HCV Seroconversion in two Egyptian Hemodialysis Units: Role of Detection Method and Patients Isolation

Nasser, M E; Younes, Khaled; Sany, Dawlat; Youssef, Samar Samir; Mahmoud, Mohamed E.; El-Sayed, Bassim Samy

doi:10.3889/oamjms.2014.022

Cited by 4 publications

(4 citation statements)

References 19 publications

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“…This was agreed by Egyptian study compare between centers uses isolation of HCV positive patients and others don't, and found that seroconversion seen only in units not use isolation [17]. Other studied in Egypt in three different governorates found that incidence of HCV seroconversion is significantly lower in the group of patients within units implementing isolation programs of the HCV infected patients [32].…”

Section: Discussionsupporting

confidence: 56%

Hepatitis C Virus Seroconversion Among Hemodialysis Patients and the Role of Hepatitis C Virus Positive Patient's Isolation in Benha, Egypt

Ibrahim¹,

Elawady²

2017

CMR

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Abstract:The prevalence of hepatitis C virus (HCV) infection in hemodialysis units (HD) is higher than among normal population. Seroconversion was included in many previous studies which constitute a great problem against infection control policies. The aim of this study was to evaluate seroconversion rate and the effect of isolation of hepatitis C positive patients as infection control method. This is controlled prospective study that included 90 patients for 2 years. Isolation policy of hepatitis C positive patients was implemented in the second year of the study. The prevalence of HCV was 48.9% among hemodialysis patients. Seroconversion rate decreased from 15.2% in the first year to 5.1%in the second year after application of isolation. The duration of hemodialysis in months, positive history of blood transfusion and the amount of transfused blood were considered significant factors affecting seroconversion. so we concluded that Isolation of hepatitis C positive patients as an infection control policy is mandatory to control HCV seroconversion in Egypt.

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Section: Discussionsupporting

confidence: 56%

Hepatitis C Virus Seroconversion Among Hemodialysis Patients and the Role of Hepatitis C Virus Positive Patient's Isolation in Benha, Egypt

Ibrahim¹,

Elawady²

2017

CMR

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“…Studies show that early diagnosis not only enables appropriate treatment to those who require but also plays a major role in infection control. 13 Pre-Op and Post-Op measures thereby also include Isolation of HCV positive patients in High dependency units to protect them from transmission before and after surgery. 14 It also includes multiple Blood transfusions which is already a common practice in patients on Chronic end stage renal disease.…”

Section: Discussionmentioning

confidence: 99%

Haemodialysis;

Afzal

Ashraf

Raheel

et al. 2017

TPMJ

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Background: Hepatitis C is an important health issue in chronic kidney diseasepatients especially those on regular hemodialysis. The cause of this high prevalence remainsmulti-factorial. Despite of various infection control measures adopted worldwide, hepatitis chigh seroconversion rates among dialysis patients remain a major health concern. Objectives:The objective of this study was to determine the frequency of seroconversion of hepatitis C inpatients on maintenance hemodialysis in our set-up and also to find the various risk factorsattributing to it. Study Design: Retrospective study. Place and duration of study: Hemodialysisunit of LAHORE GENERAL HOSPITAL since August, 2016. Methods: Forty seven patients onroutine hemodialysis who were initially sero negative for hepatitis C at the time of registrationin Lahore general hospital dialysis centre and frequency of seroconversion to positive for antiHCV was calculated using SPSS 20. The various variables were analyzed on basis of p-value(significant <0.05). Results: Out of total 47 patients, 6 patients (12.80%) were found to besero converted to hepatitis C during the dialysis treatment in our centre. History of surgicalprocedure (major/minor) (83.3%, p value:0.006) and presence of hepatitis C in spouse (66.7%,p value :0.0001) were found to be statistically significant risk factors. Conclusion: The currentstudy indicates the high rates of hepatitis C seroconversion in hemodialysis patients and thevarious contributing risk factors for it. Because of the immunodeficiency in these patients,intense education to medical staff as well as patients themselves will be beneficial in controllingthe spread.

