Hashimoto thyroiditis is an independent cardiovascular risk factor in clinically hypothyroid patients

Atta, Mohammed N.; Elessawy, Rawhia; Deghedy, Akram; Hafez, Alaa El-Din Sayed; Elsherbiny, Tamer Mohamed

doi:10.1016/j.ajme.2011.09.004

Cited by 9 publications

(8 citation statements)

References 66 publications

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“…Some other studies, in which serum NO level was evaluated in hypoand hyperthyroid individuals, have shown controversial results. Verma et al (35) showed higher serum NO levels in 50 hypothyroid individuals in India, which was similar to Atta et al (18) and Coria et al studies (17) conducted on 60 and 20 hypothyroid cases, respectively. In contrast, other studies showed lower serum NO level (5) or no nitrate changes in hypothyroid patients (15).…”

Section: Discussionsupporting

confidence: 67%

“…diet and drinking water nitrate level rather than serum NOx concentration (12)(13)(14). In limited low sample size human studies, serum NOx concentration measurement in subjects with thyroid dysfunction reveals controversial results (5,(15)(16)(17)(18)(19). As far as we know, however, few studies indicate the correlation between serum NOx and changes in THs in an epidemiologic setting.…”

Section: Introductionmentioning

confidence: 99%

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Association Between Serum Nitric Oxide Level and Changes in Thyroid Function Test in a Population-based Study: Tehran Thyroid Study Participants (TTS)

Ghazisaeidi

Sarvghadi

Ghasemi

et al. 2021

Int J Endocrinol Metab

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Background: Nitric oxide (NO) plays a key role in thyroid function regulation through the inhibition of iodide (I) uptake at the thyroidal sodium-iodide symporter (NIS) and impacts the thyroid vascularity and blood flow. Objectives: This study aimed to evaluate the association between serum NO metabolites (NOx) and thyroid-stimulating hormone (TSH), free thyroxin (FT4), and anti-thyroid peroxidase (TPOAb) changes. Also, it aimed at evaluating the correlation between serum NOx and the incidence of clinical hypothyroidism, characterized by elevated TSH level and decreased FT4 concentration, and subclinical hypothyroidism, characterized by mildly elevated TSH level despite FT4 concentration within the normal range, over three years of follow-up. Methods: This study included 1,137 participants of the Tehran Thyroid study (TTS), aged > 20 years old, for whom data on serum TSH, FT4, and TPOAb in the third and fourth phases, and serum NOx in the third phase were available. Changes in TSH (ΔTSH), FT4 (ΔFT4), and TPOAb (ΔTPO) between the third and fourth phases were calculated, and the associations between serum NOx and ΔTSH, ΔFT4, and ΔTPOAb were assessed after multivariable adjustment using linear regression analysis. Results: No significant association was found between serum NOx and ΔTSH, ΔFT4, and ΔTPOAb after the multivariable adjustment; neither was any observed in TPOAb split groups after multivariable adjustment. No significant association was found between serum NOx tertiles and clinical and subclinical hypothyroidism incidence in the fourth phase of TTS. Conclusions: There was no association between serum NOx levels and changes in TSH, FT4, and TPOAb and clinical and subclinical hypothyroidism incidence.

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Section: Discussionsupporting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Association Between Serum Nitric Oxide Level and Changes in Thyroid Function Test in a Population-based Study: Tehran Thyroid Study Participants (TTS)

Ghazisaeidi

Sarvghadi

Ghasemi

et al. 2021

Int J Endocrinol Metab

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“…The former also had significantly increased CIMT, a biomarker of subclinical atherosclerosis, regardless of thyroid function compared with controls [ 53 ]. Other studies confirmed higher CIMT levels in HT patients than in healthy controls and found that HT is an independent cardiovascular risk factor [ 54 , 55 ]. Topaloglu et al also showed a positive correlation between TPOAb, TgAb levels and TC, LDL cholesterol and negative with HDL cholesterol.…”

Section: Overweight or Obesity And Their Association With Metabolic R...mentioning

confidence: 72%

Metabolic Characteristics of Hashimoto’s Thyroiditis Patients and the Role of Microelements and Diet in the Disease Management—An Overview

