Heat Transfer in Homogeneous Systems

Kinetics analysis and automated online screening of aminocarbonylation of aryl halides in flow

“…The use of microreactors in gas-liquid reactions enables facile control over the temperature, pressure, and reaction time. 19 The small size of the reactor permits high temperatures and pressures to be routinely applied, 20,21 enabling a safe work environment and an expanded reaction space with high reproducibility. 22 For initial studies, samples were automatically collected for offline analysis and reaction conditions were adjusted, including temperature and reaction time, using a Labview-driven reaction system similar to systems we have recently reported.…”

Pressure‐Accelerated Azide–Alkyne Cycloaddition: Micro Capillary versus Autoclave Reactor Performance

“…To the best of our knowledge industrially used high pressure reactors have a range of 5–2000 bar and require special precautions, advanced safety control installation, regular check of tightened areas for leaks, and constant monitoring during the operation. In microflow, high pressure applications fall into a much narrower space of only 5–600 bar 7e. 9 A few hundred bars can be applied and sustained within a microflow reactor of any desired volume by using HPLC pumps equipped with an appropriate back‐pressure regulator.…”