HBM4EU chromates study – the measurement of hexavalent and trivalent chromium in exhaled breath condensate samples from occupationally exposed workers across Europe

Leese, Elizabeth; Jones, Kate; Bocca, Beatrice; Bousoumah, Radia; Castaño, Argelia; Galea, Karen S.; Iavicoli, Ivo; López, Marta Esteban; Leso, Veruscka; Ndaw, Sophie; Porras, Simo P.; Ruggieri, Flavia; Scheepers, Paul T.J.; Santonen, Tiina; Anzion, Rob; Cattaneo, Andrea; Cavallo, Domenico Maria; Palma, Giuseppe De; Forte, Giovanni; Lehtinen, Risto; Lovreglio, Piero; Melczer, Mathieu; Senofonte, Marta; Spankie, Sally; Dael, Maurice van

doi:10.1016/j.toxlet.2022.12.009

Cited by 10 publications

(2 citation statements)

References 55 publications

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“…The most common route for Cr(VI) occupational exposure is inhalation ( Leese et al., 2023 ). As it is simple, quick, and allows control of the applied dose, intratracheal instillation has been employed in many studies as an alternative exposure procedure.…”

Section: Methodsmentioning

confidence: 99%

Low-dose hexavalent chromium induces mitophagy in rat liver via the AMPK-related PINK1/Parkin signaling pathway

Li,

Zhang

et al. 2024

PeerJ

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Hexavalent chromium (Cr(VI)) is a hazardous metallic compound commonly used in industrial processes. The liver, responsible for metabolism and detoxification, is the main target organ of Cr(VI). Toxicity experiments were performed to investigate the impacts of low-dose exposure to Cr(VI) on rat livers. It was revealed that exposure of 0.05 mg/kg potassium dichromate (K2Cr2O7) and 0.25 mg/kg K2Cr2O7 notably increased malondialdehyde (MDA) levels and the expressions of P-AMPK, P-ULK, PINK1, P-Parkin, and LC3II/LC3I, and significantly reduced SOD activity and P-mTOR and P62 expression levels in liver. Electron microscopy showed that CR(VI) exposure significantly increased mitophagy and the destruction of mitochondrial structure. This study simulates the respiratory exposure mode of CR(VI) workers through intratracheal instillation of CR(VI) in rats. It confirms that autophagy in hepatocytes is induced by low concentrations of CR(VI) and suggest that the liver damage caused by CR(VI) may be associated with the AMPK-related PINK/Parkin signaling pathway.

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Section: Methodsmentioning

confidence: 99%

Low-dose hexavalent chromium induces mitophagy in rat liver via the AMPK-related PINK1/Parkin signaling pathway

Li,

Zhang

et al. 2024

PeerJ

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“…As part of the Human Biomonitoring for Europe (HBM4EU) group initiative, EBC was investigated as a potential matrix for monitoring exposure to Cr VI in a multi-centre study (Finland, France, Italy, UK and the Netherlands). 210 Pre-working week and post-working week EBC samples were collected from 177 workers occupationally exposed to Cr IV , along with control samples ( n = 98) from a non-exposed cohort. Samples were stabilised with 0.5 mmol L −1 EDTA (adjusted to pH 8 using 10% v/v NH 4 OH) immediately after collection and Cr speciation analysis was performed using either LC, μLC or IC with ICP-MS depending on the instrumentation available at the participating laboratories.…”

Section: Applications: Clinical and Biological Materialsmentioning

confidence: 99%

Atomic spectrometry update: review of advances in the analysis of clinical and biological materials, foods and beverages

Patriarca,

Barlow,

Cross

et al. 2024

J. Anal. At. Spectrom.

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Human exposure to chromite mining pollution, the toxicity mechanism and health impact

Khan,

Malik,

Chen

2024

Heliyon

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HBM4EU chromates study – the measurement of hexavalent and trivalent chromium in exhaled breath condensate samples from occupationally exposed workers across Europe

Cited by 10 publications

References 55 publications

Low-dose hexavalent chromium induces mitophagy in rat liver via the AMPK-related PINK1/Parkin signaling pathway

Low-dose hexavalent chromium induces mitophagy in rat liver via the AMPK-related PINK1/Parkin signaling pathway

Atomic spectrometry update: review of advances in the analysis of clinical and biological materials, foods and beverages

Human exposure to chromite mining pollution, the toxicity mechanism and health impact

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