Heart rate variability in patients with psoriatic arthritis: associations with systemic inflammation and traditional cardiovascular risk factors

Abstract

Aim. To identify the disturbances of vegetative heart regulation and their associations with systemic inflammation activity in patients with psoriatic arthritic (PsA). Material and methods. The main group (MG) included 32 PsA patients without cardiovascular disease, CVD (mean age 44,62±11,6 years; mean PsA duration 10,32±10,2 years; 52,3% men). The control group (CG) included 25 healthy volunteers (mean age 40,33±11,8 years; 49,1% men). Time and spectral parameters of heart rate variability (HRV) were assessed. PsA activity was assessed by DAS index, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and fibrinogen (FG) levels. Cardiovascular risk (CVR) was calculated, based on the following parameters: lipid spectr arterial hypertension, body mass index, and family history of CVD. Results. Compared to CG, all HRV parameters were affected in MG patients (p<0,01). HRV parameters were associated with PsA activity (ESR, CRP, FG, enthesitis), as well as with CVD risk factors (dyslipidemia, age). Conclusion. In PsA patients, disturbed vegetative heart regulation was manifested in reduced HRV and activated sympathetic HRV component. These disturbances were associated with traditional CVD risk factors and systemic inflammation activity.

The role of endothelial damage and dyslipidemia in the development of cardiovascular pathology in psoriatic arthritis

“…Наиболее значимой находкой при ЭХО-КГ у больных ПА является аортит [31]. По данным И. З. Гайдуковой (2011 г.…”

“…), дилатация аорты и очаговые уплотнения на ее задней стенке, обнаруживаемые у 36% больных, предположительно ассоциированы с псориатическим спондилитом. Эхокардиографические изменения были выявлены у 21 больного (5,7%) -аортальная недостаточность превалировала над митральной в 6 раз, комбинированный митрально-аортальный порок встречался вдвое чаще изолированных [31]. F. Atzeni и соавт.…”