Heart rate variability as a biomarker of functional outcomes in persons with acquired brain injury: Systematic review and meta-analysis

Lee, Yejin; Walsh, Ryan; Fong, Mandy W.M.; Sýkora, Marek; Doering, Michelle; Wong, Alex

doi:10.1016/j.neubiorev.2021.10.004

Cited by 13 publications

(12 citation statements)

References 80 publications

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“…In recent years, studies have shown that measurements of HRV can improve clinical outcomes in some patient groups. A systematic review with a meta-analysis has suggested that HRV can be used as a biomarker to assist in accurately monitoring functional outcomes in individuals following acquired brain injury [ 13 ]. There are also associations between HRV and electrodermal activity (EDA) in those with complex neuropsychiatric disorders such as aggression and anti-social spectrum disorders [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

An Observational Study of Heart Rate Variability Using Wearable Sensors Provides a Target for Therapeutic Monitoring of Autonomic Dysregulation in Patients with Rett Syndrome

et al. 2022

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Rett Syndrome (RTT) is a complex neurodevelopmental disorder that has multi-system involvement with co-occurring epilepsy, breathing problems and autonomic dysregulation. Autonomic dysregulation can increase the risk of cardiorespiratory vulnerability in this patient group. Assessment of heart rate variability (HRV) provides an overview of autonomic health in RTT and offers insight into how the sympathetic and parasympathetic components of the nervous system function. However, to our knowledge, no study has evaluated HRV in Rett patients to assess how the dynamics of autonomic function vary with age and changes during the day and/or night. Using non-invasive wearable sensors, we measured HRV in 45 patients with RTT and examined the time and frequency domain sympathetic and parasympathetic indices. Among the HRV indices assessed, heart rate decreases with age and is lower in the night across all ages studied. The sympathetic index (SDNN) and the parasympathetic indices (RMSSD and pNN50) are not seen to change with age. Nevertheless, these indices were all higher during the day when compared to the night. Our findings appear to show that Rett patients are less adaptable to autonomic changes during the night. In the clinical setting, this might be more relevant for patients with severe psychopathology.

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Section: Introductionmentioning

confidence: 99%

An Observational Study of Heart Rate Variability Using Wearable Sensors Provides a Target for Therapeutic Monitoring of Autonomic Dysregulation in Patients with Rett Syndrome

et al. 2022

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“…For this systematic review, traumatic injuries are defined as any physical injuries or trauma such as injuries resulting from: burn, fall, explosion, blast, gunshot, amputation and accidents. Studies reporting traumatic brain injury (TBI), spinal cord injury, haemorrhage and psychological trauma such as PTSD, depression, and anxiety will be excluded [22][23][24][25].…”

Section: Eligibility Criteriamentioning

confidence: 99%

“…This study will include heart rate, type and mechanism of TI and time from TI as the secondary outcomes: There will be no restrictions on date, and geographical area. The inclusion and exclusion criteria are based on previous studies on the topic [3,4,[18][19][20][21][22][23][24][25] and are listed in Table 1.…”

Section: Eligibility Criteriamentioning

confidence: 99%

“…In the last two decades, research into the impact of TI on HRV has been largely focused on acute trauma and during hospital admission [18][19][20][21]. While recent systematic reviews have summarized the relationship between HRV and depression [22], Post Traumatic Stress Disorder (PTSD) [23], and selected TBI [24] and spinal cord injury [25]; the current knowledge gap is in non-acute TI and HRV with the need to include multiple injury types. To date, no such systematic review has been undertaken.…”

Section: Introductionmentioning

confidence: 99%

“…This protocol for systematic review aims to address this research gap by reviewing the existing evidence base relating to generalized non-acute TI (excluding selected TBI, spinal cord, haemorrhage, PTSD and depression) [22][23][24][25] and HRV. This should lead to greater understanding of the longer-term impact of TI on autonomic function and the potential for preventive measures to moderate this pathway.…”

Section: Introductionmentioning

confidence: 99%

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Association between non-acute traumatic injury (TI) and heart rate variability (HRV) in adults: A systematic review protocol

et al. 2022

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Heart Rate Variability (HRV) is an indirect measure of autonomic function. Attenuated HRV is linked to worsening health outcomes including Major Adverse Cardiovascular Events (MACE). The relationship between traumatic injury (TI) and HRV has been limitedly studied. This research protocol has been designed to conduct a systematic review of the existing evidence on the association between non-acute TI and HRV in adults. Four electronic bibliographic databases (Web of Science, CINAHL, Medline, and Scopus) will be searched. The studies on non-acute (>7 days post injury) TI and HRV in adults will be included, followed by title-abstract screening by two reviewers independently. The quality and risk of bias of the included studies will be assessed using Axis and a six-item Risk of Bias Assessment tool for of Non-randomized Studies (RoBANS) respectively. Grading of Recommendations Assessment, Development and Evaluation (GRADE) will assess the quality of evidence. The extracted data will be synthesized using narrative syntheses and a Forest plot with or without meta-analysis- whichever permitted by the pooled data. This will be the first systematic review to examine the relationship between generalized TI and HRV in adults. Trial registration: (PROPSERO registration number: CRD: CRD42021298530) https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021298530.

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The ECG abnormalities in persons with chronic disorders of consciousness

Tan,

Luo,

Xiao

et al. 2024

Med Biol Eng Comput

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Heart rate variability as a biomarker of functional outcomes in persons with acquired brain injury: Systematic review and meta-analysis

Cited by 13 publications

References 80 publications

An Observational Study of Heart Rate Variability Using Wearable Sensors Provides a Target for Therapeutic Monitoring of Autonomic Dysregulation in Patients with Rett Syndrome

An Observational Study of Heart Rate Variability Using Wearable Sensors Provides a Target for Therapeutic Monitoring of Autonomic Dysregulation in Patients with Rett Syndrome

Association between non-acute traumatic injury (TI) and heart rate variability (HRV) in adults: A systematic review protocol

The ECG abnormalities in persons with chronic disorders of consciousness

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