Hashimoto's Thyroiditis Affects Symptom Load and Quality of Life Unrelated to Hypothyroidism: A Prospective Case–Control Study in Women Undergoing Thyroidectomy for Benign Goiter

Ott, Johannes; Promberger, Regina; Kober, F.; Neuhold, N.; Tea, Maria; Huber, Johannes; Hermann, Michael

doi:10.1089/thy.2010.0191

Cited by 161 publications

(117 citation statements)

References 26 publications

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“…This finding means that hypothyroidism or hyperthyroidism, only were a contributing factor to the development and the presence of associated symptoms of disease. Our data are in concordance with study of Ott et al (10). They found that increased anti-TPO levels were associated with a lower quality of life and various general symptoms as chronic fatigue, dry hair, chronic irritability, chronic nervousness in Hashimoto's thyroiditis patients.…”

Section: Table 1 Stratification Of the Dimensions Of Eq-5dsupporting

confidence: 93%

Assessment of health related quality of life in patients with thyroid diseases

Petrov¹

2015

TJS

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We analyzed data from the EQ-5D questionnaire to assess health related quality of life in patients with thyroid diseases. Response data on 26 patients (16 patients with nodular goiter, 10 patients with autoimmune thyroid diseases) and 11 healthy controls are summarized. Results: We found a moderate statistical dependence between the three investigated groups and the presence of pain (χ 2 = 7.739; p = 0.045; Cramer's V = 0.337). We found a statistically significant difference between the three groups (patients with nodular formations, patients with thyroid autoimmune diseases and controls) and the index of health status. There was a statistically significant lower mean index of health status in patients with autoimmune thyroid diseases (58) compared to healthy controls (80). In conclusion, evaluation the quality of life in patients with thyroid disorders by the use of the questionnaire EQ-5D for showed the presence of differences in both in patients with nodular goiter and in those with autoimmune thyroid diseases compared to controls. It is necessary to introduce in clinical practice specific and more detailed questionnaires to assess quality of life in patients with thyroid diseases and the effect of ongoing treatment.

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Section: Table 1 Stratification Of the Dimensions Of Eq-5dsupporting

confidence: 93%

Assessment of health related quality of life in patients with thyroid diseases

Petrov¹

2015

TJS

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“…A previous study that specifically analyzed the correlation between chronic asthenia and thyroidectomy found patients who had undergone TT frequently complained of tiredness or asthenia in performing physical tasks and mental work [12]. It is well known that hypothyroidism, hyperthyroidism, and Hashimoto's thyroiditis may be associated with chronic asthenia [39,42]. However, thyroid surgery itself does not improve QoL except for specific symptoms such as compression.…”

Section: Discussionmentioning

confidence: 99%

The prevalence of post-thyroidectomy chronic asthenia: a prospective cohort study

Scerrino¹,

Raspanti²,

Attard³

et al. 2017

Langenbecks Arch Surg

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Purpose Chronic asthenia (CA) is complained by some patients that have undergone thyroid surgery. We evaluate its impact in patients undergoing unilateral or bilateral thyroidectomy, the trend during a 1-year follow-up, and the possible risk factors. Methods A prospective, cohort study was carried out on 263 patients scheduled for thyroidectomy from 2012 and 2014. Exclusion criteria were as follows: Graves' disease, malignancies requiring radioiodine therapy, post-surgical hypoparathyroidism, laryngeal nerve palsy, abnormal pre-and postoperative thyroid hormone levels, and BMI outside the normal range. Demographics; smoking and alcoholism addiction; cardiac, pulmonary, renal, and hepatic failure; diabetes; anxiety; and depression were recorded. The Brief Fatigue Inventory (BFI) was used to evaluate CA and its possible association with these comorbidities 6 and 12 months after thyroidectomy. Results One hundred seventy-seven patients underwent total thyroidectomy (TT), 54 hemithyroidectomy (HT). Thirty-two patients were not recorded because of the onset of exclusion criteria. In the 6 months after thyroidectomy, in the TT group, 64 patients (36.16%) reported an impairment in the BFI score and only 1 in the TL group. The mean BFI score changed from 1.663(±1.191) to 2.16 (±11.148) in the TT group, from 1.584 (±1.371) to 1.171 (±1.093) in the TL group (p < 0.001). No further significant variations in BFI were reported 1 year after surgery. Conclusions CA worsened after TT, but not after HT. Apart from operative procedure itself, no other risk factor was found be significantly associated with post-thyroidectomy asthenia. Further investigation is needed to determine the causes of CA.

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“…Nowadays, the impairment of thyroid dysfunction or thyroid eye disease on QoL is well established [2][3][4][5][6][7]. However, the negative influence of other thyroid disorders such as benign goitre or chronic autoimmune thyroiditis on patients' QoL has been suggested in recent studies [8][9][10][11].…”

Section: Quality Of Life In Patients With Benign Thyroid Disordersmentioning

confidence: 99%

ThyPROpl — polska wersja kwestionariusza oceny jakości życia u pacjentów z chorobami tarczycy

Sawicka‐Gutaj

Watt

Sowiński

et al. 2015

Endokrynologia Polska

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Introduction: Thyroid disorders have a significant impact on patients' quality of life. ThyPRO is a thyroid-specific quality of life (QoL) questionnaire applicable to patients with benign thyroid disorders. There is substantial evidence for its clinical validity and reliability in patients with benign thyroid disorders. Our aim was to develop a validated Polish version of this questionnaire (ThyPROpl). Material and methods: ThyPROpl was translated and validated according to standard methodology for translation of patient-reported outcomes (PRO). Firstly, two independent translations from English to Polish were performed by two translators native in Polish, and a consensus version was reached in collaboration with an in-country consultant. A third translator prepared a back-translation from Polish to English, which likewise was reviewed by the in-country consultant. The backwards translation was reviewed by a PRO translation expert native in English (Health Research Associates HRA) and by the developer of ThyPRO, who provided additional revisions. Finally, ThyPROpl was tested among five patients with thyroid disorders with cognitive interview techniques, and new changes and clarifications needed for its full understanding were made.

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Hashimoto's Thyroiditis Affects Symptom Load and Quality of Life Unrelated to Hypothyroidism: A Prospective Case–Control Study in Women Undergoing Thyroidectomy for Benign Goiter

Abstract: Women with HT suffer from a high symptom load. Hypothyroidism is only a contributing factor to the development of associated conditions.

Cited by 161 publications

References 26 publications

Assessment of health related quality of life in patients with thyroid diseases

Assessment of health related quality of life in patients with thyroid diseases

The prevalence of post-thyroidectomy chronic asthenia: a prospective cohort study

ThyPROpl — polska wersja kwestionariusza oceny jakości życia u pacjentów z chorobami tarczycy

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