Heat Shock Proteins and Breast Cancer

Zhang, Miao; Bi, Xiaowen

doi:10.3390/ijms25020876

Cited by 6 publications

(2 citation statements)

References 113 publications

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“…HSPs are critical in modulating the cellular response to ferroptosis, serving as a network of molecular chaperones that assist in the preservation of cellular integrity under oxidative stress. HSPs form an evolutionarily conserved family of molecular chaperones that fulfil a variety of immunological functions ( 66 ). These functions include mitigating cellular stress, exhibiting antioxidant activity, modulating immune responses, and facilitating antigen presentation.…”

Section: Characteristics Of Ferroptosismentioning

confidence: 99%

Ferroptosis: a novel mechanism of cell death in ophthalmic conditions

Yang,

Lin,

Han

et al. 2024

Front. Immunol.

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Ferroptosis, a new type of programmed cell death proposed in recent years, is characterized mainly by reactive oxygen species and iron-mediated lipid peroxidation and differs from programmed cell death, such as apoptosis, necrosis, and autophagy. Ferroptosis is associated with a variety of physiological and pathophysiological processes. Recent studies have shown that ferroptosis can aggravate or reduce the occurrence and development of diseases by targeting metabolic pathways and signaling pathways in tumors, ischemic organ damage, and other degenerative diseases related to lipid peroxidation. Increasing evidence suggests that ferroptosis is closely linked to the onset and progression of various ophthalmic conditions, including corneal injury, glaucoma, age-related macular degeneration, diabetic retinopathy, retinal detachment, and retinoblastoma. Our review of the current research on ferroptosis in ophthalmic diseases reveals significant advancements in our understanding of the pathogenesis, aetiology, and treatment of these conditions.

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Section: Characteristics Of Ferroptosismentioning

confidence: 99%

Ferroptosis: a novel mechanism of cell death in ophthalmic conditions

Yang,

Lin,

Han

et al. 2024

Front. Immunol.

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“…From a molecular point of view, breast cancer has been found to be associated with the overexpression of HSP90 [13], a chaperone that interacts with various proteins that promote the development of breast cancer. HSP90 interacts with the estrogen receptor (ER) antiapoptotic kinase Akt, tumor suppressor p53 protein, Raf-1 MAP kinase, angiogenesis transcription factor HIF-1alpha, and receptor tyrosine kinases from the erbB family [14,15]. Consequently, it makes sense to consider the HSP90 pathway in breast cancer therapy [16].…”

Section: Introductionmentioning

confidence: 99%

Plant-Based HSP90 Inhibitors in Breast Cancer Models: A Systematic Review

Zarguan,

Ghoul,

Belayachi

et al. 2024

IJMS

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Breast cancer, the most invasive cancer in women globally, necessitates novel treatments due to prevailing limitations of therapeutics. Search of news anticancer targets is more necessary than ever to tackle this pathology. Heat-Shock Protein 90 (HSP90), a chaperone protein, is implicated in breast cancer pathogenesis, rendering it an appealing target. Looking for alternative approach such as Plant-based compounds and natural HSP90 inhibitors offer promising prospects for innovative therapeutic strategies. This study aims to identify plant-based compounds with anticancer effects on breast cancer models and elucidate their mechanism of action in inhibiting the HSP90 protein. A systematic review was conducted and completed in January 2024 and included in vitro, in vivo, and in silico studies that investigated the effectiveness of plant-based HSP90 inhibitors tested on breast cancer models. Eleven studies were included in the review. Six plants and 24 compounds from six different classes were identified and proved to be effective against HSP90 in breast cancer models. The studied plant extracts showed a dose- and time-dependent decrease in cell viability. Variable IC50 values showed antiproliferative effects, with the plant Tubocapsicum anomalum demonstrating the lowest value. Withanolides was the most studied class. Fennel, Trianthema portulacastrum, and Spatholobus suberectus extracts were shown to inhibit tumor growth and angiogenesis and modulate HSP90 expression as well as its cochaperone interactions in breast cancer mouse models. The identified plant extracts and compounds were proven effective against HSP90 in breast cancer models, and this inhibition showed promising effects on breast cancer biology. Collectively, these results urge the need of further studies to better understand the mechanism of action of HSP90 inhibitors using comparable methods for preclinical observations.

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Nanomaterials for Endogenous and Exogenous Hydrogen Sulfide-Based NIR Photothermal Cancer Therapy: A Review

Zeng,

Wu,

Pan

et al. 2024

ACS Appl. Nano Mater.

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Hydrogen sulfide (H 2 S) is recognized as the third gaseous signaling molecule present, playing a crucial role in cellular processes. When designing nanomaterials, H 2 S not only serves as a cancer biomarker but also directly influences tumor cell proliferation and metastasis by modulating its concentration. However, gas donor inability to actively accumulate within tumors and release gas in a controlled manner results in restricted cancer treatment efficacy and potential toxic side effects. Near-infrared (NIR) responsive photothermal probes are characterized by their rapid response time, high selectivity, sensitivity, and noninvasive attributes. They offer the opportunity for precise, real-time, and controlled modulation of H 2 S concentrations at both cellular and murine levels. The integration of photothermal therapy with gas therapy and other treatment modalities through multifunctional nanocarrier platforms shows promise in enhancing cancer treatment outcomes while minimizing adverse effects. The development of multifunctional probes capable of controllably modulating H 2 S concentrations and photothermal properties is considered essential yet challenging in academic research. This Review critically assesses two primary approaches in tumor NIR photothermal strategies involving H 2 S: multifunctional photothermal probes targeted utilizing H 2 S as a biomarker and probes combining H 2 S gas therapy with photothermal and alternative modalities. Additionally, this Review addresses the current limitations of these technologies and outlines potential future directions for advancement. Overall, this Review aims to provide insights and guidance for the seamless integration of H 2 S and photothermal probes in cancer therapy, aligning with the rigorous standards of academic journals.

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Heat Shock Proteins and Breast Cancer

Cited by 6 publications

References 113 publications

Ferroptosis: a novel mechanism of cell death in ophthalmic conditions

Ferroptosis: a novel mechanism of cell death in ophthalmic conditions

Plant-Based HSP90 Inhibitors in Breast Cancer Models: A Systematic Review

Nanomaterials for Endogenous and Exogenous Hydrogen Sulfide-Based NIR Photothermal Cancer Therapy: A Review

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