Hashimoto's Encephalopathy: Back to Square One

Delgado‐García, Guillermo; Balint, Bettina

doi:10.1002/mdc3.13012

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…However, antithyroid antibodies can be seen in the normal population also. Recent articles by Mattozzi et al 2 and Delgado‐García and Balint 3 discussed about the controversies surrounding HE. With recent advancements and new revelations in immunology and autoimmune neurological disorders, in future, this entity may be amalgamated with other disorders, but for the time being, any clinical syndrome with very high anti-TPO antibodies, characteristic clinical features, and good response to steroids is regarded as HE.…”

Section: Discussionmentioning

confidence: 99%

Orthostatic Myoclonic Jerks in a Case of Hashimoto's Encephalopathy

Singh

Sidhu

2022

JNRP

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Hashimoto's encephalopathy (HE) is an uncommon syndrome with the characteristic triad of positive antithyroid antibodies (most commonly antibodies to thyroid peroxidase), response to steroids, and clinical picture presenting either as stroke-like pattern of focal neurological deficit or slowly progressive cognitive impairment. Myoclonus or tremors, seizures, and psychosis are other associated features which can be seen in HE. Herein, we report a girl with an uncommon presentation of orthostatic axial and myoclonic jerks in bilateral lower limbs in a case of HE.

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Section: Discussionmentioning

confidence: 99%

Orthostatic Myoclonic Jerks in a Case of Hashimoto's Encephalopathy

Singh

Sidhu

2022

JNRP

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“…TPO antibodies have been associated with encephalopathy, then often referred to as Hashimoto's encephalopathy (HE). However, antithyroid antibodies can also be found in healthy children and are at present not considered pathogenic in HE; they are instead regarded as markers of a general susceptibility to autoimmunity [31,32] Before antimanic treatment is initiated, a differential diagnostic reasoning is essential, and somatic comorbidity such as anti-NMDAR encephalitis or HE must be ruled out. A subcommittee of the Autoimmune Encephalitis International Working Group has recently proposed an algorithm and redefined the criteria for autoimmune encephalitis in children [31].…”

Section: Discussionmentioning

confidence: 99%

Acute Mania and Catatonia in a Teenager Successfully Treated with Electroconvulsive Therapy and Diagnosed with Turner Syndrome and Bipolar Disorder

Rödström

Johansson

Bäckström³

et al. 2021

Case Reports in Psychiatry

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Background. Turner syndrome (TS) is an X-linked chromosomal abnormality with a global prevalence of 1/2000 live-born girls. The physiological symptoms of TS have been thoroughly characterized, but only a few studies have described associated psychiatric symptoms. We report a case of an adolescent girl who presented with acute mania with psychotic features and was successfully treated with electroconvulsive therapy (ECT). She was subsequently diagnosed with bipolar syndrome and TS. Case Presentation. A 17-year-old girl presented to us with manic symptoms, including disorganized speech, auditory hallucinations, and affect lability. Initially, she was treated with antipsychotics and benzodiazepines, whereby the positive affective symptoms declined. However, the psychotic symptoms progressed, and she developed a catatonic state. ECT was started 6 days after admission, with improvement after two treatments. When ECT was tapered after seven sessions, she relapsed, and the treatment was extended to twelve sessions, with successful outcome. Following discharge, she was diagnosed with TS with partial loss on one of the X-chromosomes (46X, del (X)(p21)), which might have contributed to the development of her sudden acute manic episode. Conclusions. This case demonstrates for the first time that ECT may be a safe and efficient treatment strategy for acute mania in adolescents with concomitant TS and that severely affected adolescents may require a prolonged series with gradual tapering of ECT. The present case also demonstrates a possible association between TS and bipolar syndrome and that the clinical presentation of a manic episode in a patient with this comorbidity could be more complex and the treatment response slower.

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Hashimoto's Encephalopathy: Back to Square One

Cited by 2 publications

References 5 publications

Orthostatic Myoclonic Jerks in a Case of Hashimoto's Encephalopathy

Orthostatic Myoclonic Jerks in a Case of Hashimoto's Encephalopathy

Acute Mania and Catatonia in a Teenager Successfully Treated with Electroconvulsive Therapy and Diagnosed with Turner Syndrome and Bipolar Disorder

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