HD-tDCS over motor cortex facilitates figurative and literal action sentence processing

Johari, Karim; Riccardi, Nicholas; Malyutina, Svetlana; Modi, Mirage; Desai, Rutvik H.

doi:10.1016/j.neuropsychologia.2021.107955

Cited by 12 publications

(17 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…compared to non-action, aligning with findings from previous brain stimulation studies (Liuzzi et al, 2010;Branscheidt et al, 2018;Gijssels et al, 2018;Johari et al, 2021;Vitale et al, 2021). The majority of significant findings in the present study had a medium effect size, and few findings had small effect size as measured by Cohen's d and partial eta squared (η 2 p ).…”

Section: Figuresupporting

confidence: 92%

“…For statistical analysis, one tailed t-tests were used to examine the following contrasts: (1) action vs. non-action verbs; (2) manipulable vs. non-manipulable nouns; with net accuracy, net RT, and net priming as dependent variables. As discussed in Johari et al ( 2021 ) and Fernandino et al (2013) the interactions in repeated measure ANOVA are equivalent to computing a “net RT” (cathodal RT-sham RT) for each condition, and comparing conditions with a t-test, with the difference that directional testing is possible for t-tests, while it is not for ANOVAs (Howell, 2012 ; Fernandino et al, 2013b ). Since our analyses were hypothesis-driven with planned comparisons, we did not apply corrections for multiple comparisons.…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, the application of tDCS over left M1 facilitated lexical retrieval of action verbs relative to object words in post-stroke aphasia (Branscheidt et al, 2018 ). In a recent study, we demonstrated that high definition tDCS of hand motor area (HMA) enhanced the processing of sentences with literal and figurative action verbs compared to sentences with visual verbs (Johari et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

HD-tDCS of primary and higher-order motor cortex affects action word processing

Johari

Riccardi

Malyutina³

et al. 2022

Front. Hum. Neurosci.

Self Cite

View full text Add to dashboard Cite

The contribution of action-perception systems of the brain to lexical semantics remains controversial. Here, we used high-definition transcranial direct current stimulation (HD-tDCS) in healthy adults to examine the role of primary (left hand motor area; HMA) and higher-order (left anterior inferior parietal lobe; aIPL) action areas in action-related word processing (action verbs and manipulable nouns) compared to non-action-related control words (non-action verbs and non-manipulable nouns). We investigated stimulation-related effects at three levels of semantic processing: subliminal, implicit, and explicit. Broadly, we found that stimulation of HMA and aIPL resulted in relative facilitation of action-related language processing compared to non-action. HMA stimulation facilitated action verb processing in subliminal and implicit task contexts, suggesting that HMA helps represent action verbs even in semantically shallow tasks. HMA stimulation also facilitated manipulable noun comprehension in an explicit semantic task, suggesting that HMA contributes to manipulable noun comprehension when semantic demands are high. aIPL stimulation facilitated both manipulable noun and action verb processing during an implicit task. We suggest that both HMA and aIPL play a functional role in action semantics. HMA plays a general role in the semantics of actions and manipulable objects, while aIPL is important only when visuo-motor coordination is required for the action.

show abstract

Section: Figuresupporting

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

HD-tDCS of primary and higher-order motor cortex affects action word processing

Johari

Riccardi

Malyutina³

et al. 2022

Front. Hum. Neurosci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…In the current group of patients, t tests revealed that response times (RT) and accuracies (ACC) did not significantly differ (RT p = 0.35; ACC p = 0.24) between the literal (M RT = 4,802 ms, SD RT = 963 ms; M ACC = 77.7%, SD ACC = 15.3%) and figurative conditions (M RT = 4,638 ms, SD = 954 ms; M ACC = 80.9%, SD ACC = 14.5%), so the two conditions were combined. There is evidence that, in sentences, high action-relatedness and figurative language may involve distributed brain areas in addition to classic language regions (e.g., Johari et al, 2021), but core language-related regions (the focus of the current study) are still expected to be involved in the majority of language processing (Binder & Desai, 2011;Binder et al, 2009), especially after collapsing all sentence types together.…”

Section: Auditory Sentence Sensibilitymentioning

confidence: 81%

Canonical Sentence Processing and the Inferior Frontal Cortex: Is There a Connection?

