Heat Shock Protein 70 Acts as a Potential Biomarker for Early Diagnosis of Heart Failure

Abstract

Early identification for heart failure (HF) may be useful for disease modifying treatment in order to reduce heart disease progression or even to reverse it. In our previous studies, we have revealed a group of heat shock proteins (HSPs) which might be related to neonatal rat cardiomyocyte hypertrophy by proteomic approach. Here, we confirm that HSPs, including HSP27 and HSP70, altered in the early stage of cardiac remodeling in vivo animal model. Furthermore, plasma concentrations of those HSPs and their potential screening value were evaluated at different stages in 222 patient subjects. Plasma HSP27, HSP70 and HSP90 were measured using enzyme-linked immunosorbent assay. Results indicate that HSP70 was positively correlated to the severity (progression) of HF (r = 0.456, p<0.001). The area under the rate of change (ROC) curve was 0.601 (p = 0.017) in patients with stage B HF and 0.835 (p<0.001) in those with stage C HF. However, HSP27 and HSP90 did not display significant changes in any stage of HF in this study. Taken together, plasma concentrations of HSP70 elevated with the progression of HF and might act as a potential screening biomarker for early diagnosis of HF.

Class III PI3K‐mediated prolonged activation of autophagy plays a critical role in the transition of cardiac hypertrophy to heart failure

“…The employment of cardiac hypertrophy model induced by Hsp27 in current study was based on the following reasons. ( i ) Hsp27 is dramatically upregulated in cardiac hypertrophy induced by different stimuli such as isoproterenol and human αB‐Crystallin mutation . Also, Hsp27 is upregulated in dilated cardiomyopathy, which is usually resulted from cardiac hypertrophy .…”

The human HSP70 family of chaperones: where do we stand?

“…Hsp70-1 upregulation in the peripheral lung tissues of patients with chronic obstructive pulmonary disease is closely related to disease severity and smoking status (Dong et al 2013). In patients with heart failure, plasma concentrations of Hsp70-1 increased gradually with the progression of disease stages, thereby suggesting that Hsp70-1 could be used as a potential screening biomarker for the early diagnosis of heart failure (Li et al 2013b) and as an independent prognostic marker of mortality (Jenei et al 2013). Of note, Hsp70-2 protein expression in peripheral blood mononuclear cells is significantly lower in multiple sclerosis (MS) patients with GG genotype compared to AA genotype, thereby indicating an implication of the G allele of HSPA1B polymorphism in the development of MS (Boiocchi et al 2014).…”

Proteomic Biomarkers of Heart Failure

“…In addition to their mechanistic interactions, S100A8/9 have also been shown to provide predictive qualities for mortality in elder patients with severe HF (153). Similarly, circulating heat shock protein 70 (HSP70) has been shown to rise in concurrence with cardiac expression (154) and HF severity (HF) (155), and has been implicated as a potential biomarker for early diagnosis of HF (155).…”