Heart rate variability correlates with the effect of sulforaphane on calorie-induced inflammation in healthy participants: a randomized placebo-controlled study

Steenwijk, Hidde P. van; Osch, Frits van; Troost, Freddy J.; Bast, Aalt; Boer, Alie de; Semen, Khrystyna

doi:10.1016/j.nutos.2023.05.002

Cited by 1 publication

(1 citation statement)

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“…We have conducted a randomized, placebo-controlled, double-blind study with a cross-over design ( 58 , 59 ). The study protocol (NL77272.068.21) was approved by the Medical Ethics Review Committee of Maastricht University Medical Centre+ (MUMC+) and Maastricht University, Maastricht, the Netherlands, and performed in full accordance with the declaration of Helsinki of 1975 as revised in 2013, Fortaleza, Brazil ( 60 ).…”

Section: Methodsmentioning

confidence: 99%

Sulforaphane as a potential modifier of calorie-induced inflammation: a double-blind, placebo-controlled, crossover trial

van Steenwijk,

Vinken,

van Osch

et al. 2023

Front. Nutr.

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Background and aimsObservational data indicate that diets rich in fruits and vegetables have a positive effect on inflammatory status, improve metabolic resilience and may protect against the development of non-communicable diseases. Nevertheless, experimental evidence demonstrating a causal relationship between nutrient intake (especially whole foods) and changes in metabolic health is scarce. This study investigated the pleiotropic effects of sulforaphane from broccoli sprouts, compared to pea sprouts, on biomarkers of endothelial function, inflammation and metabolic stress in healthy participants subjected to a standardized caloric challenge.MethodsIn this double-blind, crossover, randomized, placebo-controlled trial 12 healthy participants were administered 16 g broccoli sprouts, or pea sprouts (placebo) followed by the standardized high-caloric drink PhenFlex given to disturb healthy homeostasis. Levels of inflammatory biomarkers and metabolic parameters were measured in plasma before and 2 h after the caloric overload.ResultsAdministration of broccoli sprouts promoted an increase in levels of CCL-2 induced by caloric load (p = 0.017). Other biomarkers (sICAM-1, sVCAM-1, hs-CRP, and IL-10) individually showed insignificant tendencies toward increase with administration of sulforaphane. Combining all studied biomarkers into the systemic low-grade inflammation score further confirmed upregulation of the inflammatory activity (p = 0.087) after sulforaphane. No significant effects on biomarkers of metabolic stress were detected.ConclusionThis study has demonstrated that sulforaphane facilitated development of a mild pro-inflammatory state during the caloric challenge, which could be suggestive of the onset of the hormetic response induced by this phytonutrient. The use of integrative outcomes measures such as the systemic low-grade inflammation score can be viewed as a more robust approach to study the subtle and pleiotropic effects of phytonutrients.Clinical trial registration:www.clinicaltrials.gov, identifier NCT05146804.

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Section: Methodsmentioning

confidence: 99%