2024
DOI: 10.21203/rs.3.rs-4775433/v1
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Harnessing Theta-Gamma Coupled Brainwave Using Ultrasound for Spinal Astrocyte Revitalization and Sustained Neuropathic Pain Relief

Joo Min Park,
Tien Phan,
Ho Jeong Kim
et al.

Abstract: Ultrasound stimulation is a promising non-invasive method for pain treatment, but comprehending its long-lasting impact and mechanisms remains challenging. Here, we investigate the neuromodulation effects of patterned ultrasound, focusing on spinal astrocytes in a partial sciatic nerve crush injury (PCI) model. Low-intensity continuous theta burst ultrasound stimulation with gamma bursts (LI-cTBUS) provides significant pain relief during and after application. LI-cTBUS enhances extracellular BDNF uptake by spi… Show more

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