Headspace-gas chromatography-mass spectrometry for the rapid determination of possible biomarkers in urine samples

Abstract

The development of rapid analytical strategies plays a vital role for the research, discovery and confirmation of analytes that can be sensitive biomarkers.

Applications of Electronic-Nose Technologies for Noninvasive Early Detection of Plant, Animal and Human Diseases

“…This information provided biochemical clues to several dysregulated metabolic pathways in HNC patients which could potentially help unravel novel mechanistic insights into HNC-disease pathophysiology by improving understanding of HNC disease mechanisms to facilitate non-invasive biomarker-based approaches to HNC diagnosis. The development of rapid analytical strategies for detecting and identifying urine and other disease biomarkers, including determining limits of detection and limits of quantification of potential biomarkers, have played a vital role in research, discovery and confirmation of biomarker metabolites most associated with specific diseases [46]. The identification of tumor-specific VOC emission signatures from clinical samples of diseased patients has increased significantly in recent years due to studies focusing on the development of a cancer-characteristic "odor fingerprints".…”