Head and neck Langerhans cell histiocytosis: two case reports and review of the literature

Intradural Langerhans' Cell Histiocytosis Invading Frontal Bone of Skull: A Case Report with A Brief Review

“…The virus or genetic may be predisposing factors, yet the exact of LCH cause is still unknown [11]. Recent research has discovered a clonal myeloid origin of the LCH cells and identified several activating mutations alongside the MAPK signal transduction pathway [12]. The progress decides the form of LCH, prognosis, course of the disease, single or multiple lesion, and onset.…”

“…The radiographic features are usually quite characteristic. This disease mostly involves the skull, spines, and long bones with typical a hole-in-hole (punched out lytic) appearance because of the different destruction rates of the bone's two tables [3,17,18]. Radiology can indicate the presence of LCH, but the biopsy (histopathology) is essential for the final diagnosis.…”

“…The patients with disseminated disease may present with lymphadenopathy, skin lesions, or diabetes insipidus [2]. Treatment range from excision, chemotherapy, and radiation [3]. We report an unusual and first case of LCH involving frontal bone of the skull, arising from dura matter in a 22 yrs.'…”

“…Of Patients with the multisystem disease (30%), around 50% have equal or more than the one risk organ involved. It can affect bone (80%), lungs (15%), or lymph nodes (5-10%) [3]. Langerhans' cell histiocytosis affects one or many-body systems or tissues.…”