Head and Neck Sarcomas: A Comprehensive Cancer  Center Experience

Tejani, Mohamedtaki Abdulaziz; Galloway, Thomas J.; Lango, Miriam; Ridge, John A.; Mehren, Margaret von

doi:10.3390/cancers5030890

Cited by 57 publications

(36 citation statements)

References 29 publications

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“…Notably, several recent larger series of LGFMS did not identify any cases in the head and neck region [4,5]. Many authors did not specify the location beyond ''head/neck''.…”

Section: Discussionmentioning

confidence: 92%

“…Some of the most frequently encountered sarcomas include rhabdomyosarcoma and Ewing sarcoma in children and young adults, and rhabdomyosarcoma, synovial sarcoma, Kaposi sarcoma, and angiosarcoma in older adults [2,3]. Primary head and neck sarcomas commonly involve the scalp, face, and nasal cavity, while the larynx and upper airway are more unusual sites [1,4,5]. The prognosis is related to the tumor type and extent of resection, which is often incomplete due to anatomic restrictions [5].…”

Section: Introductionmentioning

confidence: 98%

“…Primary head and neck sarcomas commonly involve the scalp, face, and nasal cavity, while the larynx and upper airway are more unusual sites [1,4,5]. The prognosis is related to the tumor type and extent of resection, which is often incomplete due to anatomic restrictions [5].…”

Section: Introductionmentioning

confidence: 99%

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Low-Grade Fibromyxoid Sarcoma of the Head and Neck: A Clinicopathologic Series and Review of the Literature

Cowan

Thompson

Leon

et al. 2015

Head and Neck Pathol

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Low-grade fibromyxoid sarcoma (LGFMS) is a deceptively bland malignancy with potential for late recurrence and metastasis, which usually occurs in the deep soft tissues of the extremities and trunk. Most LGFMSs harbor a characteristic gene fusion of FUS-CREB3L2, and recently MUC4 immunostaining has been found to be highly sensitive and specific for the diagnosis. We present a dedicated series of head and neck LGFMS, including the first reported laryngeal case, as well as a review of reported head and neck cases. The surgical pathology archives of our three institutions were searched for cases of LGFMS arising within the head and neck, and four cases were identified. The H&E slides were reviewed, and immunohistochemistry were performed for pancytokeratin, p63, p40, EMA, S100 protein, β-catenin, actin, CD34, and MUC4. The patients were 6, 43, 45, and 73 years old (mean 41.8 years) and included three males and one female. The tumors were located in the posterior cervical spine, facial skin, mandible, and larynx. The tumors were treated with surgical excision, and all four had histologic features typical for LGFMS including alternating myxoid and fibrous areas with prominent curvilinear vasculature. All tumors were MUC4 positive (100%), 2/4 (50%) were p63 positive, 1/4 (25%) showed focal EMA positivity; all 4 were negative for pancytokeratin, p40, S100 protein, β-catenin, actin, and CD34. LGFMS is a low grade sarcoma that rarely develops in the head and neck. Due to its rarity, a pathologist may not consider LGFMS in the differential diagnosis of spindle cell neoplasms within the head and neck. Immunohistochemical staining is helpful, but stains should be selected carefully to avoid misdiagnosis.

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“…Notably, several recent larger series of LGFMS did not identify any cases in the head and neck region [4,5]. Many authors did not specify the location beyond ''head/neck''.…”

Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Low-Grade Fibromyxoid Sarcoma of the Head and Neck: A Clinicopathologic Series and Review of the Literature

Cowan

Thompson

Leon

et al. 2015

Head and Neck Pathol

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“…Outcomes have historically been worse in this group, due to anatomic constraints leading to difficulty in completely excising tumors, with high rates of local recurrence [8,9].…”

Section: Discussionmentioning

confidence: 99%

Trapezius Flap Reconstruction of Scalp Defect After Removal of Occipital Fibrosarcoma in Neurofibromatosis Type I Patient

