HDL is the major source of vitamin E for type II pneumocytes

Kolleck, Ingrid; Schlame, Michael; Fechner, Henry; Looman, A. C.; Wissel, Heide; Rüstow, Bernd

doi:10.1016/s0891-5849(99)00139-2

Cited by 105 publications

(79 citation statements)

References 31 publications

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“…The in vivo importance of HDL in providing α-TOH to the central nervous system was highlighted by Goti et al [80] . In agreement with this finding, Kolleck et al [64] found that HDL might be the primary source of vitamin E for type Ⅱ pneumocytes.…”

Section: Vascular Transportsupporting

confidence: 56%

“…The transport of vitamin E in blood circulation follows largely that of cholesterol within lipoprotein metabolism [64] . Lipoproteins serve as carriers for lipophilic molecules, such as cholesterol, triglycerides and vitamin E, to distribute them between the liver and different organs and tissues [43] .…”

Section: Vascular Transportmentioning

confidence: 99%

“…High-density lipoproteins provides the means for α-TOH to be secreted out of the extrahepatic tissues and enter into circulation to be transported back to the liver. High-density lipoprotein particles contain the lowest concentration of vitamin E per particle but HDL is the most potent donor of vitamin E to several target tissues [64,74,80] , despite the larger amounts of LDL in plasma. One possible explanation for this observation was given by Clevidence et al [81] , who speculated that HDL contain more components for binding α-TOH besides serum ApoAI [69] .…”

Section: Vascular Transportmentioning

confidence: 99%

“…Furthermore, it has been suggested that the supply of vitamin E by HDL could be more important under pathophysiological conditions, such as oxidative stress, most likely independent from the HDL-mediated uptake of cholesterol [64] . The HDL-interacting scavenger receptor SR-B1 controls the uptake and accumulation of α-TOH in specific tissues [82] .…”

Section: Vascular Transportmentioning

confidence: 99%

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Complexity of vitamin E metabolism

Schmölz¹,

Birringer²,

Lorkowski³

et al. 2016

WJBC

183

138

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Bioavailability of vitamin E is influenced by several factors, most are highlighted in this review. While gender, age and genetic constitution influence vitamin E bioavailability but cannot be modified, life-style and intake of vitamin E can be. Numerous factors must be taken into account however, i.e. , when vitamin E is orally administrated, the food matrix may contain competing nutrients. The complex metabolic processes comprise intestinal absorption, vascular transport, hepatic sorting by intracellular binding proteins, such as the significant α-tocopherol-transfer protein, and hepatic metabolism. The coordinated changes involved in the hepatic metabolism of vitamin E provide an effective physiological pathway to protect tissues against the excessive accumulation of, in particular, non-α-tocopherol forms. Metabolism of vitamin E begins with one cycle of CYP4F2/CYP3A4-dependent ω-hydroxylation followed by five cycles of subsequent β-oxidation, and forms the water-soluble end-product carboxyethylhydroxychroman. All known hepatic metabolites can be conjugated and are excreted, depending on the length of their sidechain, either via urine or feces. The physiological handling of vitamin E underlies kinetics which vary between the different vitamin E forms. Here, saturation of the side-chain and also substitution of the chromanol ring system are important. Most of the metabolic reactions and processes that are involved with vitamin E are also shared by other fat soluble vitamins. Influencing interactions with other nutrients such as vitamin K or pharmaceuticals are also covered by this review. All these processes modulate the formation of vitamin E metabolites and their concentrations in tissues and body fluids. Differences in metabolism might be responsible for the discrepancies that have been observed in studies performed in vivo and in vitro using vitamin E as a REVIEW

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Section: Vascular Transportsupporting

confidence: 56%

Section: Vascular Transportmentioning

confidence: 99%

Section: Vascular Transportmentioning

confidence: 99%

Section: Vascular Transportmentioning

confidence: 99%

See 2 more Smart Citations

Complexity of vitamin E metabolism

Schmölz¹,

Birringer²,

Lorkowski³

et al. 2016

WJBC

183

138

View full text Add to dashboard Cite

show abstract

“…The plasma phospholipid transfer protein makes the exchange of tocopherol between LDL and HDL possible (10). In lung, liver, and brain (blood-brainbarrier), HDL-associated ®-tocopherol is the primary source of vitamin E and its uptake is regulated by the scavenger receptor SR-BI (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Vitamin E 80th Anniversary: A Double Life, Not Only Fighting Radicals

Ricciarelli¹,

Zingg²,

Azzi³

2001

IUBMB Life

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Vitamin E: Textbooks require updating

Azzi

Zingg

2005

Biochem Molecular Bio Educ

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Vitamin E was discovered in 1922, but in more than 60 years many new findings have added to the early one. However, its description in many textbooks has not been proportionally updated. The result is an inaccurate, incomplete, and often incorrect description of the function of this vitamin. In some other textbooks, vitamin E is absolutely neglected. In almost all books the existence of vitamin E deficiency diseases is ignored. Recent findings on vitamin E molecular functions and its related diseases are described in this article.

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HDL is the major source of vitamin E for type II pneumocytes

Cited by 105 publications

References 31 publications

Complexity of vitamin E metabolism

Complexity of vitamin E metabolism

Vitamin E 80th Anniversary: A Double Life, Not Only Fighting Radicals

Vitamin E: Textbooks require updating

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