“…If the ratio were 10, the traditional dose of 12 Gy of SRS (Table 5) Our data suggest that the radiobiology of VSs is still unclear; genetic markers determining radiosensitivity need further investigation. 46 In any case, various reports demonstrate that SRS or fractionated stereotactic radiotherapy can achieve a tumor control rate of about 90%-96% treating VS, 7,9,14,16,18,23,28,29,33,34 and a small percentage of progressive VSs after irradiation tend to exist in every study group. So far, we are unable to predict, on the basis of clinical history, neurological status, and neuroradiological and functional investigations, whether a particular patient will belong to the category of responders or nonresponders.…”