Heavy Metal Exposure and Cardiovascular Disease

Pan, Ziwei; Gong, Tingyu; Liang, Ping

doi:10.1161/circresaha.123.323617

Cited by 22 publications

(2 citation statements)

References 201 publications

(305 reference statements)

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“…The results showed that exogenous harmful substance exposure was a risk factor for COPD and the co-morbidity of COPD and hypertension, but the association between hypertension alone was not statistically significant. Previous studies have shown an association between heavy metal exposure and hypertension development ( 14 ), but essentially no studies have reported an association between exposures to substances such as inorganic mineral dust and agricultural and livestock by-products and hypertension. The results demonstrate that exposure to exogenous harmful substances contributes to the development of COPD and that the exposure increases the risk of hypertension co-morbidity in those who already have COPD.…”

Section: Discussionmentioning

confidence: 99%

“…A study based on NHANES data found that co-exposure to polycyclic aromatic hydrocarbons (PAHs) was associated with COPD (OR = 1.44, 95% CI: 1.09–1.90) ( 13 ). Meanwhile, epidemiological and clinical studies have shown that heavy metals can promote the production of reactive oxygen species and induce inflammation, leading to an increased risk of hypertension, cardiac arrhythmias, and atherosclerosis ( 14 ). The effects of exogenous harmful substance exposure were diverse and complex ( 15 ), with many populations found to have been exposed to exogenous harmful substances from industries such as the chemical or smelting, textile, and animal husbandry ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

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An analysis of exogenous harmful substance exposure as risk factors for COPD and hypertension co-morbidity using PSM

Chen,

Zhou,

Tang

et al. 2024

Front. Public Health

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BackgroundSome occupational and environmental exposures could increase the risk of chronic obstructive pulmonary disease (COPD) and hypertension in various work and living environments. However, the effect of exposure to multiple exogenous harmful substances on COPD and hypertension co-morbidities remains unclear.MethodsParticipants were selected from eight hospitals in five provinces in China using a multistage cluster sampling procedure. Participants' demographic, exposure, and disease information were collected through questionnaires, spirometry, and blood pressure examinations. Demographic data were used as matching factors, and 1:1 matching between the exposed and non-exposed groups was performed by employing propensity score matching (PSM) to minimize the influence on the results. A one-way chi-squared analysis and multifactorial logistic regression were used to analyze the association between the exposure to exogenous harmful substances (metals and their compound dust, inorganic mineral dust, organic chemicals, and livestock by-products) and the co-morbidity of COPD and hypertension.ResultsThere were 6,610 eligible participants in the final analysis, of whom 2,045 (30.9%) were exposed to exogenous harmful substances. The prevalence of co-morbidities of COPD and hypertension (6.0%) in the exposure group was higher than their prevalence in the total population (4.6%). After PSM, exogenous harmful substance exposure was found to be a risk factor for the co-morbidity of COPD and hypertension [odds ratio (OR) = 1.347, 95% confidence interval (CI): 1.011–1.794], which was not statistically significant before PSM (OR = 1.094, 95% CI: 0.852–1.405). Meanwhile, the results of different outcomes showed that the association between hypertension and exogenous harmful substance exposure was not statistically significant (OR = 0.965, 95% CI: 0.846–1.101). Smoking (OR = 4.702, 95% CI: 3.321–6.656), history of a respiratory disease during childhood (OR = 2.830, 95% CI: 1.600–5.006), and history of respiratory symptoms (OR = 1.897, 95% CI: 1.331–2.704) were also identified as risk factors for the co-morbidity of COPD and hypertension.ConclusionThe distribution of exogenous harmful substance exposure varies in the population, and the prevalence of co-morbidities is generally higher in susceptible populations. Exposure to exogenous harmful substances was found to be a key risk factor after adjusting for demographic confounders.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An analysis of exogenous harmful substance exposure as risk factors for COPD and hypertension co-morbidity using PSM

Chen,

Zhou,

Tang

et al. 2024

Front. Public Health

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Are Hair Scalp Trace Elements Correlated with Atherosclerosis Location in Coronary Artery Disease?

Urbanowicz,

Hanć,

Frąckowiak

et al. 2024

Biol Trace Elem Res

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Coronary artery disease is among the leading current epidemiological challenges. The genetic, clinical, and lifestyle-related risk factors are well documented. The reason for specific epicardial artery locations remains unsolved. The coronary artery topography and blood flow characteristics may induce local inflammatory activation. The atherosclerotic plaque formation is believed to represent inflammatory response involving enzymatic processes co-factored by trace elements. The possible relation between trace elements and coronary artery disease location was the subject of the study. There were 175 patients (107 (61) men and 68 (39) females) in a median (Q1-3) age of 71 years (65–76) admitted for coronary angiography due to chronic coronary syndrome. The angiographic results focused on the percentage of lumen stenosis in certain arteries and were compared with the results for hair scalp trace elements. The correlation between left main coronary artery atherosclerotic plaques and nickel (Ni), zinc (Zn), and antimony (Sb) hair scalp concentration was noted. The analysis revealed a positive relation between left descending artery disease and chromium (Cr), sodium (Na), arsenic (As), and molybdenum (Mo) and a negative correlation with strontium (Sr). The atherosclerotic lesion in the circumflex artery revealed correlations in our analysis with sodium (Na), potassium (K), chromium (Cr), nickel (Ni), arsenic (As), and negative with strontium (Sr) (r) hair scalp concentrations. The negative correlations between right coronary artery disease and magnesium (Mg) and strontium (Sr) concentrations were noted. The possible explanation of different epicardial artery involvement and severity by atherosclerotic processes may lay in their topography and blood rheological characteristics that induce different inflammatory reactions co0factored by specific trace elements. The trace element concentration in the hair scalp may correlate with a particular coronary atherosclerotic involvement, including the severity of lumen reduction. This may indicate the missing link between the pathophysiological processes of atherosclerosis development and its location in coronary arteries.

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Nanomaterial-mediated self-calibrating biosensors for ultra-precise detection of food hazards: Recent advances and new horizons

Cao,

Ye,

Ren

et al. 2025

Coordination Chemistry Reviews

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Heavy Metal Exposure and Cardiovascular Disease

Cited by 22 publications

References 201 publications

An analysis of exogenous harmful substance exposure as risk factors for COPD and hypertension co-morbidity using PSM

An analysis of exogenous harmful substance exposure as risk factors for COPD and hypertension co-morbidity using PSM

Are Hair Scalp Trace Elements Correlated with Atherosclerosis Location in Coronary Artery Disease?

Nanomaterial-mediated self-calibrating biosensors for ultra-precise detection of food hazards: Recent advances and new horizons

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