Hearing Loss After Cisplatin: Oxidative Stress Pathways and Potential for Protection

Ototoxicity diagnosis and management has historically been approached using a variety of methods. However, in recent years a consensus on useful and practical approaches has been developed through clinical guidelines of the American Speech Language Hearing Association, the American Academy of Audiology, and multiple clinical trials published in peer-reviewed literature. Some of the guidelines and approaches are used to detect and monitor ototoxicity, while others are used to grade adverse events. Some of the audiologic measures are primary, while others are adjunct measures and may be tailored to the specific needs of the patient or clinical trial. For some types of monitoring, such as drug-induced tinnitus or dizziness, validated paper survey instruments can be both sensitive and easy for fragile patients. This review addresses the characteristics of some of the most common clinical ototoxins and the most common methods for detecting and monitoring ototoxicity in clinical practice and clinical trials.

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Hearing Loss After Cisplatin: Oxidative Stress Pathways and Potential for Protection

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Cited by 4 publications

References 148 publications

Current Issues in Clinical and Translational Research in the Hearing Sciences, Audiology, and Otolaryngology

Current Issues in Clinical and Translational Research in the Hearing Sciences, Audiology, and Otolaryngology

Cisplatin-Induced Hearing Loss

Drug-Induced Ototoxicity: Diagnosis and Monitoring

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