HCH and DDT in Surface Extractable Skin Lipid as a Measure of Human Exposure in India

Dua, V. K.; Pant, Chandra Shekhar; Sharma, V. P.; Pathak, Gita

doi:10.1007/s001289900616

Cited by 13 publications

(2 citation statements)

References 5 publications

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“…Several reports document β-HCH accretion in different tissues including the skin. Due to the correlation between blood and skin quantity of β-HCH residues, monitoring the levels of organochlorine insecticides in the skin has been proposed as a non-invasive method to estimate β-HCH body burden [ 41 ]. Further, a realistic concentration level of β-HCH in different cell types remains completely unexplored.…”

Section: Resultsmentioning

confidence: 99%

Persistent β-Hexachlorocyclohexane Exposure Impacts Cellular Metabolism with a Specific Signature in Normal Human Melanocytes

Papaccio,

Caputo,

Iorio

et al. 2024

Cells

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Background: Cutaneous melanoma arises from skin melanocytes and has a high risk of metastatic spread. Despite better prevention, earlier detection, and the development of innovative therapies, melanoma incidence and mortality increase annually. Major clinical risk factors for melanoma include fair skin, an increased number of nevi, the presence of dysplastic nevi, and a family history of melanoma. However, several external inducers seem to be associated with melanoma susceptibility such as environmental exposure, primarily unprotected sun experience, alcohol consumption, and heavy metals. In recent years, epidemiological studies have highlighted a potential risk of β-hexachlorocyclohexane (β-HCH), the most studied organochlorine pesticide, causing cancer induction including melanoma. Methods: We evaluated in vitro the impact of this pollutant on epidermal and dermal cells, attempting to describe mechanisms that could render cutaneous cells more prone to oncogenic transformation. Results: We demonstrated that β-HCH impacts melanocyte biology with a highly cell-type specific signature that involves perturbation of AKT/mTOR and Wnt/β-catenin signaling, and AMPK activation, resulting in lowering energy reserve, cell proliferation, and pigment production. Conclusions: In conclusion, long-term exposure to persistent organic pollutants damages melanocyte metabolism in its function of melanin production with a consequent reduction of melanogenesis indicating a potential augmented skin cancer risk.

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Section: Resultsmentioning

confidence: 99%

Persistent β-Hexachlorocyclohexane Exposure Impacts Cellular Metabolism with a Specific Signature in Normal Human Melanocytes

Papaccio,

Caputo,

Iorio

et al. 2024

Cells

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“…Due to long residence time of these substances, there is a great interest in examining their presence in the environment. Reports showing their ubiquitous presence have made the situation worse as their residues are found in water (Hassan et al, 1996), ground water (Kaushik et al, 2011;Mudiam et al, 2011), food commodities (Mukherjee and Gopal, 1996), dairy milk (John et al, 2001), bovine milk (Sharma et al, 2007), edible oil (Bajpai et al, 2007), animal feed (Mukherjee and Gopal, 1996), mother's milk (Kumar et al, 2006a), human blood (Waliszewski et al, 2001) and in skin (Dua et al, 1998). Organochlorine pesticides (OCP's) were detected even in the most remote parts of the pristine environment like 52 P. K. Mutiyar et al: Status of organochlorine pesticides ice core from Mt.…”

Section: Introductionmentioning

confidence: 99%

Status of organochlorine pesticides in the drinking water well-field located in the Delhi region of the flood plains of river Yamuna

Mutiyar¹,

Mittal²,

Pekdeger³

2011

Preprint

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This study presents the occurrence of pesticides in a well-field located in Yamuna flood plain of Delhi region. Ground water sampling campaigns were carried out during pre-monsoon and post-monsoon periods covering 21 bore-wells and 5 Ranney wells. Major 17 organochlorine pesticides (OCP's) along with other water quality parameters were monitored during this period. Pesticide concentrations were determined using GC- ECD, while GC-MS was used for confirmatory purposes. OCP's groups like ∑HCH, ∑DDT, endosulfan and aldrin were observed in this well-field. Concentration of OCPs from Ranney wells exceeded the limit (1 μg l<sup>−1</sup>) prescribed by the Bureau of Indian Standards (BIS) in pre-monsoon season, though OCP levels in bore wells were within BIS limits. However, these levels were very close to the World Health Organisation (WHO) and European Union (EU) limit of for pesticides (0.5 μg l<sup>−1</sup>) in many samples. Bore well produced better quality water compared to the water from Ranney wells. Although, the level of OCP's was slightly lower than prescribed limit of national regulatory agency but such low doses may cause long-term damage to human populations if such water is consumed for longer durations. At low doses OCP's acts as endocrine disrupting agent and cause metabolic disorders in local population

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Determination of Organochlorine Pesticides Residues in Human Adipose Tissue, Data from Cukurova, Turkey

Dağlioğlu

Gülmen

Akçan

et al. 2010

Bull Environ Contam Toxicol

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We determined and compared the levels of BHC and DDT isomers and metabolites and HCB in the adipose tissue of 82 cases of autopsies performed at the Morgue Department of Adana Branch of the Council of Forensic Medicine. The relationships between the age, gender, and body mass indexes of cases, and the accumulation of OCs residues were also investigated. Detectable concentrations of p,p'-DDE were found in 100% of adipose tissue samples. Concentrations of OCs in female adipose tissues were significantly higher than male adipose tissues (p < 0.05). The presented work is highly significant, being the first study pointing out the chronic exposure to organochlorine pesticides in Cukurova region.

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HCH and DDT in Surface Extractable Skin Lipid as a Measure of Human Exposure in India

Cited by 13 publications

References 5 publications

Persistent β-Hexachlorocyclohexane Exposure Impacts Cellular Metabolism with a Specific Signature in Normal Human Melanocytes

Persistent β-Hexachlorocyclohexane Exposure Impacts Cellular Metabolism with a Specific Signature in Normal Human Melanocytes

Status of organochlorine pesticides in the drinking water well-field located in the Delhi region of the flood plains of river Yamuna

Determination of Organochlorine Pesticides Residues in Human Adipose Tissue, Data from Cukurova, Turkey

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