Healthy brain aging and delayed dementia in Texas rural elderly

Basu, Tanisha; Sehar, Ujala; Malhotra, Keya; Culberson, John; Khan, Hafiz; Morton, Hallie; Orlov, Erika; Brownell, Malcolm; Reddy, P. Hemachandra

doi:10.1016/j.arr.2023.102047

Cited by 10 publications

(5 citation statements)

References 81 publications

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“…Midlife obesity is associated with an increased risk of dementia and Alzheimer’s disease in later life ( Kivipelto et al, 2005 ), while evidence suggests that hyperinsulinemia and insulin resistance could be crucial factors link MetS and Alzheimer’s disease ( Razay et al, 2007 ). Though definitive conclusions await further detailed investigations, it is indisputable that adopting a healthy lifestyle, including a balanced diet, regular physical activity, efficient stress management, adequate sleep, and appropriate antioxidant supplementation, can mitigate oxidative stress, augment endothelial function, and reduce inflammatory responses ( Basu et al, 2023 )—essential steps in slowing the aging process and preventing dementia.…”

Section: Discussionmentioning

confidence: 99%

Dementia and metabolic syndrome: a bibliometric analysis

Peng,

Yang,

et al. 2024

Front. Aging Neurosci.

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BackgroundDementia is a progressive neurodegenerative condition, while metabolic syndrome (MetS) is characterized by a combination of metabolic abnormalities such as hypertension, high blood sugar, and obesity. There exists a connection and overlap between the two conditions in certain aspects, and both are influenced to varying degrees by the process of aging. This study presents an overview of the current research landscape regarding dementia and MetS through bibliometric analysis.MethodsA systematic search was conducted to retrieve relevant literature on dementia and MetS published between 1 January 2000, and 30 November 2023, from the Web of Science Core Collection database. Various bibliometric tools, including VOSviewer, CiteSpace, and the R software package “bibliometrix,” were utilized for analysis.ResultsA total of 717 articles were identified, showing an upward trend in annual publications. Leading contributors included the United States, Italy, and China, with institutions such as the University of California System at the forefront. The Journal of Alzheimer’s Disease emerged as the top publisher, while research published in Neurology garnered significant citations. Noteworthy authors encompassed Panza, Francesco; Frisardi, Vincenza; and Feldman, Eva L, with Kristine Yaffe being the most cited author (280 citations). Recent studies have focused on themes like “gut microbiota,” “neuroinflammation,” “fatty acids,” and “microglia.”ConclusionThis bibliometric analysis summarizes the foundational knowledge structure in the realm of dementia and MetS from 2000 to 2023. By highlighting current research frontiers and trending topics, this analysis serves as a valuable reference for researchers in the field.

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Section: Discussionmentioning

confidence: 99%

Dementia and metabolic syndrome: a bibliometric analysis

Peng,

Yang,

et al. 2024

Front. Aging Neurosci.

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“…The risk of dementia and cognitive impairment varies greatly within a uniform age group, underscoring the importance of accurate predictors to characterize the progression of dementia [ 8 ]. There is evidence to suggest that dementia may be influenced by a range of modifiable factors, including obesity, sleep duration and quality, levels of physical activity, diet, social interactions, and the presence of co-morbidities [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Long Objective Sleep Duration is a Marker of Cognitive Impairment in Older Adults: Findings from the Cretan Aging Cohort

Basta,

Bouloukaki,

Skourti

et al. 2024

Journal of Alzheimer's Disease Reports

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We examined associations between objective sleep duration and cognitive status in older adults initially categorized as cognitively non-impaired (CNI, n = 57) or diagnosed with mild cognitive impairment (MCI, n = 53). On follow-up, 8 years later, all participants underwent neuropsychiatric/neuropsychological evaluation and 7-day 24-h actigraphy. On re-assessment 62.7% of participants were cognitively declined. Patients who developed dementia had significantly longer night total sleep time (TST) than persons with MCI who, in turn, had longer night TST than CNI participants. Objective long sleep duration is a marker of worse cognitive status in elderly with MCI/dementia and this association is very strong in older adults.

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“…Cognitive health will be measured by administrating the Montreal Cognitive Assessment (MoCA). The research plan under consideration is a continuing initiative within our laboratory [ 8 ]. Additionally, in the wet lab, we will also study circulating cell-free DNA from serum samples and the double-stranded breaks in the buffy-coats from study participants (cognitively healthy and mild cognitively impaired subjects and AD patients).…”

mentioning

confidence: 99%

“…Therefore, developing effective preventative measures in our elderly and emphasizing the importance of a normal healthy brain and body, may help delay or even prevent cognitive decline. Ongoing health aging study aims to investigate the possible influence of biological, sociodemographic, and lifestyle factors on the occurrence of chronic diseases and dementia in the aging population of West Texas [3][4][5][6][7][8].…”

mentioning

confidence: 99%

“…The proposed research aims to identify the determinants influencing cognitive health in individuals aged 60-90, distinguishing those aging without cognitive impairments from those developing chronic conditions and cognitive decline. While a small percentage of early-onset Alzheimer's cases result from specific genetic mutations, causal factors for most late-onset cases remain elusive, potentially involving lifestyle elements such as diet, exercise, environmental exposure, genetics [1], and other variables [8][9][10]. An unhealthy diet and physical inactivity are particularly implicated in the progression of AD.…”

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confidence: 99%

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Is Effective Recruitment Strategy Critical to Assess Brain Cognitive Function of Super Agers in Rural West Texas

Brownell,

Sehar,

Kshirsagar

et al. 2024

Journal of Alzheimer's Disease Reports

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Our commentary aims to elucidate the importance of participant recruitment strategy in healthy brain aging study, particularly in rural West Texas, where more than 50% of the population are Hispanics and Latinos. The objective of our health aging study is to investigate the possible influence of biological, sociodemographic, and lifestyle factors on the occurrence of chronic diseases and dementia in the aging populations of West Texas. The success of this initiative is, in large part, reliant on high-quality, effective recruitment of participants. To that end, we propose an increase in our strategic recruitment efforts for both healthy, cognitively superior agers as well as those with mild cognitive impairment and patients with Alzheimer’s disease in rural west Texas. We discussed, multi-advertising approaches, including ads in the local newspapers, local TV Channels and poster boards in senior centers.

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Healthy brain aging and delayed dementia in Texas rural elderly

Cited by 10 publications

References 81 publications

Dementia and metabolic syndrome: a bibliometric analysis

Dementia and metabolic syndrome: a bibliometric analysis

Long Objective Sleep Duration is a Marker of Cognitive Impairment in Older Adults: Findings from the Cretan Aging Cohort

Is Effective Recruitment Strategy Critical to Assess Brain Cognitive Function of Super Agers in Rural West Texas

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