Health Conditions: Effect on Function, Health-Related Quality of Life, and Life Satisfaction After Traumatic Spinal Cord Injury. A Prospective Observational Registry Cohort Study

Rivers, Carly S.; Fallah, Nader; Noonan, Vanessa K.; Whitehurst, David G. T.; Schwartz, Carolyn E.; Finkelstein, Joel; Craven, B. Catharine; Ethans, Karen; O’Connell, Colleen; Truchon, B. Catherine; Ho, Chester; Linassi, Gary; Short, Christine; Tsai, Eve C.; Drew, Brian; Ahn, Henry; Dvorak, Marcel F.; Paquet, Jérôme; Fehlings, Michael G.; Noreau, Luc

doi:10.1016/j.apmr.2017.06.012

Cited by 112 publications

(58 citation statements)

References 44 publications

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“…An unexpected finding of this study is that patients with a severe head or face injury, or a severe torso injury had a better health status than patients without such injuries. Similar findings were reported in other studies of traumatic brain injury and traumatic spinal cord injury. A possible explanation could be that patients' perception of their health status may change after severe injury, owing to a change in internal standards or values, resulting in a surprisingly high health status score.…”

Section: Discussionsupporting

confidence: 87%

Predicting health status in the first year after trauma

Munter

Polinder

Ree

et al. 2019

British Journal of Surgery

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Background: Although mortality rates following major trauma are continuing to decline, a growing number of patients are experiencing long-term disability. The aim of this study was to identify factors associated with health status in the first year following trauma and develop prediction models based on a defined trauma population. Methods: The Brabant Injury Outcome Surveillance (BIOS) study was a multicentre prospective observational cohort study. Adult patients with traumatic injury were included from August 2015 to November 2016 if admitted to one of the hospitals of the Noord-Brabant region in the Netherlands. Outcome measures were EuroQol Five Dimensions 5D-3L (EQ-5D™ utility and visual analogue scale (VAS))and Health Utilities Index (HUI) 2 and 3 scores 1 week and 1, 3, 6 and 12 months after injury. Prediction models were developed using linear mixed models, with patient characteristics, preinjury health status, injury severity and frailty as possible predictors. Predictors that were significant (P < 0⋅050) for one of the outcome measures were included in all models. Performance was assessed using explained variance (R 2 ).Results: In total, 4883 patients participated in the BIOS study (50⋅0 per cent of the total), of whom 3366 completed the preinjury questionnaires. Preinjury health status and frailty were the strongest predictors of health status during follow-up. Age, sex, educational level, severe head or face injury, severe torso injury, injury severity, Functional Capacity Index score, co-morbidity and duration of hospital stay were also relevant in the multivariable models predicting health status. R 2 ranged from 35 per cent for EQ-VAS to 48 per cent for HUI 3.

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Section: Discussionsupporting

confidence: 87%

Predicting health status in the first year after trauma

Munter

Polinder

Ree

et al. 2019

British Journal of Surgery

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“…To analyse these complex association structures, statistical modelling methods can be used [10]. In the SCI literature, we have found only a few studies that use these methods and the ICF model as a framework to analyse relationship structures among components of functioning [11] and interactions with the health condition and contextual factors [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Examining the complexity of functioning in persons with spinal cord injury attending first rehabilitation in Switzerland using structural equation modelling

et al. 2020

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Study design Cross-sectional. Objectives To examine the associations between activities, body structures and functions, and their relationship with aetiology, age and sex in persons with spinal cord injury (SCI) at discharge from first rehabilitation. Setting Swiss SCI Cohort Study (SwiSCI). Methods The study included 390 participants with newly acquired SCI and the International Classification of Functioning, Disability and Health (ICF) as conceptual frame of reference. Body structures were represented by injury level and severity; body functions by cardiovascular, pulmonary, skin, bowel and urinary functions and pain; mental functions by anxiety, depression, optimism and self-esteem; and activities by independence in performing activities of daily living (ADL). Using structural equation modelling (SEM), indirect effects of body structures and functions on independence in performing ADL through mental functions were tested for each mental function separately. For each structural model, fit was assessed using several indices and differences in aetiology, age and sex groups were explored. Results The structural model about optimism showed good fit in all indices; the models about anxiety, depression and selfesteem showed conflicting fit indices, respectively. Within all models, effects on independence in performing ADL were mainly direct. Pain showed significant (P < 0.05) indirect effects on independence in performing ADL within the depression, optimism and self-esteem models. The model about anxiety showed differences in aetiology groups. Conclusions Using an ICF-based modelling approach, this study presents an attempt towards a more comprehensive understanding of functioning in first rehabilitation of persons with SCI, which might be fundamental for rehabilitation planning.

