Healthy individuals maintain adaptive stimulus evaluation under predictable and unpredictable threat

Klinkenberg, Isabelle; Rehbein, Maimu Alissa; Steinberg, Christian; Klahn, Anna Luisa; Zwanzger, Peter; Zwitserlood, Pienie; Junghöfer, Markus

doi:10.1016/j.neuroimage.2016.05.041

Cited by 14 publications

(13 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increasing threat unpredictability led to increasing dlPFC activity during visual processing. Although parts of the present sample have already been reported previously, the effect of threat predictability on the right dlPFC appears to be consistent over different samples including two clinical groups (Klahn et al, 2016, Klinkenberg et al, 2016). The more unpredictable a threat, the more frontal capacities are engaged into cognitive, e.g.…”

Section: Discussionsupporting

confidence: 71%

“…The modified NPU paradigm (Klinkenberg et al, 2016) consisted of three consecutive runs presented in randomized order across subjects. In each run, a different set of 56 greyscaled male and female faces with fearful or neutral expressions (i.e.…”

Section: Methodsmentioning

confidence: 99%

“…In each run, a different set of 56 greyscaled male and female faces with fearful or neutral expressions (i.e. 28 faces per face expression), randomly chosen from a total compilation of 236 facial stimuli (see Klinkenberg et al, 2016 for more details regarding stimulus choice), was presented four times resulting in a total presentation of 112 facial stimuli per run and experimental condition (stimulus duration: 500 ms; jittered ITI: 825-1325 ms). In the predictable (P) and unpredictable (U) runs, a video (760 ms duration) of a rapidly appearing monster paired with an aversive scream served as threat stimulus and was presented four times per run.…”

Section: Methodsmentioning

confidence: 99%

“…Prior to and after MEG-measurement, participants completed a SAM-rating regarding valence and arousal for all fearful and neutral faces, respectively. For more details on the experimental paradigm see (Klinkenberg et al, 2016). …”

Section: Methodsmentioning

confidence: 99%

“…While phasic fear has been linked to activity of the central amygdala, sustained anxiety predominately activated the bed nucleus of the stria terminalis (BNST), anterior cingulate cortex (ACC), and insula (Herrmann et al, 2016, Muensterkoetter et al, 2015). Using a novel paradigm based on the NPU design (Klahn et al, 2016, Klinkenberg et al, 2016) in an MEG study focusing on cortical activation patterns, we recently showed that the dorsolateral prefrontal cortex (dlPFC) modulated threat predictability while parietal cortex activation dissociated between threat and safety conditions. Individuals with specific phobia were characterized by reduced overall parietal processing compared to non-anxious controls (Klahn et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Commonalities and differences in the neural substrates of threat predictability in panic disorder and specific phobia

Klahn

Klinkenberg²,

Lueken

et al. 2017

NeuroImage: Clinical

Self Cite

View full text Add to dashboard Cite

Different degrees of threat predictability are thought to induce either phasic fear or sustained anxiety. Maladaptive, sustained anxious apprehension is thought to result in overgeneralization of anxiety and thereby to contribute to the development of anxiety disorders. Therefore, differences in threat predictability have been associated with pathological states of anxiety with specific phobia (SP) representing phasic fear as heightened response to predictable threat, while panic disorder (PD) is characterized by sustained anxiety (unpredictable threat) and, as a consequence, overgeneralization of fear. The present study aimed to delineate commonalities and differences in the neural substrates of the impact of threat predictability on affective processing in these two anxiety disorders.Twenty PD patients, 20 SP patients and 20 non-anxious control subjects were investigated with an adapted NPU-design (no, predictable, unpredictable threat) using whole-head magnetoencephalography (MEG).Group independent neural activity in the right dlPFC increased with decreasing threat predictability. PD patients showed a sustained hyperactivation of the vmPFC under threat and safety conditions. The magnitude of hyperactivation was inversely correlated with PDs subjective arousal and anxiety sensitivity. Both PD and SP patients revealed decreased parietal processing of affective stimuli. Findings indicate overgeneralization between threat and safety conditions and increased need for emotion regulation via the vmPFC in PD, but not SP patients. Both anxiety disorders showed decreased activation in parietal networks possibly indicating attentional avoidance of affective stimuli. Present results complement findings from fear conditioning studies and underline overgeneralization of fear, particularly in PD.

show abstract

Section: Discussionsupporting

confidence: 71%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Commonalities and differences in the neural substrates of threat predictability in panic disorder and specific phobia

Klahn

Klinkenberg²,

Lueken

et al. 2017

NeuroImage: Clinical

Self Cite

View full text Add to dashboard Cite

show abstract

Exercise decreases defensive responses to unpredictable, but not predictable, threat

et al. 2018

View full text Add to dashboard Cite

show abstract

Individual differences in contextual threat generalisation and uncertainty: The role of intolerance of uncertainty

Zhou

Huang

et al. 2023

Int J Psychol

View full text Add to dashboard Cite

Threat generalisation is an adaptive process that is essential for individual survival. In contrast, over‐generalisation is a pathological process that underlies the development of anxiety disorders. Intolerance of uncertainty (IU) is an individual characteristic known to influence threat generalisation by altering the responses to threat in uncertain situations. However, how it affects contextual threat generalisation remains unclear. Here, we used a novel paradigm to investigate whether contextual threat generalisation varied between individuals depending on their IU level (high or low) and the predictability of a situation (predictable or unpredictable). We analysed shock expectancy in 82 participants (age: 18–27 years) during threat acquisition and generalisation. Results showed that compared with the low IU group, the high IU group exhibited increased contextual threat generalisation to threat‐related cues in unpredictable situation. These findings suggest that IU could be a marker for anxiety disorder susceptibility, as well as a target for anxiety treatment.

show abstract

Healthy individuals maintain adaptive stimulus evaluation under predictable and unpredictable threat

Cited by 14 publications

References 64 publications

Commonalities and differences in the neural substrates of threat predictability in panic disorder and specific phobia

Commonalities and differences in the neural substrates of threat predictability in panic disorder and specific phobia

Exercise decreases defensive responses to unpredictable, but not predictable, threat

Individual differences in contextual threat generalisation and uncertainty: The role of intolerance of uncertainty

Contact Info

Product

Resources

About