Heat shock protein induction in rat hearts. A role for improved myocardial salvage after ischemia and reperfusion?

Abstract

In this model of ischemia and reperfusion, prior heat shock was associated with significantly improved myocardial salvage after 35 minutes of LCA occlusion and reperfusion. This improved salvage was correlated with marked HSP72 induction and was independent of the hemodynamic determinants of myocardial oxygen supply and myocardial oxygen demand during the ischemic period. In contrast, mild HSP72 induction by ischemic pretreatment was not associated with improved myocardial salvage after myocardial ischemia and reperfusion. Thus, the absolute levels of HSP72 may be important in conferring protection from ischemic injury in this animal model.

Hyperthermia-induced HSP expression correlates with improved rat renal isograft viability and survival in kidneys harvested from non-heart-beating donors

“…In good agreement with earlier studies, we found strongly induced expression of renal HSP72 expression following hyperthermia preconditioning [9,11,34,351. So far HSP72 has been implicated with protection of graft survival in several studies 12,17,34,351.…”

Rescuing of deficient killing and phagocytic activities of macrophages derived from non-obese diabetic mice by treatment with geldanamycin or heat shock: potential clinical implications

“…Thus, hspmediated immune activation may constitute a primary signal to activate and control the inflammatory process resulting in faster destruction of pathogens, clearance of necrotic and apoptotic cells (AC), activation of healing mechanisms, and homeostasis restoration. In agreement with this, induction of hsp in several clinical conditions, such as ischemia/reperfusion, infections, respiratory distress, hemorrhage, and diabetes, has been observed (Donnelly et al 1992;De Maio 1999;Giffard et al 2008;Villar et al 1993). Among these conditions, diabetes and, more specifically, diabetes mellitus type 1 (DMT1) represents an interesting scenario for a potential modulatory effect of hsp, particularly since functional and developmental defects of professional phagocytes have been associated with the initiation and progression of this autoimmune disease (Bagley et al 2008;Hutchings et al 1990;Jun et al 1999;Maree et al 2005;Gordon and Taylor 2005).…”

Activation of ɛ protein kinase C correlates with a cardioprotective effect of regular ethanol consumption

“…Potential mediators of ischemic preconditioning's first window of protection (up to 3 hr) include PKC activation of ATP-sensitive potassium channels causing reduced calcium influx (31,(51)(52)(53) and activation of vacuolar proton ATPase reducing intracellular acidification (54). Potential mediators of ischemic preconditioning's second window of protection (24-72 hr) include transcription factors activated via a PKC-mediated pathway which regulate expression of heat shock/stress proteins (55,56).…”