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“…Spinal cord injury (SCI) is one of the most devastating diseases and is still an unresolved event in medicine [2,31,32]. A large number of studies have already proven that treatment with BMSCs, which have an ability to differentiate into the neuronal-like cells, is an effective therapy for SCI [23,[33][34][35].…”

Section: Discussionmentioning

confidence: 99%

“…Spinal cord injury (SCI) has always been considered as a devastating problem that results in catastrophic dysfunction, high disability rate, low mortality rate, and huge cost for the patients. It not only affects the physical and mental health of patients but is also an economic burden on the family [1][2][3]. At present, although various pharmacological therapies are used for SCI, functional recovery is still uncertain [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Coenzyme Q10 Regulation of Apoptosis and Oxidative Stress in H₂O₂ Induced BMSC Death by Modulating the Nrf-2/NQO-1 Signaling Pathway and Its Application in a Model of Spinal Cord Injury

Zhan

Hou

et al. 2019

Oxidative Medicine and Cellular Longevity

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Spinal cord injury (SCI) has always been considered to be a devastating problem that results in catastrophic dysfunction, high disability rate, low mortality rate, and huge cost for the patient. Stem cell-based therapy, especially using bone marrow mesenchymal stem cells (BMSCs), is a promising strategy for the treatment of SCI. However, SCI results in low rates of cell survival and a poor microenvironment, which limits the therapeutic efficiency of BMSC transplantation. Coenzyme Q10 (CoQ10) is known as a powerful antioxidant, which inhibits lipid peroxidation and scavenges free radicals, and its combined effect with BMSC transplantation has been shown to have a powerful impact on protecting the vitality of cells, as well as antioxidant and antiapoptotic compounds in SCI. Therefore, we aimed to evaluate whether CoQ10 could decrease oxidative stress against the apoptosis of BMSCs in vitro and explored its molecular mechanisms. Furthermore, we investigated the protective effect of CoQ10 combined with BMSCs transplanted into a SCI model to verify its ability. Our results demonstrate that CoQ10 treatment significantly decreases the expression of the proapoptotic proteins Bax and Caspase-3, as shown through TUNEL-positive staining and the products of oxidative stress (ROS), while increasing the expression of the antiapoptotic protein Bcl-2 and the products of antioxidation, such as glutathione (GSH), against apoptosis and oxidative stress, in a H 2 O 2induced model. We also identified consistent results from the CoQ10 treatment of BMSCs transplanted into SCI rats in vivo. Moreover, the Nrf-2 signaling pathway was also investigated in order to detail its molecular mechanism, and the results show that it plays an important role, both in vitro and in vivo. Thus, CoQ10 exerts an antiapoptotic and antioxidant effect, as well as improves the microenvironment in vitro and in vivo. It may also protect BMSCs from oxidative stress and enhance their therapeutic efficiency when transplanted for SCI treatment.

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Health Conditions: Effect on Function, Health-Related Quality of Life, and Life Satisfaction After Traumatic Spinal Cord Injury. A Prospective Observational Registry Cohort Study

Cited by 112 publications

References 44 publications

Predicting health status in the first year after trauma

Predicting health status in the first year after trauma

Examining the complexity of functioning in persons with spinal cord injury attending first rehabilitation in Switzerland using structural equation modelling

Coenzyme Q10 Regulation of Apoptosis and Oxidative Stress in H₂O₂ Induced BMSC Death by Modulating the Nrf-2/NQO-1 Signaling Pathway and Its Application in a Model of Spinal Cord Injury

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Health Conditions: Effect on Function, Health-Related Quality of Life, and Life Satisfaction After Traumatic Spinal Cord Injury. A Prospective Observational Registry Cohort Study

Cited by 112 publications

References 44 publications

Predicting health status in the first year after trauma

Predicting health status in the first year after trauma

Examining the complexity of functioning in persons with spinal cord injury attending first rehabilitation in Switzerland using structural equation modelling

Coenzyme Q10 Regulation of Apoptosis and Oxidative Stress in H2O2 Induced BMSC Death by Modulating the Nrf-2/NQO-1 Signaling Pathway and Its Application in a Model of Spinal Cord Injury

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Coenzyme Q10 Regulation of Apoptosis and Oxidative Stress in H₂O₂ Induced BMSC Death by Modulating the Nrf-2/NQO-1 Signaling Pathway and Its Application in a Model of Spinal Cord Injury