Hashimoto's Thyroiditis Is Associated with HLA-DRw3

Moens, Hilda; Farid, Nadir R.; Sampson, Laura; Noel, Elke P.; Barnard, John M.

doi:10.1056/nejm197807202990306

Cited by 132 publications

(54 citation statements)

References 13 publications

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“…Some evidence for a role of DRB1*04 and DR4 in HT has been previously reported in two smaller HT studies, including Japanese 17 and Italian cohorts, 19 respectively. Studies have also detected strong association of DRB1*03 and DR3 with HT, 8,13,18 whereas we have only detected a borderline association (P ¼ 0.050). These discrepancies between previous studies could be due to ethnic differences or the small data set size used (o400 cases and control subjects).…”

Section: Discussioncontrasting

confidence: 83%

“…6,7 Many small studies have investigated association of the HLA class II region with HT (Table 1). Several associations including DRB1*03, DRB1*04 and the DR3 and DRB1*04-DQB1*03-DQA1*03 (DR4) haplotypes have been proposed 8,13,18,20 however, due to a lack of replication between studies, progress in determining HLA class II associations in HT has been much slower, leaving confusion over whether GD and HT share the same susceptibility loci within this region.…”

Section: Introductionmentioning

confidence: 99%

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Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves’ disease

et al. 2008

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Graves' disease (GD) and Hashimoto's thyroiditis (HT) represent the commonest forms of autoimmune thyroid disease (AITD) each presenting with distinct clinical features. Progress has been made in determining association of HLA class II DRB1, DQB1 and DQA1 loci with GD demonstrating a predisposing effect for DR3 (DRB1*03-DQB1*02-DQA1*05) and a protective effect for DR7 (DRB1*07-DQB1*02-DQA1*02). Small data sets have hindered progress in determining HLA class II associations with HT. The aim of this study was to investigate DRB1-DQB1-DQA1 in the largest UK Caucasian HT case control cohort to date comprising 640 HT patients and 621 controls. A strong association between HT and DR4 (DRB1*04-DQB1*03-DQA1*03) was detected (P ¼ 6.79 Â 10 À7 , OR ¼ 1.98 (95% CI ¼ 1.51-2.59)); however, only borderline association of DR3 was found (P ¼ 0.050). Protective effects were also detected for DR13 (DRB1*13-DQB1*06-DQA1*01) (P ¼ 0.001, OR ¼ 0.61 (95% CI ¼ 0.45-0.83)) and DR7 (P ¼ 0.013, OR ¼ 0.70 (95% CI ¼ 0.53-0.93)). Analysis of our unique cohort of subjects with well characterized AITD has demonstrated clear differences in association within the HLA class II region between HT and GD. Although HT and GD share a number of common genetic markers this study supports the suggestion that differences in HLA class II genotype may, in part, contribute to the different immunopathological processes and clinical presentation of these related diseases.

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Section: Discussioncontrasting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves’ disease

et al. 2008

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“…Because the HLA region is highly polymorphic and contains many immune response genes, it was the first candidate for a genetic region to be studied for association with HT [35]. Earlier studies showed an association of goitrous HT with HLA-DR5 and of atrophic HT with HLA-DR3 [36,37]. Later studies have reported association of HT with HLA-DR3, HLA-DR4, or HLA-DR5 in Caucasian patients [38][39][40][41][42].…”

Section: Etiology and Genetics Of Htmentioning

confidence: 99%

IgG4-related disease of the thyroid glands [Review]

Kakudo

Taniguchi

et al. 2012

Endocr J

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Abstract. Recent reports on Hashimoto's thyroiditis (HT) with increased numbers of IgG4-positive plasma cells suggest that this type of HT may have a close relationship to IgG4-related disease (IgG4-RD). This unique subgroup of HT is termed as IgG4 thyroiditis and reveals distinct clinical, serological, and sonographic features from the non-IgG4 thyroiditis group. On the basis of immunostaining for IgG4, HT was divided into an IgG4 thyroiditis group and a non-IgG4 thyroiditis group. Clinically, IgG4 thyroiditis was associated with younger age group, lower female-male ratio, higher levels of thyroid autoantibodies, diffuse low echogenicity, more rapid progress requiring surgical treatment and more subclinical hypothyroidism. Serum IgG4 concentrations elevated in IgG4 thyroiditis and decreased significantly after a thyroidectomy. Histopathologically, IgG4 thyroiditis showed a higher grade of stromal fibrosis, lymphoplasmacytic infiltration, and follicular cell degeneration than non-IgG4 thyroiditis. IgG4 thyroiditis may represent IgG4-RD of thyroid gland, because it shares common histopathological characteristics with IgG4-RD in other organs. The identification of IgG4-RD of the thyroid gland opens new insights not only for patient's treatment with HT but also for the development of new therapeutic approaches for this rapidly progressive destructive subtype of HT. This article mainly focuses on reviewing the unique histopathological, clinical, and serological features of IgG4 thyroiditis group of HT. The etiology and genetic changes of HT are also discussed.

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“…Despite the obvious differences in the affected organ, patients with Sjogren's syndrome and those with autoimmune thyroid diseases such as Hashimoto's thyroiditis share several histologic ( I), serologic (2,3), and genetic (4,5) features. In fact, some individuals develop the full clinical expression of both disorders (I).…”

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confidence: 99%