Health-related quality of life in patients with psoriatic and rheumatoid arthritis: data from the prospective multicentre NOR-DMARD study compared with Norwegian general population controls

Michelsen, Brigitte; Uhlig, Till; Sexton, Joseph; Heijde, Desirée van der; Hammer, Hilde Berner; Kristianslund, Eirik; Wierød, Ada; Bakland, Gunnstein; Rødevand, Erik; Krøll, Frode; Loge, Jon Håvard; Haugeberg, Glenn; Kvien, Tore K

doi:10.1136/annrheumdis-2018-213286

Cited by 26 publications

(18 citation statements)

References 16 publications

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“…This view that anxiety and depression are a less significant comorbidity in PsA has also recently been supported by two studies not included in the two review articles. In the study by Michelsen et al, HRQoL both for the SF-36 mental and the physical sum scores were significantly lower in PsA patients than in the background population [3]. However, the difference between PsA patients and controls was less for the mental (47.1 vs 50.0) than for the physical sum score (30.5 vs 50.0).…”

Section: Discussionmentioning

confidence: 88%

“…The clinical presentation in psoriatic arthritis (PsA) is heterogeneous involving the musculoskeletal system, nails and skin, and other domains [ 1 ]. Health-related quality of life (HRQoL) has been shown to be impaired among patients with both psoriasis (PsO) [ 2 ] and PsA [ 3 ]; however, impairment has been shown to be greater in PsA [ 4 , 5 ]. For PsA patients to reach optimal improvement in HRQoL, improvement in both skin and musculoskeletal involvement must be achieved [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Psoriatic arthritis: exploring the occurrence of sleep disturbances, fatigue, and depression and their correlates

2020

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Introduction: Sleep disturbances, fatigue, and anxiety/depression in psoriatic arthritis (PsA) may be influenced by skin and musculoskeletal manifestations. All of these in turn affect the psychosocial impact of disease. The objective was to explore the occurrence of sleep disturbances, fatigue, and anxiety/depression in psoriatic arthritis (PsA) patients, and their correlates. Methods: A broad data collection was performed in 137 Norwegian PsA outpatient clinic patients including demographics, disease activity measures for both skin and musculoskeletal involvement, and patient-reported outcome measures. Sleep disturbances and fatigue were defined present if the numeric rating scale (0-10) score was ≥ 5. Anxiety/depression was assessed using a questionnaire (1-3; 1 defined as no anxiety/depression). Descriptive statistics was applied, and associations were explored using univariate and adjusted linear regression analysis. Results: The mean age was 52.3 years, PsA disease duration 8.8 years; 49.6% were men and 54.8% were currently employed/working. The prevalence of sleep disturbances was 38.0%, fatigue 44.5%, and anxiety/depression 38.0%. In adjusted analysis, pain, fatigue, and higher mHAQ were associated with sleep disturbances. Sleep disturbances, pain, and anxiety/depression were associated with fatigue, whereas only fatigue was associated with anxiety/ depression. Conclusions: The prevalence of sleep disturbances, fatigue, and anxiety/depression was frequently reported by PsA patients. No measures reflecting skin involvement or objective measures of musculoskeletal involvement were independently associated with sleep disturbances, fatigue, or anxiety/depression. Our data suggest that patients' perceptions of musculoskeletal involvement (pain or mHAQ) play an important role causing sleep disturbances and fatigue, whereas fatigue in PsA patients is strongly associated with anxiety/depression.

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Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Psoriatic arthritis: exploring the occurrence of sleep disturbances, fatigue, and depression and their correlates

2020

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“…The impact of the disease on HRQoL is comparable to other diseases. In arthritis, a number of studies have demonstrated significantly lower quality of life compared to the general population both in patients with rheumatoid arthritis [33][34][35][36][37] and in those with psoriatic arthritis [38][39][40][41] . This underlines the need for new treatment options.…”

Section: Discussionmentioning

confidence: 99%

Quality of life and patient preferences among Danish patients with ulcerative colitis – results from a survey study

