Hedyotis diffusa alleviate aflatoxin B1-induced liver injury in ducks by mediating Nrf2 signaling pathway

AFB1 Toxicity in Human Food and Animal Feed Consumption: A Review of Experimental Treatments and Preventive Measures

“…Screened substances demonstrated a time-dependent AFB1 detoxification capability that ranged from 20.17% to 38.13%, with the highest anti-mycotoxin activity reaching 40.81% [65]. The traditional Chinese herbal medicine plant Hedyotis diffusa was tested for AFB1 actions on the liver and proved to decrease hepatic pathological alterations of ALT, AST, ALP, TP, and ALB, and reduce DNA-adduct formation in the liver by mechanisms involving an increase in the expression Nrf2, and heme oxygenase 1 (HO-1) [66]. In another study, three herbal extracts Ixora coccinea (Rubiaceae), Rhinacanthus nasuta (Acanthaceae), and whole plants of Spilanthes ciliata (Asteraceae), were tested on albino Wistar rats.…”

Network pharmacology, bioinformatics, and experimental validation to identify the role of Hedyotis diffusa willd against gastric cancer through the activation of the endoplasmic reticulum stress

“…In traditional Chinese medicine, Hedyotis diffusa Willd (Family Rubiaceae) is commonly known as Bai Hua She Cao (BHSSC) in pinyin. According to contemporary pharmacological research, BHSSC possesses a wide range of pharmacological properties, including anti-inflammatory [ 4 ], hepatoprotective effect [ 5 , 6 ], antiviral efficacy [ 7 ], antioxidant [ 8 ] and neuroprotective [ 9 ], anti-tumor [ 10 ], and other biological activities.…”