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“…Common risk factors associated with HCV transmission are injection drug use as in addicts, organ transplantation such as liver or kidney, blood and blood product transfusion commonly seen in anemia, long term hemodialysis, occupational exposure to viruses seen in health care workers of HCV, infected therapeutic injections and major & minor surgeries with screening for HCV, dental treatment with non-sterilized equipment, shaving at barber shops without changing old blades and having multiple cuts during the shaves, unprotected sexual contact without using barrier method and vertical transmission from mother - ------------------------------------------------------------------------------Received on 15-01-2021 Accepted on 11-06-2021 to child 5 . The phase before the seroconversion after being inoculated with HCV usually last to about 2 months in immunocompetent subjects and may last for 6-12 months in immune compromised subjects 7 . Hepatitis C virus (HCV) remains the leading cause of liver cirrhosis in patients with chronic kidney disease including patients on long-term hemodialysis.…”

Section: Introductionmentioning

confidence: 99%

Rate of HCV Seroconversion And Its Associated Factors In Hemodialysis Patients

Javaid¹,

Khan²,

Akram³

et al. 2021

PJMHS

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Background: CKD is a worldwide public health problem. HCV is the most frequent complication of patients on hemodialysis, it is very important to screen patients for HCV seropositivity, asit may lead to severe liver disease, complications in renal transplant and death. Aim: To find the incidence of HCV seropositivity and identify factors associated with hemodialysis patients at the Dialysis Center. Methodology: A Retrospective Cohort study conducted at Hemodialysis Unit, Sheikh Zayed Hospital, Lahore from January 2015 to December 2015. Secondary data was collected from all the record files of all the patients included in the study available at Sheikh Zayed hospital. Data was also collected by a questionnaire from patient to determine different variables. Data for age, gender, HCV seroconversion, number of transfusions, emergency dialysis at any other hemodialysis center, surgeries, previous history of HCV, dialyzer reuse and dental procedure etc. was collected and patients were divided in two groups according to HCV status at the end of study. Data for seroconversion was studied for relation with given risk factors using Chi-square test and odds ratios with 95% confidence interval. Binary logistic regression was used to see the adjusted odds ratio of various risk factors for seroconversion. P-value ≤0.05 was considered significant. Results: The mean age of the patients was 43.40±16.37 years. The frequency of previous transfusions was 120(48%) The frequency of emergency dialysis outside Shaikh Zayed Hospital was 76(30.4%). The frequency of surgeries was 126(50.4%). The frequency of dental procedures was 102(40.8%). The mean duration of dialysis was 17.6±5.73. The incidence of HCV seroconversion in hemodialysis patients was 124(49.6%). Conclusion: We concluded that the incidence of HCV seroconversion in hemodialysis patients was 8.2% per year and over a period of six years nearly 49.6% who were undergoing dialysis in our dialysis center. Keywords: HCV seroconversion, hemodialysis patients

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HCV Seroconversion in two Egyptian Hemodialysis Units: Role of Detection Method and Patients Isolation

Abstract: Background: Hepatitis C virus (HCV) infection is a significant cause of morbidity and mortality in end stage renal disease (ESRD) patients on hemodialysis (HD). Routine HCV viremia screening is recommended in those patients but it is not applied.

Cited by 4 publications

References 19 publications

Hepatitis C Virus Seroconversion Among Hemodialysis Patients and the Role of Hepatitis C Virus Positive Patient's Isolation in Benha, Egypt

Hepatitis C Virus Seroconversion Among Hemodialysis Patients and the Role of Hepatitis C Virus Positive Patient's Isolation in Benha, Egypt

Haemodialysis;

Rate of HCV Seroconversion And Its Associated Factors In Hemodialysis Patients

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HCV Seroconversion in two Egyptian Hemodialysis Units: Role of Detection Method and Patients Isolation

Abstract: Background: Hepatitis C virus (HCV) infection is a significant cause of morbidity and mortality in end stage renal disease (ESRD) patients on hemodialysis (HD). Routine HCV viremia screening is recommended in those patients but it is not applied.

Cited by 4 publications

References 19 publications

Hepatitis C Virus Seroconversion Among Hemodialysis Patients and the Role of Hepatitis C Virus Positive Patient&apos;s Isolation in Benha, Egypt

Hepatitis C Virus Seroconversion Among Hemodialysis Patients and the Role of Hepatitis C Virus Positive Patient&apos;s Isolation in Benha, Egypt

Haemodialysis;

Rate of HCV Seroconversion And Its Associated Factors In Hemodialysis Patients

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Hepatitis C Virus Seroconversion Among Hemodialysis Patients and the Role of Hepatitis C Virus Positive Patient's Isolation in Benha, Egypt

Hepatitis C Virus Seroconversion Among Hemodialysis Patients and the Role of Hepatitis C Virus Positive Patient's Isolation in Benha, Egypt