HCN and nicotine

Kodirov, Sodikdjon A.

doi:10.1111/apha.13651

Cited by 5 publications

(2 citation statements)

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“…As mentioned above, based on established pharmacology the HCN does not contribute to HR in T. molitor (Feliciano et al, 2011). Therefore, to use the latter against dogma (Kodirov, 2021), the article was evaluated again. However, the statistically relevant digits in values of 33.3 ± 3.3 versus 61.2 ± 2.9 beats · min −1 after application of 30 μM BHQ (2,5‐tert‐butyl‐4,5 hydroquinone), a competitive inhibitor of the SERCA, prompted to scrutinize the visualized data.…”

Section: Neither Ca2+ Clock Nor Hcn Is a Dominant Pacemakermentioning

confidence: 99%

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Probability that there is a mammalian counterpart of cardiac clock in insects

Kodirov

2022

Arch Insect Biochem Physiol

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Whether or not the hyperpolarization‐activated cyclic nucleotide‐gated nonselective cation channel (HCN or funny current If) is involved in pacemaking − recurrent heartbeat, it is attributed to electrical activities in all excitable cells, including those of invertebrates. In latter group of animals prevailingly the electrical signals and function of heart in terms of chrono‐ and inotropy are elucidated. Although in simpler models including insects experimental outcomes are reproducible and robust, involvement of “cardiac clock” mechanism in pacemaking is not conclusive. In this assay, the mechanisms of heartbeat are synthesized by focused comparisons between insect and mammalian hearts.

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Section: Neither Ca2+ Clock Nor Hcn Is a Dominant Pacemakermentioning

confidence: 99%

Section: Neither Ca 2 + Clock Nor Hcn Is a Dominant Pacemakermentioning

confidence: 99%