Heart Rate Variability and Heart Rate Turbulence in Patients with Hematologic Malignancies Subjected to High‐Dose Chemotherapy in the Course of Hematopoietic Stem Cell Transplantation

Poręba, Małgorzata; Poręba, Rafał; Gać, Paweł; Usnarska−Zubkiewicz, Lidia; Pilecki, Witold; Piotrowicz, Ewa; Piotrowicz, Ryszard; Rusiecki, Lesław; Kuliczkowski, Kazimierz; Mazur, Grzegorz; Sobieszczańska, Małgorzata

doi:10.1111/anec.12108

Cited by 17 publications

(12 citation statements)

References 26 publications

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“…The worsening of HRV parameters in our study persisted until the end of chemotherapy. Our findings are consistent with those of other researchers, who showed a decrease in HRV parameters [7], suggesting the possibility of worsening sympathetic activation after drug infusion. It should be noted that Holter ECG was performed immediately after drug infusion, and many side effects of anti-cancer drugs are more strongly expressed in this period than a few weeks after administration.…”

Section: Discussionsupporting

confidence: 93%

Heart rate variability during and after chemotherapy with anthracycline in patients with breast cancer

et al. 2018

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Section: Discussionsupporting

confidence: 93%

Heart rate variability during and after chemotherapy with anthracycline in patients with breast cancer

et al. 2018

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“…Further declines in heart rate variability after transplantation appear minor, unlike in adults. 10 Heart rate variability decreases with age 22,23 from childhood. 24 Infants have high sympathetic activity that decreases quickly between the ages of 5 and 10 years.…”

Section: Discussionmentioning

confidence: 99%

“…18 An earlier investigation for adults which evaluated haematopoietic stem cell transplantation revealed changes in heart rate variability and heart rate turbulence, both of which were attributed to the transplantation procedure. 10 The use of cyclophosphamide, total body irradiation, and cytokines 19,20 should be considered as well in understanding the complex mechanisms of decreased heart rate variability. Although not investigated in the cohort, mental stress associated with treatment and diminished exercise tolerance due to long-term hospitalisation might also have affected autonomic nervous function.…”

Section: Discussionmentioning

confidence: 99%

“…[4][5][6][7][8][9] In adult patients with haematological malignancies, decreased heart rate variability was observed after chemotherapy and haematopoietic stem cell transplantation, indicating that heart rate variability monitoring could serve in predicting cardiac complications associated with chemotherapy. 10,11 Although several reports have described decreased autonomic nervous function after chemotherapy in paediatric leukaemia patients, none have addressed the changes in heart rate variability before and after haematopoietic stem cell transplantation.…”

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confidence: 99%

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Heart rate variability in the course of chemotherapy and haematopoietic stem cell transplantation for peadiatric patients with haematological malignancies

et al. 2020

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AbstractBackground:High-dose chemotherapy and haematopoietic stem cell transplantation are essential for patients with paediatric haematologic diseases, although cardiotoxicity remains a concern. Heart rate variability analysis can evaluate autonomic nervous function interactions with cardiac function.Objective:This study aimed to characterise heart rate variability differences between patients undergoing chemotherapy and controls, and the effects of haematopoietic stem cell transplantation on the autonomic nervous system in patients with haematological malignancies.Methods:Nineteen patients (11 male, median age: 11.6 years) who received conventional chemotherapy followed by transplantation and 19 non-transplant patients (10 male, median age: 11.5 years) receiving chemotherapy only between 2006 and 2018 for haematological malignancies were retrospectively enrolled. Data from 24-hour Holter monitoring were recorded after chemotherapy and before and after transplantation. Heart rate variability was analysed in patients and 32 matched normal controls.Results:There were significant differences between patients and normal controls in all heart rate variability analysis parameters apart from coefficient of variation of RR interval and standard deviation of the average normal RR interval for all 5-minute segments during sleeping. There was a significant difference in the cumulative anthracycline dose and heart rate variability during sleep between the non-transplant and pre-transplant groups. We observed no remarkable differences in time-domain analysis parameters between before and after transplantation, although the low-frequency component of power-spectrum analysis during awake hours was significantly decreased after transplantation.Conclusion:Conventional chemotherapy for paediatric haematologic diseases may be a risk factor for autonomic dysfunction. Further declines in heart rate variability after transplantation appear minor.

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“…Until now, the detailed range of possible cardiovascular complications and potential cardiotoxic effects of the stem cell administration in individual groups of patients remains unknown. Our previous studies showed that in patients with hematopoietic malignancies undergoing HSCT, after chemotherapy and stem cell administration, the decreased heart rate variability and heart rate turbulence were observed [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Endothelial Function in Patients with Hematologic Malignancies Undergoing High-Dose Chemotherapy Followed by Hematopoietic Stem Cell Transplantation

et al. 2015

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The aim of the study was to examine endothelial function in patients with hematological malignancies treated with high-dose chemotherapy followed by hematopoietic stem cell transplantation. The studies were conducted on 43 consecutive patients qualified for HSCT following high-dose chemotherapy based on the current standards. Then, due to exclusion criteria, a group of 38 patients were chosen for further investigations. Evaluation of endothelial function by means of flow-mediated dilatation (FMD) was conducted in patients with hematological malignancies before HSCT (test A) and after HSCT (test B). Brachial artery diameter (BAD) after occlusion, change in BAD and FMD were significantly lower after HSCT as compared to the results obtained before the transplantation (p < 0.05). The regression analysis indicated that administration of fludarabine and cytarabine, and also higher blood concentrations of creatinine represented risk factors for the impairment of endothelial function expressed as decreased FMD value. In patients with hematopoietic malignancies treated with HSCT, endothelial function assessed by the flow-mediated dilatation was impaired after chemotherapy and stem cell administration.

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Heart Rate Variability and Heart Rate Turbulence in Patients with Hematologic Malignancies Subjected to High‐Dose Chemotherapy in the Course of Hematopoietic Stem Cell Transplantation

Abstract: In patients with hematopoietic malignancies treated with HSCT, decreased HRV and HRT were observed after chemotherapy and stem cells administration.

Cited by 17 publications

References 26 publications

Heart rate variability during and after chemotherapy with anthracycline in patients with breast cancer

Heart rate variability during and after chemotherapy with anthracycline in patients with breast cancer

Heart rate variability in the course of chemotherapy and haematopoietic stem cell transplantation for peadiatric patients with haematological malignancies

Endothelial Function in Patients with Hematologic Malignancies Undergoing High-Dose Chemotherapy Followed by Hematopoietic Stem Cell Transplantation

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