Hedgehog Signaling

Choy, Siu Wah; Cheng, Shuk Han

doi:10.1016/b978-0-12-394622-5.00001-8

Cited by 58 publications

(42 citation statements)

References 105 publications

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“…Here, only Gli repressor forms are able to enter the nucleus. Binding of Hh ligands to the Ptch protein shuttles Ptch out of the cilium, resulting in the release and activation of Smo; then the Gli protein can translocate the nucleus and function as a transcriptional activator (Gill and Rosenblum, 2006;Varjosalo and Taipale, 2008;Choy and Cheng, 2012) (Fig. 1).…”

Section: Hh Signaling Pathwaymentioning

confidence: 99%

An Overview of Hedgehog Signaling in Fibrosis

Lin

et al. 2014

Mol Pharmacol

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The Hedgehog (Hh) signaling pathway plays a key role during embryogenesis and tissue regeneration. Recently, studies revealed that overactivated Hh signaling leads to fibrogenesis in many types of tissues. The activation of Hh signaling is involved in the epithelialmesenchymal transition and excessive extracellular matrix deposition. Blockade of Hh signaling abolishes the induction of the epithelial-mesenchymal transition and ameliorates tissue fibrosis. Therefore, new therapeutic targets to alleviate fibrosis based on the Hh signaling have attracted a great deal of attention. This is a new strategy for treating fibrosis and other related diseases. In this review, we discuss the crucial role of Hh signaling in fibrogenesis to provide a better understanding of their relationship and to encourage the study of novel targeted therapies.

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Section: Hh Signaling Pathwaymentioning

confidence: 99%

An Overview of Hedgehog Signaling in Fibrosis

Lin

et al. 2014

Mol Pharmacol

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“…Gli-1 is a constitutive activator, but Gli-2 and Gli-3 have a C-terminal transcriptional activator domain and an N-terminal transcriptional repressor domain. Shh signaling is required for patterning of the central nervous system, the maintenance, proliferation, and specialization of neural progenitor cells (NPCs)/NSCs, and axonal growth and guidance in the embryonic and adult brain [16,17]. After stroke , the activated Shh signaling pathway is involved in enhancing NPCs proliferation in the subventricular zone, promoting neurogenesis, oligodendrogenesis, and axonal remodeling in the peri-infarct area, and improvement of functional recovery in rats [18].…”

Section: Introductionmentioning

confidence: 99%

Sonic Hedgehog Signaling Mediates Resveratrol to Increase Proliferation of Neural Stem Cells After Oxygen-Glucose Deprivation/Reoxygenation Injury in Vitro

Cheng

Yu²,

Wang³

et al. 2015

Cell Physiol Biochem

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Background/Aims: There is interest in drugs and rehabilitation methods to enhance neurogenesis and improve neurological function after brain injury or degeneration. Resveratrol may enhance hippocampal neurogenesis and improve hippocampal atrophy in chronic fatigue mice and prenatally stressed rats. However, its effect and mechanism of neurogenesis after stroke is less well understood. Sonic hedgehog (Shh) signaling is crucial for neurogenesis in the embryonic and adult brain, but relatively little is known about the role of Shh signaling in resveratrol-enhanced neurogenesis after stroke. Methods: Neural stem cells (NSCs) before oxygen-glucose deprivation/reoxygenation (OGD/R) in vitro were pretreated with resveratrol with or without cyclopamine. Survival and proliferation of NSCs was assessed by the CCK8 assay and BrdU immunocytochemical staining. The expressions and activity of signaling proteins and mRNAs were detected by immunocytochemistry, Western blotting, and RT-PCR analysis. Results: Resveratrol significantly increased NSCs survival and proliferation in a concentration-dependent manner after OGD/R injury in vitro. At the same time, the expression of Patched-1, Smoothened (Smo), and Gli-1 proteins and mRNAs was upregulated, and Gli-1 entered the nucleus, which was inhibited by cyclopamine, a Smo inhibitor. Conclusion: Shh signaling mediates resveratrol to increase NSCs proliferation after OGD/R injury in vitro.

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“…A broad pattern of Shh protein secretion has been reported in a range of tissues during normal development and in some cancers during tumorigenesis. 10 For example, epithelial tissues, limb buds, adrenal gland, central nervous system, pancreatic cancer and gastric adenocarcinomas have all been demonstrated to have Shh protein secretion, 10 but not the testis. Whether or not the Shh protein is a marker for and regulator of spermatocytes needs to be confirmed by further research, and the details of the role played by Shh signalling during sperm formation remains unknown.…”

Section: Discussionmentioning

confidence: 99%

“…10 The Shh-dependent synthesis of corticosteroid in the adrenal gland has confirmed the direct interaction between Shh signalling and Sf-1 in adrenal development. 10 In the testis, the levels of steroidogenic enzymes are also controlled by the NR5A1 gene, and thereby affect the production of testosterone and INSL-3 peptide in the testis. 8 A disruption in the synthesis of androgens can lead to cryptorchidism, as indicated by the correlation between cryptorchidism and expression of the AR gene.…”

Section: Introductionmentioning

confidence: 86%

Ectopic expression of Sonic Hedgehog in a cryptorchid man with azoospermia: A case report

et al. 2014

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A 30-year-old man presented with a left undescended testis, right testicular deficiency and azoospermia. Testicular biopsy revealed an absence of spermatocytes and increased numbers of Leydig cells in the undescended testis. Additional comparative analyses were undertaken to explore Sonic Hedgehog (Shh) immunostaining in the testis of juvenile and adult mice, in the testis of the patient with cryptorchidism, and in archival testicular tissue from a patient with obstructive azoospermia and a patient with prostate cancer. Shh immunostaining was demonstrated in spermatocytes in juvenile and adult mouse testis and in the patients with obstructive azoospermia and prostate cancer, suggesting that Shh signalling is involved in normal spermatogenesis. In the patient with cryptorchidism, Shh immunostaining was localized to the Leydig cells, which suggests that Shh might be involved in the abnormal expansion of the Leydig cell population in the testis. These preliminary data on the appearance of Shh protein during normal spermatogenesis might provide the basis for further investigations to clarify the role of Shh signalling in spermatogenesis during normal and pathogenic testis development.

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Hedgehog Signaling

Cited by 58 publications

References 105 publications

An Overview of Hedgehog Signaling in Fibrosis

An Overview of Hedgehog Signaling in Fibrosis

Sonic Hedgehog Signaling Mediates Resveratrol to Increase Proliferation of Neural Stem Cells After Oxygen-Glucose Deprivation/Reoxygenation Injury in Vitro

Ectopic expression of Sonic Hedgehog in a cryptorchid man with azoospermia: A case report

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