HDAC1 and HDAC2 Control the Specification of Neural Crest Cells into Peripheral Glia

Jacob, Claire; Lötscher, Pirmin; Engler, Stefanie; Baggiolini, Arianna; Tavares, Sandra Varum; Brügger, Valérie; John, Nessy; Büchmann-Møller, Stine; Snider, Paige; Conway, Simon J.; Yamaguchi, Teppei; Matthias, Patrick; Sommer, Lukas; Mantei, Ned; Suter, Ueli

doi:10.1523/jneurosci.5212-13.2014

Cited by 82 publications

(102 citation statements)

References 40 publications

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“…HDACs are also expressed in the migratory neural crest (Simoes-Costa et al, 2014) and are involved in the diversification of derivatives. For example, HDACs act in the repression of foxd3 during melanophore specification in zebrafish (Ignatius et al, 2008) and have been shown to play important roles in the development of peripheral glia (Jacob et al, 2014) and ectomesenchymal derivatives (Haberland et al, 2009a) in the mouse.…”

Section: Epigenetic Regulation In Neural Crest Formationmentioning

confidence: 99%

Establishing neural crest identity: a gene regulatory recipe

2015

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The neural crest is a stem/progenitor cell population that contributes to a wide variety of derivatives, including sensory and autonomic ganglia, cartilage and bone of the face and pigment cells of the skin. Unique to vertebrate embryos, it has served as an excellent model system for the study of cell behavior and identity owing to its multipotency, motility and ability to form a broad array of cell types. Neural crest development is thought to be controlled by a suite of transcriptional and epigenetic inputs arranged hierarchically in a gene regulatory network. Here, we examine neural crest development from a gene regulatory perspective and discuss how the underlying genetic circuitry results in the features that define this unique cell population.

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Section: Epigenetic Regulation In Neural Crest Formationmentioning

confidence: 99%

Establishing neural crest identity: a gene regulatory recipe

2015

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“…Cloning and expression of PLINs in yeast was performed as previously described (Jacquier et al, 2013). For mammalian expression, we used pLENTI6-mCherry-Plin2 (Eyre et al, 2014) and GFP-PLIN2 and mss-GFP-PLIN2 that were cloned into pSiCoR-GFP-EF1α (Jacob et al, 2014). All constructs were verified by sequencing.…”

Section: Gfp Tagging and Western Blot Analysismentioning

confidence: 99%

Mature lipid droplets are accessible to ER luminal proteins

Mishra

Khaddaj

Cottier

et al. 2016

Journal of Cell Science

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Lipid droplets are found in most organisms where they serve to store energy in the form of neutral lipids. They are formed at the endoplasmic reticulum (ER) membrane where the neutral-lipidsynthesizing enzymes are located. Recent results indicate that lipid droplets remain functionally connected to the ER membrane in yeast and mammalian cells to allow the exchange of both lipids and integral membrane proteins between the two compartments. The precise nature of the interface between the ER membrane and lipid droplets, however, is still ill-defined. Here, we probe the topology of lipid droplet biogenesis by artificially targeting proteins that have high affinity for lipid droplets to inside the luminal compartment of the ER. Unexpectedly, these proteins still localize to lipid droplets in both yeast and mammalian cells, indicating that lipid droplets are accessible from within the ER lumen. These data are consistent with a model in which lipid droplets form a specialized domain in the ER membrane that is accessible from both the cytosolic and the ER luminal side.

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“…46 For instance, HDAC1/2 activity has been shown to be essential for the differentiation of NCCs into Schwann cells and satellite glia, in part through direct activation of Mpz expression. 47 Furthermore, the ZEB2 transcription factor has been shown to be a critical regulator of Schwann cell maturation through HDAC/NuRD-mediated repression of genes that inhibit maturation such as Hey2, Sox2 and Ednrb. 48,49 When focusing on the regulation of Nr2f1 only, a role for its antisense long non-coding RNA A830082k12Rik is also likely.…”

Section: Nr2f1 Is a Newly Identified Potent Regulator Of Enteric Gliomentioning

confidence: 99%