Height, Age, and Atopy Are Associated With Fraction of Exhaled Nitric Oxide in a Large Adult General Population Sample

Olin, Anna‐Carin; Rosengren, Annika; Thelle, Dag S.; Lissner, Lauren; Bake, Björn; Torén, Kjell

doi:10.1378/chest.130.5.1319

Cited by 284 publications

(288 citation statements)

References 29 publications

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“…Previous population studies have shown conflicting results about the relationship between eNO and reported asthma [5][6][7][8][9]. In both of the current study populations, the history of asthma was associated with increased eNO levels, independently of specific IgE levels as a marker of atopy.…”

Section: Exhaled Nitric Oxide In Contrasting Population Samples Of Ficontrasting

confidence: 56%

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Exhaled nitric oxide in contrasting population samples of Finnish and Russian Karelia: Table 1—

Malmberg¹,

Laatikainen²,

Hertzen³

et al. 2010

Eur Respir J

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Section: Exhaled Nitric Oxide In Contrasting Population Samples Of Ficontrasting

confidence: 56%

“…eNO is strongly associated with atopy in populationbased studies [5][6][7][8][9]. Also, many other factors, such as sex and anthropometric dimensions, tobacco smoking and acute respiratory infections, have been reported to influence eNO levels.…”

Section: Exhaled Nitric Oxide In Contrasting Population Samples Of Fimentioning

confidence: 98%

Exhaled nitric oxide in contrasting population samples of Finnish and Russian Karelia: Table 1—

Malmberg¹,

Laatikainen²,

Hertzen³

et al. 2010

Eur Respir J

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“…The data from OLIN et al [44], involving a large population of randomly selected adult subjects, indicated a median FeNO value of 16 ppb, although with a wide range (2.4-199 ppb). The authors observed an association of FeNO values with height and age but not with sex.…”

Section: Results Of the Literature Searchmentioning

confidence: 98%

“…Besides the Task Force recommendations [5], the current authors found three studies primarily focused on normal values in healthy adult subjects fulfilling the literature search criteria, which were all published in 2006 (table 5) [44][45][46]. Overall, 2,452 subjects underwent FeNO measurements.…”

Section: Results Of the Literature Searchmentioning

confidence: 99%

“…Ethical Committee approval and informed consent were mandatory in all studies. For FeNO, as for BAL and induced sputum, inclusion and exclusion criteria differed largely, as one study had been conducted on unselected random subjects from the general population [44]. All studies detected FeNO at a flow rate of 50 mL?s -1 , while the studies employed three different NO analysers (table 5).…”

Section: Results Of the Literature Searchmentioning

confidence: 99%

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Bronchoalveolar lavage, sputum and exhaled clinically relevant inflammatory markers: values in healthy adults

et al. 2007

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Bronchoalveolar lavage (BAL), induced sputum and exhaled breath markers (exhaled nitric oxide and exhaled breath condensate) can each provide biological insights into the pathogenesis of respiratory disorders. Some of their biomarkers are also employed in the clinical management of patients with various respiratory diseases. In the clinical context, however, defining normal values and cut-off points is crucial. The aim of the present review is to investigate to what extent the issue of defining normal values in healthy adults has been pursued for the biomarkers with clinical value.The current authors reviewed data from literature that specifically addressed the issue of normal values from healthy adults for the four methodologies.Most studies have been performed for BAL (n59), sputum (n53) and nitric oxide (n53). There are no published studies for breath condensate, none of whose markers yet has clinical value. In healthy adult nonsmokers the cut-off points (mean+2SD) for biomarkers with clinical value were as follows. BAL: 16.7% lymphocytes, 2.3% neutrophils and 1.9% eosinophils; sputum: 7.7610 6 ?mL -1 total cell count and 2.2% eosinophils; nitric oxide: 20.2 ppb. The methodologies differ concerning the quantity and characteristics of available reference data. Studies focusing on obtaining reference values from healthy individuals are still required, more evidently for the new, noninvasive methodologies.

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Occupational risk factors for airway obstruction in a population‐based study in Northern Europe

Murgia

Brisman

Olin

et al. 2021

American J Industrial Med

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Background Airway obstruction is a key feature of asthma and chronic obstructive pulmonary diseases (COPD). Smoking habits and workplace exposures to vapors, gas, dusts, and fumes (VGDF) could cause or exacerbate airway obstruction. The aim of this study is to evaluate the risk of airway obstruction due to smoking and workplace exposure, and their interaction, in a large population‐based study. Methods In this cross‐sectional study, a sample (n = 6153) of the Swedish population aged between 24 and 76 years underwent a questionnaire, clinical examination, blood test, and spirometry to gather information on airway obstruction classified by Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria or American Thoracic Society (ATS)/European Respiratory Society (ERS) criteria, risk factors, and confounders. Occupational exposures to VGDF were rated according to a specific job‐exposure matrix. Adjusted logistic regression models were used to evaluate risk factors for airway obstruction in smokers and nonsmokers. Results In total, 9.8% had airway obstruction by GOLD criteria and 10.3% by ATS/ERS. Smokers with a high likelihood of exposure to VGDF had a higher risk of airway obstruction than those not exposed (odds ratio [OR]: 1.74, 95% confidence interval [CI]: 1.15–2.65 by GOLD; OR: 1.58, 95% CI: 1.06–2.37 by ATS/ERS) especially those >50 years of age. In smokers highly exposed to VGDF, risk estimates were higher than in the whole population, and the interaction between high exposure to VGDF and smoking further increased the risk of airway obstruction. Conclusions This study suggests a possible role for interaction between cigarette smoking and VGDF exposure on the risk of airway obstruction.

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Height, Age, and Atopy Are Associated With Fraction of Exhaled Nitric Oxide in a Large Adult General Population Sample

Cited by 284 publications

References 29 publications

Exhaled nitric oxide in contrasting population samples of Finnish and Russian Karelia: Table 1—

Exhaled nitric oxide in contrasting population samples of Finnish and Russian Karelia: Table 1—

Bronchoalveolar lavage, sputum and exhaled clinically relevant inflammatory markers: values in healthy adults

Occupational risk factors for airway obstruction in a population‐based study in Northern Europe

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