Hazards of using hypertonic saline for therapeutic abortion

Johnson, John; Cushner, Irvin M.; Stephens, N. L.

doi:10.1016/0002-9378(66)90467-4

Cited by 19 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Johnson et al (1966) demonstrated in dogs that comparatively small volumes of hypertonic saline injected intravenously can produce rapid death, and for this reason it is imperative to make sure that amniotic fluid can be aspirated at all times during the procedure. If this precaution had been observed in the case of injection into a hydatidiform mole descr'ibed by Frost (1968) the patient might not have died.…”

Section: Discussionmentioning

confidence: 99%

Termination of Pregnancy with Intra-amniotic Hypertonic Saline

Gillmer¹,

Friend²,

Beard³

1971

BMJ

View full text Add to dashboard Cite

SummarySuccessful therapeutic abortion was performed consecutively by an intra-amniotic injection of hypertonic saline in 102 out of 110 patients in whom the size of the uterus corresponded with a pregnancy of' 16 weeks or more.A spontaneous abortion of the fetus followed the injection alone in 92 of the cases, and the overall injection-delivery interval was 39-75 (range 11-98) hours. In 10 women intravenous oxytocin injection was used as an additional uterine stimulant because contractions were not established after 48 hours. Complete spontaneous expulsion of the placenta occurred in 71 cases, and evacuation of the placenta under general anaesthesia was required in the other 31.No major complication occurred among the 110 patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Termination of Pregnancy with Intra-amniotic Hypertonic Saline

Gillmer¹,

Friend²,

Beard³

1971

BMJ

View full text Add to dashboard Cite

show abstract

“…Wagner andassociates (1962, 1966) reported that a 20 per cent saline solution was relatively safe and effective (180,181). However, complications such as endometritis, severe hemorrhage, retained placenta, adnexitis, septic abortion, septicemia, pulmonary embolism and even maternal death have been reported in association of midtrimester abortion by hypertonic saline (2,91,135,20,169,8). There were 35 maternal deaths in 150,OO abortions induced by intra-amniotic instillation of hypertonic saline in the United States during the period from 1972 through 1975.…”

Section: Abortion Techniquesmentioning

confidence: 99%