Headache Symptom Versus Headache Disorders: Impact on COVID-19 Survival

Shapiro, Robert E.; Vj, Gallardo; Caronna, Edoardo; Pozo‐Rosich, Patricia

doi:10.2139/ssrn.3781652

Cited by 1 publication

(3 citation statements)

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“…On the other hand, headache and myalgia, reported more often in the younger group, were associated with shorter hospitalization time; additionally, the presence of headache increased the chance of survival. The presence of headache as a protective factor against death due to COVID-19 was confirmed in our study and several others [ 33 , 51 , 52 , 53 , 54 , 55 ]. Headache during COVID-19 may be a marker of the host’s defensive responses to enhance survival [ 53 ].…”

Section: Discussionsupporting

confidence: 90%

“…The presence of headache as a protective factor against death due to COVID-19 was confirmed in our study and several others [ 33 , 51 , 52 , 53 , 54 , 55 ]. Headache during COVID-19 may be a marker of the host’s defensive responses to enhance survival [ 53 ]. Varied pathophysiological mechanisms might mediate this effect.…”

Section: Discussionsupporting

confidence: 90%

“…The cytokine storm is associated with pulmonary inflammation and/or vasoconstriction mediated, among others, by interleukin 6 (Il-6). Il-6 levels were lower and more stable in COVID-19 among patients that reported headache [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Complexity and Diversity of the Neurological Spectrum of SARS-CoV-2 over Three Waves of COVID-19

Jachman-Kapułka,

Zińczuk,

Szymański

et al. 2024

JCM

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Background/Objectives: SARS-CoV-2 continually mutates, with five identified variants. Many neurological manifestations were observed during the COVID-19 pandemic, with differences between virus variants. The aim of this study is to assess the frequency and characteristics of neurological manifestations during COVID-19 in hospitalized patients over three waves in Poland with comparison and analysis correlation with the course of infection. Methods: This retrospective single-center study included 600 consecutive adults with confirmed COVID-19, hospitalized during 3 waves (pre-Delta, Delta and Omicron) in Poland. Demographic and clinical information and neurological manifestations were collected and compared across three periods. Results: The median age of the study group was 68, lower during the Delta wave. In the Omicron period, the disease severity at admission and inflammatory markers concentration were the lowest. Neurological manifestations were observed in 49%. The most common were altered mentation, headache, myalgia, mood disorder, ischemic stroke and encephalopathy. Smell and taste disturbances (STDs) were less frequent in the Omicron period. Neurological complications were predominant in the pre-Delta and Omicron periods. Ischemic stroke was observed more often in pre-Delta period. Altered mentation was related to higher severity at admission, worse lab test results, higher admission to ICU and mortality, while headache reduced mortality. Pre-existing dementia was related to higher mortality. Conclusions: Neurological manifestations of COVID-19 are frequent, with a lower rate of STDs in the Omicron period and more often cerebrovascular diseases in the pre-Delta period. Headache improves the course of COVID-19, while altered mentation, stroke and neurological comorbidities increase severity and mortality.

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