Healthy Vascular Aging

Currie, Gemma; Delles, Christian

doi:10.1161/hypertensionaha.117.09122

Cited by 18 publications

(32 citation statements)

References 12 publications

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“…5 Thus, the prevalence of arterial damage and not average CIMT or PWV values was assumed to be more reasonable to assess vascular health in migraineurs. We chose this approach because abnormally high values of the studied markers are more likely to be associated with increased individual risk for future CVD than the average values in a specified population.…”

Section: Discussionmentioning

confidence: 99%

“…5 Moreover, vascular stiffening in arteriosclerosis is intrinsically related to the atherosclerosis process, 6 possibly representing a continuum. [4][5][6] Although the relationship between oxidative stress and migraine is uncertain, 8 pathogenic migraine mechanisms can be generators of oxidative stress. [4][5][6] Although the relationship between oxidative stress and migraine is uncertain, 8 pathogenic migraine mechanisms can be generators of oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

“…[4][5][6] Although the relationship between oxidative stress and migraine is uncertain, 8 pathogenic migraine mechanisms can be generators of oxidative stress. 5 Carotid artery imaging via ultrasonography is a noninvasive method that is widely used to assess the subclinical structural markers of vascular damage. 5 Carotid artery imaging via ultrasonography is a noninvasive method that is widely used to assess the subclinical structural markers of vascular damage.…”

Section: Introductionmentioning

confidence: 99%

“…4 Furthermore, arteriosclerosis is a broader vascular dysfunction which also involves structural remodeling of the arteries, mainly due to vascular aging. 5 Moreover, vascular stiffening in arteriosclerosis is intrinsically related to the atherosclerosis process, 6 possibly representing a continuum. 7 Vascular diseases related to both arteriosclerotic and atherosclerotic processes probably result from a lifelong exposure to vascular risk factors and concurrent damage to the endothelium, resulting in endothelial dysfunction due to oxidative stress and predisposition to CVD.…”

Section: Introductionmentioning

confidence: 99%

“…7 Vascular diseases related to both arteriosclerotic and atherosclerotic processes probably result from a lifelong exposure to vascular risk factors and concurrent damage to the endothelium, resulting in endothelial dysfunction due to oxidative stress and predisposition to CVD. [4][5][6] Although the relationship between oxidative stress and migraine is uncertain, 8 pathogenic migraine mechanisms can be generators of oxidative stress. 9 Pulse wave velocity (PWV) evaluation and carotid artery imaging, among other parameters, allow mapping of the arterial disease process and can thus be used for the assessment of the vascular phenotype.…”

Section: Introductionmentioning

confidence: 99%

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Migraine and Markers of Carotid Atherosclerosis in Middle‐Aged Women: A Cross‐Sectional Study

et al. 2018

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Objective This study evaluated the association between migraine and the markers of carotid artery disease. Background Migraine increases the risk of cardiovascular events, but its relationship with vascular dysfunction is unclear. Methods In this cross‐sectional study, middle‐aged women with no known cardiovascular diseases underwent clinical, neurological, and laboratory evaluations; pulse wave velocity (PWV) assessment; and carotid artery ultrasonography. We divided the participants based on the presence of migraine and, further, based on the type of migraine. Associations between migraine and carotid thickening (intima‐media thickness >0.9 mm), carotid plaques, or arterial stiffening (PWV >10 m/s) were evaluated using a multiple regression analysis. Results The study comprised 112/277 (40%) women with migraine, of whom 46/277 (17%) reported having an aura. Compared to the non‐migraineurs, the migraine with aura group had an increased risk of diffuse carotid thickening (3/46 [6.8%] vs 2/165 [1.3%], adjusted OR = 7.12, 95% CI 1.05–48.49). Migraine without aura was associated with a low risk of carotid plaques (3/66 [4.7%] vs 26/165 [16.7%], adjusted OR = 0.28, 95% CI 0.08–0.99) and arterial stiffening (21/66 [34.4%] vs 82/165 [51.2%], adjusted OR = 0.39, 95% CI 0.19–0.79). There were no correlations between migraine characteristics and arterial stiffness or carotid thickness measurements. Conclusion Migraine with aura is associated with an increased risk of carotid thickening, and migraine without aura is associated with a low risk of carotid plaques and arterial stiffening.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Migraine and Markers of Carotid Atherosclerosis in Middle‐Aged Women: A Cross‐Sectional Study

et al. 2018

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Differences in Cardiovascular Aging in Men and Women

Kane

Howlett

2018

Advances in Experimental Medicine and Biology

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Cardiovascular diseases increase dramatically with age in both men and women. While it is clear that advanced age allows more time for individuals to be exposed to risk factors in general, there is strong evidence that age itself is a major independent risk factor for cardiovascular disease. Indeed, there are distinct age-dependent cellular, structural, and functional changes in both the heart and blood vessels, even in individuals with no clinical evidence of cardiovascular disease. Studies in older humans and in animal models of aging indicate that this age-related remodeling is maladaptive. An emerging view is that the heart and blood vessels accumulate cellular and subcellular deficits with age and these deficits increase susceptibility to disease in older individuals. Aspects of this age-dependent remodeling of the heart and blood vessels differ between the sexes. There is also new evidence that these maladaptive changes are more prominent in older animals and humans with a high degree of frailty. These observations may help explain why men and women are susceptible to different cardiovascular diseases as they age and why frail older adults are most often affected by these diseases.

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