Heart Enhancers: Development and Disease Control at a Distance

Yuan, Xuefei; Scott, Ian C.; Wilson, Michael D.

doi:10.3389/fgene.2021.642975

Cited by 4 publications

(4 citation statements)

References 347 publications

(479 reference statements)

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“…We have left the discussions on the dynamics of enhancer–promoter looping in specific biological settings outside the scope of this review. Several recent articles have provided up-to-date perspectives in this regard for various systems, including lymphocyte development [ 250 , 251 ], heart development and disease [ 252 ], and cancer [ 253 ].…”

Section: Enhancer–promoter Communication In Three Dimensionsmentioning

confidence: 99%

Transcriptional enhancers and their communication with gene promoters

Ray-Jones

Spivakov

2021

Cell. Mol. Life Sci.

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Transcriptional enhancers play a key role in the initiation and maintenance of gene expression programmes, particularly in metazoa. How these elements control their target genes in the right place and time is one of the most pertinent questions in functional genomics, with wide implications for most areas of biology. Here, we synthesise classic and recent evidence on the regulatory logic of enhancers, including the principles of enhancer organisation, factors that facilitate and delimit enhancer–promoter communication, and the joint effects of multiple enhancers. We show how modern approaches building on classic insights have begun to unravel the complexity of enhancer–promoter relationships, paving the way towards a quantitative understanding of gene control.

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Section: Enhancer–promoter Communication In Three Dimensionsmentioning

confidence: 99%

Transcriptional enhancers and their communication with gene promoters

Ray-Jones

Spivakov

2021

Cell. Mol. Life Sci.

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“…Some of these surviving cardiomyocytes also expressed MEF2C, which controls cardiac morphogenesis and myogenesis. 24 It has been previously demonstrated that adult mammalian cardiomyocytes would undergo dedifferentiation, proliferation, and redifferentiation after ischemic injury in vitro . 25 The expression of MEF2C in these surviving cardiomyocytes would suggest that the change of cardiomyocytes from being rod-shaped to round-shaped might be reversible with suitable changes in the microenvironment.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…25 The expression of MEF2C in these surviving cardiomyocytes would suggest that the change of cardiomyocytes from being rod-shaped to round-shaped might be reversible with suitable changes in the microenvironment. 7,24 ECM is the key component in the microenvironment, and ECM alteration disrupts the supporting structure for cell-to-cell communication. 7,14,23,26 We found here that the ECM disruption involved excessive collagen deposition in the ECM, furthering the disconnection between cardiomyocytes.…”

Section: Discussionmentioning

confidence: 99%

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Extracellular matrix remodeling is associated with the survival of cardiomyocytes in the subendocardial region of the ischemic myocardium

Chu

Xiao

Song

et al. 2021

Exp Biol Med (Maywood)

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A significant amount of cardiomyocytes in subendocardial region survive from ischemic insults. In order to understand the mechanism by which these cardiomyocytes survive, the present study was undertaken to examine changes in these surviving cardiomyocytes and their extracellular matrix. Male C57BL/6 mice aged 8–12 weeks old were subjected to a permanent left anterior descending coronary artery ligation to induce ischemic injury. The hearts were collected at 1, 4, 7, or 28 days after the surgery and examined by histology. At day 1 after left anterior descending ligation, there was a significant loss of cardiomyocytes through apoptosis, but a proportion of cardiomyocytes were surviving in the subendocardial region. The surviving cardiomyocytes were gradually changed from rod-shaped to round-shaped, and appeared disconnected. Connexin 43, an important gap junction protein, was significantly decreased, and collagen I and III deposition was significantly increased in the extracellular matrix. Furthermore, lysyl oxidase, a copper-dependent amine oxidase catalyzing the cross-linking of collagens, was significantly increased in the extracellular matrix, paralleled with the surviving cardiomyocytes. Inhibition of lysyl oxidase activity reduced the number of surviving cardiomyocytes. Thus, the extracellular matrix remodeling is correlated with the deformation of cardiomyocytes, and the electrical disconnection between the surviving cardiomyocytes due to connexin 43 depletion and the increase in lysyl oxidase would help these deformed cardiomyocytes survive under ischemic conditions.

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Downregulation of NUP93 aggravates hypoxia-induced death of cardiomyocytes in vitro through abnormal regulation of gene transcription

Pan

Song

et al. 2023

Acta Pharmacol Sin

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Heart Enhancers: Development and Disease Control at a Distance

Cited by 4 publications

References 347 publications

Transcriptional enhancers and their communication with gene promoters

Transcriptional enhancers and their communication with gene promoters

Extracellular matrix remodeling is associated with the survival of cardiomyocytes in the subendocardial region of the ischemic myocardium

Downregulation of NUP93 aggravates hypoxia-induced death of cardiomyocytes in vitro through abnormal regulation of gene transcription

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