Head and neck soft tissue sarcomas: prognostic factors and outcome in a series of patients treated at a single institution

Mattavelli, Davide; Miceli, Rosalba; Radaelli, Stefano; Mattavelli, Franco; Cantù, Giulio; Barisella, Marta; Quattrone, Pasquale; Stacchiotti, Silvia; Sangalli, Claudia; Casali, Paolo G.; Gronchi, Alessandro; Fiore, Marco

doi:10.1093/annonc/mdt126

Cited by 69 publications

(88 citation statements)

References 38 publications

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“…In one of the largest single institution series 21 of 38 (55%) patients with paranasal soft tissue sarcoma received (neo)adjuvant chemotherapy. Unfortunately, data were insufficient to evaluate the role of (neo)adjuvant treatments [74]. Generally, the results of adjuvant chemotherapy in treatment of head and neck soft tissue sarcoma have been disappointing [75].…”

Section: Sarcomamentioning

confidence: 99%

The role of systemic therapy in the management of sinonasal cancer: A critical review

Bossi

Saba

Vermorken

et al. 2015

Cancer Treatment Reviews

101

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Section: Sarcomamentioning

confidence: 99%

The role of systemic therapy in the management of sinonasal cancer: A critical review

Bossi

Saba

Vermorken

et al. 2015

Cancer Treatment Reviews

101

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“…In stage IV the survival is about of 40,0% in young patients and with smaller tumors than 5cm 7,10,15 . In addition, histologic variant of calcifying type of SSs frequently have better survival rate than the type of the case.…”

Section: Discussionmentioning

confidence: 98%

“…SSs are also positive for EMA, vimentin, BCL-2, CD99, and calponin, which facilitates arriving at a correct and conclusive diagnosis of the tumor 10 . The immunohistochemistry techniques performed in this case revealed sections that showed intensely positive staining for vimentin and diffuse staining in epithelial cells, cytoplasmic/membrane staining for EMA, CD99-Synovial sarcoma: case report positive staining in the membrane of rounded cells, and Bcl-2-positive staining involving the membrane and cytoplasm.…”

Section: Discussionmentioning

confidence: 98%

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Synovial sarcoma: case report

Ribeiro

Monteiro

Melo

et al. 2017

RGO, Rev. Gaúch. Odontol.

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RESUMOSarcomas sinoviais são neoplasias raras e agressivas, localizadas na região da cabeça e pescoço e geralmente ocorrem em adultos jovens. Relato do caso: este relato apresenta um caso de sarcoma sinovial em um paciente de 15 anos que procurou tratamento médico para sintomas dolorosos e associados à disfagia. A lesão era nodular, extensa, localizada na região da parótida e estendida à região cervical esquerda. O paciente foi tratado em um hospital de referência com um protocolo de tratamento que inicialmente incluiu quimioterapia por seis meses e cirurgia para tentar excisar a lesão, mas a cirurgia foi ineficaz porque a total remoção do tumor poderia comprometer estruturas vitais importantes. A tomografia computadorizada mostrou uma área hipodensa com crescimento difuso, sem envolvimento dos ossos faciais, e a análise histopatológica revelou células fusiformes pleomórficas e ovais, com células epiteliais arredondadas formando ninhos rodeados por tecido fibroso. A análise imunohistoquímica foi conclusiva para o diagnóstico de um sarcoma sinovial de alto grau na região cervical parotídea esquerda. A equipe médica optou pelo tratamento paliativo com radioterapia cervical. O paciente permaneceu hospitalizado por quatro meses após a cirurgia e faleceu 15 meses após o diagnóstico, devido à obstrução das vias aéreas pelo rápido crescimento tumoral residual. O sarcoma sinovial, quando diagnosticado tardiamente pode reduzir a sobrevida dos pacientes por causa de complicações que o crescimento do tumor pode trazer para o prognóstico e qualidade de vida.Termos de indexação: Quimioterapia de indução. Neoplasias. Sarcoma sinovial.

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“…Published data regarding these tumors are limited further by their varying phenotypes and clinical behavior . Included within the class of sarcomas is angiosarcoma with typically more aggressive behavior to dermatofibroma protuberans often with lower graded histology, thus complicating the treatment algorithm .…”

Section: Introductionmentioning

confidence: 99%

Adjuvant radiation for positive margins in adult head and neck sarcomas is associated with improved survival: Analysis of the National Cancer Database

et al. 2019

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Background Adult head and neck (H&N) sarcomas are a rare malignancy with limited data delineating the role of postoperative radiotherapy (PORT), particularly for a positive surgical margin. There are no randomized trials supporting the use of PORT, therefore treatment trends vary between institutions. A positive margin predicts recurrence and poor survival outcomes. This study uses the National Cancer Database (NCDB) to investigate whether PORT improves overall survival (OS) in adult H&N sarcomas with a positive margin and how utilization has changed. Methods Patients (n = 1142) in the NCDB from 2004‐2013 with adult H&N sarcomas who underwent resection and had a positive margin. Results Factors significantly associated with increased utilization of PORT were: having insurance, salivary gland primary site, high‐risk histology, poor differentiation, and a macroscopic positive margin. Treatment with PORT was associated with improved 5‐year OS for all patients with a positive margin (57% vs 48%; P = .002), both microscopic (57% vs 49%; P = .010) and macroscopic (57% vs 41%; P = .036). Improved OS was significant after controlling for other known covariates on multivariate analysis (HR: 0.76; [0.64‐0.90]; P = .002). Treatment at a community‐based facility was an independent predictor for reduced OS (HR: 1.37; [1.15‐1.64]; P < .001). The percentage utilization (53%) of PORT for these patients did not change significantly over time. Conclusion PORT provides a significant survival benefit for adult H&N sarcoma patients with either a microscopic or macroscopic positive margin; however, PORT is underutilized. Treatment at academic/research cancer programs was associated with increased utilization of PORT and improved survival outcomes.

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Head and neck soft tissue sarcomas: prognostic factors and outcome in a series of patients treated at a single institution

Abstract: Head and neck represent a very critical anatomical site for STS. Achievement of local disease control appears to be crucial, since even LR could be a life-threatening event.

Cited by 69 publications

References 38 publications

The role of systemic therapy in the management of sinonasal cancer: A critical review

The role of systemic therapy in the management of sinonasal cancer: A critical review

Synovial sarcoma: case report

Adjuvant radiation for positive margins in adult head and neck sarcomas is associated with improved survival: Analysis of the National Cancer Database

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