Healthcare staff perceptions and misconceptions regarding antibody testing in the United Kingdom: implications for the next steps for antibody screening

Robbins, Tim; Kyrou, Ioannis; Laird, Steven; Morgan, Nina; Anderson, Neil; Imray, Chris; Patel, Kiran; Sambandam, Sankar; Randeva, Harpal S.; Jones, Ceri

doi:10.1016/j.jhin.2020.11.019

Cited by 7 publications

(6 citation statements)

References 14 publications

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“…(2) 45 cross-sectional or cohort studies [18][19][20][21][22][23]25,26,29,31,32,35,37,[39][40][41][42][43][44]47,48,[51][52][53][54][55][56][58][59][60][61][62][63][64][67][68][69]71,[74][75][76][77][78][79][80] characterizing the antibody response (i.e., antibody types, levels, and duration) among adults with SARS-CoV-2 infection; and 317 studies validating the diagnostic performance of one or more immunoassays. 16,17,24,27,…”

Section: Study Characteristicsmentioning

confidence: 99%

“…In a survey of 560 British healthcare workers, 15 percent of whom had a history of RT-PCR confirmed SARS-CoV-2, 11 percent (61) indicated that they would view social distancing as less important and 31 percent (175) would be "happier to visit friends and relatives." 53 No studies have documented actual behavior change related to knowledge of antibody status.…”

Section: Key Question 4: Unintended Consequences Of Antibody Testing mentioning

confidence: 99%

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Antibody Response Following SARS-CoV-2 Infection and Implications for Immunity: A Rapid Living Review

Mackey

Arkhipova-Jenkins

Armstrong

et al. 2021

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 Evidence suggests that the majority of adults develop detectable levels of immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies following infection with SARS-CoV-2 (moderate strength of evidence* [SoE]).  IgM levels peak approximately 20 days after symptom onset or RT-PCR diagnosis and subsequently decline. IgG levels peak approximately 25 days after symptom onset or RT-PCR diagnosis and may remain detectable for at least 120 days (moderate SoE*).  Almost all adults develop neutralizing antibodies in response to SARS-CoV-2 infection, and these antibodies may remain detectable for at least 152 days (low SoE*).  A small percentage of people do not develop antibodies in response to SARS-CoV-2 infection for reasons that are largely unclear but may be related to less severe disease or absence of symptoms.  Antibody prevalence does not appear to vary by age or sex, but older age may be associated with higher antibody levels (low SoE*). Non-White race may be associated with higher antibody prevalence and levels (low SoE*). COVID-19 severity and presence of symptoms may also be associated with higher antibody prevalence or levels (low SoE*). More evidence is needed to draw stronger conclusions regarding how the antibody response varies by patient characteristics and disease factors.  Studies to date have not established the relationship between the development of antibodies after RT-PCR-diagnosed SARS-CoV-2 infection and the risk of reinfection. Studies based on index serologic testing suggest that the presence of antibodies is associated with a lower risk of a subsequent positive SARS-CoV-2 RT-PCR test.

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Section: Study Characteristicsmentioning

confidence: 99%

Section: Key Question 4: Unintended Consequences Of Antibody Testing mentioning

confidence: 99%

Antibody Response Following SARS-CoV-2 Infection and Implications for Immunity: A Rapid Living Review

Mackey

Arkhipova-Jenkins

Armstrong

et al. 2021

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show abstract

“…The study survey was designed by a multi-disciplinary collaboration of healthcare professionals and was modelled on a previously developed and published survey study considering uptake of COVID-19 antibody testing [19], which provided some validation of the survey questions; however, a fully validated survey for this questionnaire was not available. Ethical approval was granted through the Trust's COVID-19 ethics committee (GAFREC ID: GF0427).…”

Section: Methodsmentioning

confidence: 99%

Healthcare Staff Perceptions Following Inoculation with the BNT162b2 mRNA COVID-19 Vaccine at University Hospitals Coventry & Warwickshire NHS Trust

Robbins

Kyrou

Clark

et al. 2021

IJERPH

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Background: COVID-19 vaccination programmes offer hope for a potential end to the acute phase of the COVID-19 pandemic. We present perceptions following from a cohort of healthcare staff at the UK NHS hospital, which first initiated the BNT162b2 mRNA COVID-19 (“Pfizer”) vaccination program. Methods: A paper-based survey regarding perceptions on the BNT162b2 mRNA COVID-19 vaccine was distributed to all healthcare workers at the University Hospitals Coventry & Warwickshire NHS Trust following receipt of the first vaccine dose. Results: 535 healthcare workers completed the survey, with a 40.9% response rate. Staff felt privileged to receive a COVID-19 vaccine. Staff reported that they had minimised contact with patients with confirmed or suspected COVID-19. Reported changes to activity following vaccination both at work and outside work were guarded. Statistically significant differences were noted between information sources used by staff groups and between groups of different ethnic backgrounds to inform decisions to receive vaccination. Conclusions: NHS staff felt privileged to receive the COVID-19 vaccine, and felt that their actions would promote uptake in the wider population. Concerns regarding risks and side effects existed, but were minimal. This research can be used to help inform strategies driving wider vaccine uptake amongst healthcare staff and the public.

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“…Robbins et al. also made an interesting observation in a survey of HCW attitudes to antibody testing, expressing concern HCW might misinterpret their seropositivity as a reason to be less compliant with IPC precautions [ 23 ].…”

mentioning

confidence: 99%

“…Moreover, the fundamental value of seroprevalence studies were questioned by Lippi, owing to the variable accuracy of tests [22]. Robbins et al also made an interesting observation in a survey of HCW attitudes to antibody testing, expressing concern HCW might misinterpret their seropositivity as a reason to be less compliant with IPC precautions [23].…”

mentioning

confidence: 99%

Lessons learned from the COVID-19 pandemic through the JHI and IPIP

Prescott

Gray

Mahida

et al. 2022

Journal of Hospital Infection

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Healthcare staff perceptions and misconceptions regarding antibody testing in the United Kingdom: implications for the next steps for antibody screening

Cited by 7 publications

References 14 publications

Antibody Response Following SARS-CoV-2 Infection and Implications for Immunity: A Rapid Living Review

Antibody Response Following SARS-CoV-2 Infection and Implications for Immunity: A Rapid Living Review

Healthcare Staff Perceptions Following Inoculation with the BNT162b2 mRNA COVID-19 Vaccine at University Hospitals Coventry & Warwickshire NHS Trust

Lessons learned from the COVID-19 pandemic through the JHI and IPIP

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