he Physiological Effects on Hormones levels and Kidneys Functions Induced by The Anabolic Androgenic Drug (Sustanon) in Male Guinea Pigs

Abstract

Problem statement:In recent years, the intentional abuse of anabolic androgenic drugs by athletes has increased rapidly in many countries to become a serious negative phenomenon. Athletes, specially in power sports, abuse these drugs such as Sustanon in high doses to obtain a rapid and huge increasing in the muscles mass and to improve their performance during the sport competitions. This abuse causes severe adverse effects among the abusers. Approach: The present physiological study was performed to answer the following question: could Sustanon abuse induce marked abnormal alterations in some hormones levels and in the kidneys functions?. The current study was needed due to the lack of sufficient information about the hormonal and nephritic adverse effects caused by Sustanon abuse in particular. This study on male Guinea pigs aimed to investigate the potential abnormal alterations in the levels of some hormones and in the kidney functions induced by repeated administration of two Sustanon doses. The treated animals were injected intramuscularly (i.m.) once a week with Sustanon doses as follow (15 mg to control group according to (t-test). The results have been described and discussed in full details within the text. Conclusion/Recommendations: The current hormonal results proved the occurrence of severe abnormal alterations in the serum levels of the thyroid gland hormones, Cortisol and Insulin under the influence of Sustanon treatment. This indicated that abusing Sustanon for long periods by athletes can cause serious pathological hormonal disorders in the abusers. In addition, the present nephritic results can be considered as strong proof that abusing Sustanon for long periods by athletes can induce severe defects and disorders in the kidney functions. This may lead to cause serious pathological damages in the kidneys structure in the late stages. Due to these serious adverse effects, it is recommended that much more official and medical restrictions should be applied to prevent abusers from obtaining these drugs in order to decrease the continuation of this negative health problem. In addition, the study recommends also that athletes and youths should be provided with much more medical information and enlightenment about the health risks and the complications of abusing these drugs through media.

Histological and physiological effects of Sustanon on the liver and Kidneys of male rats

“…ALT increase is more indicative of liver damage than AST (26) because AST increase is indicative of muscle and hepatocytes damage due to the fact that this enzyme is found in muscles too (10). This result was different from that obtained from other results when serum parameters used f26r monitering hepatic function did not change considerably after the injection with these steroids (4). Another result in this study was that hepatocytes apoptosis similar to what was seen in the use of blodenon, which is another anabolic androgenic steroid,was noticed (15).…”