HCV RNA Genomic sequences and HCV‐E2 glycoprotein in sural nerve biopsies from HCV‐infected patients with peripheral neuropathy

Abstract

These results indicate that nerve vascular HCV RNA/E2 deposits associated to perivascular inflammatory infiltrates were similar in chronically HCV-infected patients, regardless of cryoglobulin occurrence. Given the failure to demonstrate HCV productive infection in the examined sural nerve biopsies, nerve damage is likely to result from virus-triggered immune-mediated mechanisms.

Peripheral neuropathy after viral eradication with direct‐acting antivirals in chronic HCV hepatitis: A prospective study

“…HCV‐related neuropathies include symmetrical axonal sensorimotor neuropathy, accounting for over 50% of cases, distal symmetric painful small‐fibre neuropathy with predominantly sensory features, mononeuritis multiplex, pure motor polyneuropathy or, rarely, demyelinating and autonomic neuropathies. 12 , 43 , 44 Severe peripheral neuropathy, although uncommon, is also described. 8 , 18 , 43 Our study confirms the high prevalence of axonal neuropathy both in CG+and CG‐ HCV‐positive patients, strengthen by the dimension of the cohort examined compared to previous studies.…”

“…Furthermore, recent studies indicate that viral eradication with DAAs is associated with a significant improvement in endothelial function, vascular distensibility, reduction in insulin resistance and improved glycaemic control 15‐17,48,49 . Improved metabolic and vascular functions could thus involve nerve microvasculature, preventing ischaemic damage, curbing endothelial activation and the local inflammatory response 43 …”

Neurologische Komplikationen der Hepatitis-C-Infektion

“…Unabhängig vom Auftreten von Kryo-globuIinen finden sich in Suralisbiopsien HCV-positiver Patienten mit PNP gehäuft perivaskuläre inflammatorische Infiltrate mit mononukleären Zellen [19], was die Immunpathogenese der Neuropathien unterstreicht. Neben der Präsenz von Kryoglobulinen vom Typ II und III (gemischte Kryoglobulinämie) ist insbesondere die Erkrankungsdauer ein Risikofaktor für das Auftreten von PNP bei diesen Patienten [10,20].…”

Neuropatias periféricas e alterações neuropsiquiátricas em pacientes portadores do vírus da Hepatite C: estudo observacional, caso-controle, retrospectivo e prospectivo

“…O RNA-HCV foi isolado em homogeneizados de biópsia de nervo de pacientes por PCR in situ (Authier et al, 2003;Russi et al, 2018), o que pode sugerir papel direto do HCV na patogênese da NP.…”

“…A vasculite frequentemente afeta as artérias que nutrem o epineuro, enquanto o envolvimento de vasos endoneurais é menos frequente (Nemni et al, 1988;Bonetti et al, 1997;Russi et al, 2018). Os infiltrados vasculíticos da vasa nervorum são principalmente linfocíticos (Nemni et al, 1988), enquanto que os infiltrados em torno de vasos que nutrem o endoneuro contêm linfócitos T e macrófagos, e os que ocorrem ao redor dos vasos do epineuro consistem em monócitos, linfócitos T e B (Bonetti et al, 1997).…”