Riccardi

Rorden

Fridriksson

et al. 2022

Neurobiology of Language

Self Cite

View full text Add to dashboard Cite

The role of left inferior frontal cortex (LIFC) in canonical sentence comprehension is controversial. Many studies have found involvement of LIFC in sentence production or complex sentence comprehension, but negative or mixed results are often found in comprehension of simple or canonical sentences. We used voxel-, region-, and connectivity-based lesion symptom mapping (VLSM, RLSM, CLSM) in left-hemisphere chronic stroke survivors to investigate canonical sentence comprehension while controlling for lexical-semantic, executive, and phonological processes. We investigated how damage and disrupted white matter connectivity of LIFC and two other language-related regions, the left anterior temporal lobe (LATL) and posterior temporal-inferior parietal area (LpT-iP), affected sentence comprehension. VLSM and RLSM revealed that LIFC damage was not associated with canonical sentence comprehension measured by a sensibility judgment task. LIFC damage was associated instead with impairments in a lexical semantic similarity judgment task with high semantic/executive demands. Damage to the LpT-iP, specifically posterior middle temporal gyrus (pMTG), predicted worse sentence comprehension after controlling for visual lexical access, semantic knowledge, and auditory-verbal short-term memory (STM), but not auditory single-word comprehension, suggesting pMTG is vital for auditory language comprehension. CLSM revealed that disruption of left-lateralized white-matter connections from LIFC to LATL and LpT-iP was associated with worse sentence comprehension, controlling for performance in tasks related to lexical access, auditory word comprehension, and auditory-verbal STM. However, the LIFC connections were accounted for by the lexical semantic similarity judgment task, which had high semantic/executive demands. This suggests that LIFC connectivity is relevant to canonical sentence comprehension when task-related semantic/executive demands are high.

show abstract

“…It is a concern, however, that whether our model represents the group of participants well. While it is optimal to obtain simulation results from each individual, using a sample head model in a multi-channel stimulation experiment is not uncommon [53][54][55] . The individual whose MRI was used in the simulation of the current study was young (with same range of age as the participants) and healthy male with the same nationality as the participants.…”

Section: Discussionmentioning

confidence: 99%

80 Hz but not 40 Hz, transcranial alternating current stimulation of 80 Hz over right intraparietal sulcus increases visuospatial working memory capacity

Park

Lee

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Working memory (WM) is a complex cognitive function involved in the temporary storage and manipulation of information, which has been one of the target cognitive functions to be restored in neurorehabilitation. WM capacity is known to be proportional to the number of gamma cycles nested in a single theta cycle. Therefore, gamma-band transcranial alternating current stimulation (tACS) should be dependent of the stimulation frequency; however, the results of previous studies that employed 40 Hz tACS have not been consistent. The optimal locations and injection currents of multiple scalp electrodes were determined based on numerical simulations of electric field. Experiments were conducted with 20 healthy participants. The order of three stimulation conditions (40 Hz tACS, 80 Hz tACS, and sham stimulation) were randomized but counterbalanced. Visual hemifield-specific visual WM capacity was assessed using a delayed visual match to the sample task. High gamma tACS significantly increased WM capacity, while low gamma tACS had no significant effect. Notably, 80 Hz tACS increased WM capacity on both the left and right visual hemifields, while previous tACS studies only reported the effects of tACS on contralateral hemifields. This is the first study to investigate the frequency-dependent effect of gamma-band tACS on WM capacity. Our findings also suggest that high gamma tACS might influence not only WM capacity but also communication between interhemispheric cortical regions. It is expected that high gamma tACS could be a promising neurorehabilitation method to enhance higher-order cognitive functions with similar mechanisms.

show abstract

HD-tDCS over motor cortex facilitates figurative and literal action sentence processing

Cited by 12 publications

References 64 publications

HD-tDCS of primary and higher-order motor cortex affects action word processing

HD-tDCS of primary and higher-order motor cortex affects action word processing

Canonical Sentence Processing and the Inferior Frontal Cortex: Is There a Connection?

80 Hz but not 40 Hz, transcranial alternating current stimulation of 80 Hz over right intraparietal sulcus increases visuospatial working memory capacity

Contact Info

Product

Resources

About