Hagelund¹,

Stallknecht²,

Jensen³

2020

Current Medical Research and Opinion

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Objective: To explore health-related quality of life (HRQoL) and assess preferences for medical treatment attributes to obtain information of the relative importance of the different attributes in a Danish population with ulcerative colitis (UC). Methods: We used data from an online survey collected in March 2018 among people with selfreported UC. A total of 302 eligible respondents answered the HRQoL questionnaires (EuroQol-5 Dimensions (EQ-5D-5L) and the Short Inflammatory Bowel Disease Questionnaire (SIBDQ)), and 212 also completed the discrete choice experiment (DCE). The probability of choosing an alternative from a number of choices in the DCE was estimated using a conditional logit model. Results: The respondents had an average SIBDQ score of 4.5 and an HRQoL score of 0.77, applying the EQ-5D-5L questionnaire. HRQoL correlated with disease severity, and the respondents had lower HRQoL than did a gender-and age-matched subset of the Danish population. The most important medical treatment attribute was efficacy within eight weeks. Additionally, respondents stated a preference for avoiding taking steroids, for fast onset of effect and for oral formulations. Conclusions: HRQoL correlates with disease severity, and patients with UC have lower HRQoL than the general population. The most important treatment attribute was efficacy, but patients also would like to avoid steroids, value fast onset of effect and prefer oral formulations. ARTICLE HISTORY

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“…In the literature, both the psoriasis and the PsA disease are well documented to negatively affect HRQoL. 4 13–15…”

Section: Discussionmentioning

confidence: 99%

Impact of skin, musculoskeletal and psychosocial aspects on quality of life in psoriatic arthritis patients: A cross-sectional study of outpatient clinic patients in the biologic treatment era

Haugeberg¹,

Michelsen²,

Kavanaugh³

2020

RMD Open

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BackgroundIn psoriatic arthritis (PsA), both psoriasis and musculoskeletal manifestations may impair Health-Related Quality of Life (HRQoL). Our objective was to explore the impact of the various disease manifestations and disease consequences, including psychosocial factors, on HRQoL in PsA patients treated in the biologic treatment era.MethodsData collection in the 131 outpatient clinic PsA patients assessed included demographics, disease activity measures for both skin and musculoskeletal involvement and patient-reported outcome (PRO) measures, treatment and psychosocial burden. The skin dimension of quality of life was assessed by the Dermatology Life Quality Index (DLQI) and the overall HRQoL by the 15-Dimensional (15D) Questionnaire.ResultsThe mean age was 51.9 years, PsA disease duration 8.6 years, 50.4% were men, 56.9% were employed/working and 47.7% had ≥1 comorbidities. Prevalence of monotherapy with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) was 36.6% and with biologic DMARDs 12.2% and combination of both 22.9%. Mean DLQI was 3.3 and 15D 0.84. In adjusted analysis, not employed/working, higher scores for fatigue, sleep disturbances, anxiety and depression, Modified Health Assessment Questionnaire and presence of comorbidities were independently associated with impaired HRQoL (lower 15D scores), whereas Psoriasis Area Severity Index (PASI) and DLQI were not. Younger age and higher Psoriatic Arthritis Disease Activity Score and PASI scores were independently associated with impaired skin quality of life (higher DLQI score).ConclusionOur study highlights the negative impact the psychosocial burden, impaired physical function and comorbidities has on reduced HRQoL in PsA outpatients. Thus, to further improve HRQoL in PsA patients, not only physical concerns but also psychological concerns need to be addressed.

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Health-related quality of life in patients with psoriatic and rheumatoid arthritis: data from the prospective multicentre NOR-DMARD study compared with Norwegian general population controls

Abstract: Health-related quality of life was overall similar in patients with RA and patients with PsA-with a tendency to worse scores in PsA-and worse compared with Norwegian general population controls.

Cited by 26 publications

References 16 publications

Psoriatic arthritis: exploring the occurrence of sleep disturbances, fatigue, and depression and their correlates

Psoriatic arthritis: exploring the occurrence of sleep disturbances, fatigue, and depression and their correlates

Quality of life and patient preferences among Danish patients with ulcerative colitis – results from a survey study

Impact of skin, musculoskeletal and psychosocial aspects on quality of life in psoriatic arthritis patients: A cross-sectional study of outpatient clinic patients in the biologic treatment era

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