Kabulo¹,

Ntenga²,

Nemayire³

et al. 2017

IJNPT

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Neurofibromatosis type 1 (NF1) is an autosomal dominant condition affecting approximately 1 in 3000 live births.The manifestations of this condition are extremely variable, even within families, and genetic counseling is consequently difficult with regard to prognosis. Individuals with NF1 are acknowledged to be at increased risk of malignancy. Several studies have previously attempted to quantify this risk, but have involved relatively small study populations. Soft tissue tumors represent a heterogeneous group of mesenchymal and neural lesions. We report a case of giant scalp Fibrosarcoma of the scalp in patient with neurofibromatosis type I without intracranial extension, in a 35 year old female which was excised completely along with the involved overlying skin, and reconstruction was done to cover the defect using trapezius flap and split thickness skin graft from the right thigh. She is doing well after treatment and is in regular follow up while awaiting further management by the oncologists.

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“…Radiation therapy is followed after resection of all high-grade sarcomas and large tumors, and when margins of resection are closed or microscopically involved. Systemic chemotherapy is recommended for tumors with a significant risk of distant metastases [5]. However, cancer treatment with radiation and chemotherapy methods are also able to trigger other cancers in the body [1].…”

Section: Introductionmentioning

confidence: 99%

Optimization of a Neutron Beam Shaping Assembly Design for BNCT and Its Dosimetry Simulation Based on McNPX

Ardana

Sardjono²

2017

Tri Dasa Mega

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OPTIMIZATION OF A NEUTRON BEAM SHAPING ASSEMBLY DESIGN FOR BNCT AND ITS DOSIMETRY SIMULATION BASED ON MCNPX.This article involves two main objectives of BNCT system. The first goal includes optimization of 30 MeV Cyclotron-based Boron Neutron Capture Therapy (BNCT) beam shaping assembly. The second goal is to calculate the neutron flux and dosimetry system of BNCT in the head and neck soft tissue sarcoma. A series of simulations has been carried out using a Monte Carlo N Particle X program to find out the final composition and configuration of a beam shaping assembly design to moderate the fast neutron flux, which is generated from the thick beryllium target. The final configuration of the beam shaping assembly design includes a 39 cm aluminum moderator, 8.2 cm of lithium fluoride as a fast neutron filter and a 0.5 cm boron carbide as a thermal neutron filter. Bismuth, lead fluoride, and lead were chosen as the aperture, reflector, and gamma shielding, respectively. Epithermal neutron fluxes in the suggested design were 2.83 x 10 9 n/s cm -2 , while other IAEA parameters for BNCT beam shaping assembly design have been satisfied. In the next step, its dosimetry for head and neck soft tissue sarcoma is simulated by varying the concentration of boron compounds in ORNL neck phantom model to obtain the optimal dosimetry results. MCNPX calculation showed that the optimal depth for thermal neutrons was 4.8 cm in tissue phantom with the maximum dose rate found in the GTV on each boron concentration variation. The irradiation time needed for this therapy were less than an hour for each level of boron concentration. Keywords: Optimization, Beam Shaping Assembly, BNCT, Dosimetry, 30 MeV Cyclotron, MCNPX. ABSTRAK

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Head and Neck Sarcomas: A Comprehensive Cancer Center Experience

Cited by 57 publications

References 29 publications

Low-Grade Fibromyxoid Sarcoma of the Head and Neck: A Clinicopathologic Series and Review of the Literature

Low-Grade Fibromyxoid Sarcoma of the Head and Neck: A Clinicopathologic Series and Review of the Literature

Trapezius Flap Reconstruction of Scalp Defect After Removal of Occipital Fibrosarcoma in Neurofibromatosis Type I Patient

Optimization of a Neutron Beam Shaping Assembly Design for BNCT and Its Dosimetry Simulation Based on McNPX

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