Mikulska

Karaźniewicz−Łada

Filipowicz

et al. 2022

IJMS

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Hashimoto’s thyroiditis (HT) is the most common autoimmune disease and the leading cause of hypothyroidism, in which damage to the thyroid gland occurs due to the infiltration of lymphocytes. It is characterized by increased levels of antibodies against thyroid peroxidase and thyroglobulin. In this review, we present the metabolic profile, the effectiveness of micronutrient supplementation and the impact of dietary management in patients with HT. For this current literature review, the databases PubMed, Cochrane, Medline and Embase were reviewed from the last ten years until March 2022. This article provides a comprehensive overview of recent randomized controlled trials, meta-analyses, and clinical trials. Many patients with HT, even in the euthyroid state, have excess body weight, metabolic disorders, and reduced quality of life. Due to frequent concomitant nutritional deficiencies, the role of vitamin D, iodine, selenium, magnesium, iron and vitamin B12 is currently debated. Several studies have underlined the benefits of vitamin D and selenium supplementation. There is still no specific diet recommended for patients with HT, but a protective effect of an anti-inflammatory diet rich in vitamins and minerals and low in animal foods has been suggested. There is insufficient evidence to support a gluten-free diet for all HT patients. Pharmacotherapy, along with appropriate nutrition and supplementation, are important elements of medical care for patients with HT. The abovementioned factors may decrease autoantibody levels, improve thyroid function, slow down the inflammatory process, maintain proper body weight, relieve symptoms, and prevent nutritional deficiencies and the development of metabolic disorders in patients with HT.

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“…revealed that NO levels were signi cantly reduced in hypothyroidism patients (43). Mohammed et al and Kumari et al also reported a signi cant association between NO and thyroid disorders (44,45). On the other hand, of Ghazi Saidi et al's study, they evaluated the correlation between serum nitric oxide concentration and thyroid hormones, and the amount of serum NOx was 30/71 ± 22/17 µmol/liter.…”

Section: Discussion and Resultsmentioning

confidence: 96%

Evaluation of the relationship between serum nitric oxide of patients with thyroid disorders and metabolic syndrome indices and nitrate concentration of consuming water in Shiraz: A case-control study

Jafari

Dehghani

Ghaem

et al. 2022

Preprint

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This case-control study aimed to assess the effect of drinking water nitrate on the serum nitric oxide concentration and the risk of metabolic syndrome (MetS) in the population in the Middle East. The study included 50 control and 50 thyroid disorder cases who referred to two medical centers in 2021. In this study, serum nitric oxide concentration, drinking water nitrate, and metabolic syndrome components were measured in the two groups. The results showed there was a statistically significant difference between serum NO in the case and control groups (p-value < 0.001). There was a positive correlation between the concentration of nitrate in drinking water and serum nitric oxide in the case and control groups; however, this relationship was not significant statistically. A statistically significant difference was found between serum nitric oxide and systolic blood pressure in the cases (p-value < 0/05), but there was no significant difference between MetS and nitric oxide. Therefore, we concluded that the relationship between nitric oxide and nitrate in consuming water should be determined in thyroid patients. In addition to their water consumption, it is better to study the nitrate of foods, especially vegetables.

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Hashimoto thyroiditis is an independent cardiovascular risk factor in clinically hypothyroid patients

Cited by 9 publications

References 66 publications

Association Between Serum Nitric Oxide Level and Changes in Thyroid Function Test in a Population-based Study: Tehran Thyroid Study Participants (TTS)

Association Between Serum Nitric Oxide Level and Changes in Thyroid Function Test in a Population-based Study: Tehran Thyroid Study Participants (TTS)

Metabolic Characteristics of Hashimoto’s Thyroiditis Patients and the Role of Microelements and Diet in the Disease Management—An Overview

Evaluation of the relationship between serum nitric oxide of patients with thyroid disorders and metabolic syndrome indices and nitrate concentration of consuming water in Shiraz: A case-control study

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