Healing at implants installed in osteotomies prepared either with a piezoelectric device or drills: an experimental study in dogs

Fujiwara, Shigeo; Kato, Shingo; Bengazi, Franco; Vélez, Joaquín Urbizo; Tumedei, Margherita; Kotsu, Mitsuo; Botticelli, Daniele

doi:10.1007/s10006-020-00895-y

Cited by 22 publications

(19 citation statements)

References 35 publications

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“…In this paper, we analyzed the osseodensification technique operating in the opposite rotatory direction than the conventional drills due to the use of different drills with an exclusive and patented design. Because of this technique, it is possible the bone condensing toward the osteotomy walls within the same surgery moment of the implant site preparation [ 9 , 10 , 11 , 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

The Effectiveness of Osseodensification Drilling Protocol for Implant Site Osteotomy: A Systematic Review of the Literature and Meta-Analysis

Inchingolo

Bordea

et al. 2021

Materials

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Many different osteotomy procedures has been proposed in the literature for dental implant site preparation. The osseodensification is a drilling technique that has been proposed to improve the local bone quality and implant stability in poor density alveolar ridges. This technique determines an expansion of the implant site by increasing the density of the adjacent bone. The aim of the present investigation was to evaluate the effectiveness of the osseodensification technique for implant site preparation through a literature review and meta-analysis. The database electronic research was performed on PubMed (Medline) database for the screening of the scientific papers. A total of 16 articles have been identified suitable for the review and qualitative analysis—11 clinical studies (eight on animals, three on human subjects), four literature reviews, and one case report. The meta-analysis was performed to compare the bone-to-implant contact % (BIC), bone area fraction occupied % (BAFO), and insertion torque of clockwise and counter-clockwise osseodensification procedure in animal studies. The included articles reported a significant increase in the insertion torque of the implants positioned through the osseodensification protocol compared to the conventional drilling technique. Advantages of this new technique are important above all when the patient has a strong missing and/or low quantity of bone tissue. The data collected until the drafting of this paper detect an improvement when the osseodensification has been adopted if compared to the conventional technique. A significant difference in BIC and insertion torque between the clockwise and counter-clockwise osseodensification procedure was reported, with no difference in BAFO measurements between the two approaches. The effectiveness of the present study demonstrated that the osseodensification drilling protocol is a useful technique to obtain increased implant insertion torque and bone to implant contact (BIC) in vivo. Further randomized clinical studies are required to confirm these pieces of evidence in human studies.

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Section: Introductionmentioning

confidence: 99%

The Effectiveness of Osseodensification Drilling Protocol for Implant Site Osteotomy: A Systematic Review of the Literature and Meta-Analysis

Inchingolo

Bordea

et al. 2021

Materials

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“…Moreover, the optimal synthetic graft should present similar mechanical and physical properties to the replaced bone tissue, simulating the correct ratio of its cortical/cancellous components. Many different scaffold categories have been proposed for bone regeneration: metal graft, polymers, bioglasses and ceramics [ 11 , 16 , 25 , 26 , 27 ]. Tissue engineering for bone regeneration takes advantage of using the synthetic bone scaffolds seeded by multipotent stem cells [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Synthetic Scaffold/Dental Pulp Stem Cell (DPSC) Tissue Engineering Constructs for Bone Defect Treatment: An Animal Studies Literature Review

Lorusso

Inchingolo

Dipalma

et al. 2020

IJMS

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Background: Recently a greater interest in tissue engineering for the treatment of large bone defect has been reported. The aim of the present systematic review and meta-analysis was to investigate the effectiveness of dental pulp stem cells and synthetic block complexes for bone defect treatment in preclinical in vivo articles. Methods: The electronic database and manual search was conducted on Pubmed, Scopus, and EMBASE. The papers identified were submitted for risk-of-bias assessment and classified according to new bone formation, bone graft characteristics, dental pulp stem cells (DPSCs) culture passages and amount of experimental data. The meta-analysis assessment was conducted to assess new bone formation in test sites with DPSCs/synthetic blocks vs. synthetic block alone. Results: The database search identified a total of 348 papers. After the initial screening, 30 studies were included, according to the different animal models: 19 papers on rats, 3 articles on rabbits, 2 manuscripts on sheep and 4 papers on swine. The meta-analysis evaluation showed a significantly increase in new bone formation in favor of DPSCs/synthetic scaffold complexes, if compared to the control at 4 weeks (Mean Diff: 17.09%, 95% CI: 15.16–18.91%, p < 0.01) and at 8 weeks (Mean Diff: 14.86%, 95% CI: 1.82–27.91%, p < 0.01) in rats calvaria bone defects. Conclusion: The synthetic scaffolds in association of DPSCs used for the treatment of bone defects showed encouraging results of early new bone formation in preclinical animal studies and could represent a useful resource for regenerative bone augmentation procedures

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“…Melatonin has been studied due to its anti-inflammatory characteristics and antioxidant properties that could be exerted by different molecular signaling and pathways [256,257]. Melatonin induces the increase and maturation of NK cells, T and B lymphocytes, monocytes, and granulocytes in both bone marrow and other tissues [182,[258][259][260][261][262][263][264][265][266]. In the literature, several articles reported that the administration of melatonin is able to provide an increase in the quantity of macrophages/monocytes and an over-expression of antigenic receptors of the single cell/macrophage lineage [267].…”

Section: Melatoninmentioning

confidence: 99%

The 15-Months Clinical Experience of SARS-CoV-2: A Literature Review of Therapies and Adjuvants

et al. 2021

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Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible for the coronavirus disease of 2019 (COVID-19) that emerged in December 2019 in Wuhan, China, and rapidly spread worldwide, with a daily increase in confirmed cases and infection-related deaths. The World Health Organization declared a pandemic on the 11th of March 2020. COVID-19 presents flu-like symptoms that become severe in high-risk medically compromised subjects. The aim of this study was to perform an updated overview of the treatments and adjuvant protocols for COVID-19. Methods: A systematic literature search of databases was performed (MEDLINE PubMed, Google Scholar, UpToDate, Embase, and Web of Science) using the keywords: “COVID-19”, “2019-nCoV”, “coronavirus” and “SARS-CoV-2” (date range: 1 January 2019 to 31st October 2020), focused on clinical features and treatments. Results: The main treatments retrieved were antivirals, antimalarials, convalescent plasma, immunomodulators, corticosteroids, anticoagulants, and mesenchymal stem cells. Most of the described treatments may provide benefits to COVID-19 subjects, but no one protocol has definitively proven its efficacy. Conclusions: While many efforts are being spent worldwide in research aimed at identifying early diagnostic methods and evidence-based effective treatments, mass vaccination is thought to be the best option against this disease in the near future.

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Healing at implants installed in osteotomies prepared either with a piezoelectric device or drills: an experimental study in dogs

Cited by 22 publications

References 35 publications

The Effectiveness of Osseodensification Drilling Protocol for Implant Site Osteotomy: A Systematic Review of the Literature and Meta-Analysis

The Effectiveness of Osseodensification Drilling Protocol for Implant Site Osteotomy: A Systematic Review of the Literature and Meta-Analysis

Synthetic Scaffold/Dental Pulp Stem Cell (DPSC) Tissue Engineering Constructs for Bone Defect Treatment: An Animal Studies Literature Review

The 15-Months Clinical Experience of SARS-CoV-2: A Literature Review of Therapies and Adjuvants

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