2020
DOI: 10.1093/geroni/igaa057.530
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HARMONY Study: Pimavanserin Significantly Prolongs Time to Relapse of Dementia-Related Psychosis

Abstract: Dementia-related psychosis (DRP) is common among patients with Alzheimer’s disease (AD), Parkinson’s disease (PD), dementia with Lewy bodies (DLB), frontotemporal dementia (FTD), and vascular dementia (VaD) and is associated with poor outcomes. HARMONY (NCT03325556) was a Phase 3, placebo-controlled, randomized, relapse-prevention study evaluating the efficacy and safety of pimavanserin for treating hallucinations and delusions associated with DRP. Patients with dementia and moderate-severe psychosis received … Show more

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“…Unlike other atypical antipsychotics, pimavanserin has no clinically significant antagonism of dopaminergic, muscarinic, or histaminergic receptors. 52 Evidence 53 indicates that pimavanserin may decrease hallucinations and delusions in patients with AD, PD dementia, VaD, DLB, and FTD (including among nursing home residents with severe psychotic symptoms 54 ), but it is not FDA-approved for this indication.…”
Section: Guidance On Atypical Antipsychotics In Drpmentioning
confidence: 99%
“…Unlike other atypical antipsychotics, pimavanserin has no clinically significant antagonism of dopaminergic, muscarinic, or histaminergic receptors. 52 Evidence 53 indicates that pimavanserin may decrease hallucinations and delusions in patients with AD, PD dementia, VaD, DLB, and FTD (including among nursing home residents with severe psychotic symptoms 54 ), but it is not FDA-approved for this indication.…”
Section: Guidance On Atypical Antipsychotics In Drpmentioning
confidence: 99%