2012
DOI: 10.1016/j.jocn.2012.01.015
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Hearing preservation after LINAC radiosurgery and LINAC radiotherapy for vestibular schwannoma

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Cited by 25 publications
(14 citation statements)
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“…If the ratio were 10, the traditional dose of 12 Gy of SRS (Table 5) Our data suggest that the radiobiology of VSs is still unclear; genetic markers determining radiosensitivity need further investigation. 46 In any case, various reports demonstrate that SRS or fractionated stereotactic radiotherapy can achieve a tumor control rate of about 90%-96% treating VS, 7,9,14,16,18,23,28,29,33,34 and a small percentage of progressive VSs after irradiation tend to exist in every study group. So far, we are unable to predict, on the basis of clinical history, neurological status, and neuroradiological and functional investigations, whether a particular patient will belong to the category of responders or nonresponders.…”
Section: Discussionmentioning
confidence: 97%
“…If the ratio were 10, the traditional dose of 12 Gy of SRS (Table 5) Our data suggest that the radiobiology of VSs is still unclear; genetic markers determining radiosensitivity need further investigation. 46 In any case, various reports demonstrate that SRS or fractionated stereotactic radiotherapy can achieve a tumor control rate of about 90%-96% treating VS, 7,9,14,16,18,23,28,29,33,34 and a small percentage of progressive VSs after irradiation tend to exist in every study group. So far, we are unable to predict, on the basis of clinical history, neurological status, and neuroradiological and functional investigations, whether a particular patient will belong to the category of responders or nonresponders.…”
Section: Discussionmentioning
confidence: 97%
“…Evaluating success after STR is a challenge due to changes in technology, treatment protocols (radiation dose), and the relatively short duration of follow-up reported and variability in how treatment success is defined. Current studies have a mean follow-up of less than 5 years [31,36,[46][47][48][49][50], and long-term outcomes are often based on actuarial estimates of tumor control and hearing preservation rates [41-43, 46, 47]. There is also significant variability in how successful tumor control or hearing preservation is defined.…”
Section: Discussionmentioning
confidence: 99%
“…Stereotactic radiation may be delivered in a single dose, termed fractionated stereotactic radiosurgery or in fractions, termed stereotactic radiotherapy. Tumor control rates are similar between both modalities, and there are conflicting reports as to whether one strategy is superior in terms of hearing preservation [33,[36][37][38][39][40]. Initially, VS were treated with higher doses (16-20 Gy) of radiation, and most tumors were found to decrease in size.…”
Section: Stereotactic Radiationmentioning
confidence: 99%
“…One of the purported reasons for offering irradiation early for relatively small AN is to preserve what is described as ''useful hearing'' (defined as Gardner Robertson grades I & II) [4,25,26]. The justification is based on data showing larger proportion of patients with smaller tumours retaining useful hearing at any time after treatment compared with patients with larger tumours.…”
Section: Hearingmentioning
confidence: 99%