in neural tissue development warrants further investigation using cellular or animal models, which is now becoming increasingly accessible due to the possibilities of modern genetic and cellular technologies (Białoń and Wąsik, 2022;Dougnon and Matsui, 2022;Karagyaur et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Morphogenetic theory of mental and cognitive disorders: the role of neurotrophic and guidance molecules

Primak,

Bozov,

Rubina

et al. 2024

Front. Mol. Neurosci.

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Mental illness and cognitive disorders represent a serious problem for the modern society. Many studies indicate that mental disorders are polygenic and that impaired brain development may lay the ground for their manifestation. Neural tissue development is a complex and multistage process that involves a large number of distant and contact molecules. In this review, we have considered the key steps of brain morphogenesis, and the major molecule families involved in these process. The review provides many indications of the important contribution of the brain development process and correct functioning of certain genes to human mental health. To our knowledge, this comprehensive review is one of the first in this field. We suppose that this review may be useful to novice researchers and clinicians wishing to navigate the field.

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Section: Discussionmentioning

confidence: 99%

Morphogenetic theory of mental and cognitive disorders: the role of neurotrophic and guidance molecules

Primak,

Bozov,

Rubina

et al. 2024

Front. Mol. Neurosci.

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“…[28][29][30] Previous studies find that cantaloupe bases have a wide range of biological activities, such as antibacterial, anti-Parkinsonism and anti-tumor. [31][32][33][34][35] Harmine can regulate the expression of PPARγ through inhibiting the Wnt signaling pathway, enhance insulin sensitivity, and increase pancreatic βcell replication by the inhibition of DYRK1 A. Some β-carboline alkaloids act as AChE and Aβ inhibitors for the treatment of Alzheimer's disease, but the detailed action mechanism is not well interpreted.…”

Section: Introductionmentioning

confidence: 99%

β‐Carboline Alkaloids Resist the Aggregation and Cytotoxicity of Human Islet Amyloid Polypeptide

et al. 2023

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β‐carboline alkaloids have a variety of pharmacological activities, such as anti‐tumor, antibiosis and anti‐diabetes. Harmine and harmol are two structurally similar β‐carbolines that occur in many medicinal plants. In this work, we chose harmine and harmol to impede the amyloid fibril formation of human islet amyloid polypeptide (hIAPP) associated with type 2 diabetes mellitus (T2DM), by a series of physicochemical and biochemical methods. The results indicate that harmine and harmol effectively prevent peptide fibrillation and alleviate toxic oligomer species. In addition, both small molecules exhibit strong binding affinities with hIAPP mainly through hydrophobic and hydrogen bonding interactions, reducing the cytotoxicity induced by hIAPP. Their distinct binding pattern with hIAPP is closely linked to the molecular configuration of two small molecules, affecting their ability to impede peptide aggregation. The study is of great significance for the application and development of β‐carboline alkaloids against T2DM.

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The unpaved road of ayahuasca, a psychoactive brew, as a treatment for neuropathic pain: A review of mechanistic insights and clinical prospects

dos Santos,

Reis,

Nucci

et al. 2024

Brain Behavior and Immunity Integrative

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Harmine exerts anxiolytic effects by regulating neuroinflammation and neuronal plasticity in the basolateral amygdala

Cited by 6 publications

References 50 publications

Morphogenetic theory of mental and cognitive disorders: the role of neurotrophic and guidance molecules

Morphogenetic theory of mental and cognitive disorders: the role of neurotrophic and guidance molecules

β‐Carboline Alkaloids Resist the Aggregation and Cytotoxicity of Human Islet Amyloid Polypeptide

The unpaved road of ayahuasca, a psychoactive brew, as a treatment for neuropathic pain: A review of mechanistic insights and clinical prospects

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