Heightened risk of second primary carcinoma of the head and neck following cervical neoplasia

Dost, Fatima; Ford, Pauline; Farah, Camile S.

doi:10.1002/hed.23417

Cited by 9 publications

(6 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, in most countries, men are more exposed to unhealthy lifestyles and carcinogenic factors such as alcohol, tobacco and diet, which have been associated with the pathogenesis of the disease [1,21]. In general, age groups that were most affected by ODE and OSCC correspond to the 5th and 7th decade, respectively, and coincides with that reported in the literature [22,23]. This difference could be due to the fact that for the development of an OSCC, the action of carcinogens that provoke non-lethal mutations in the DNA for a long period of time is necessary so that the first cell that multiplies autonomously and uncontrolled will originate into the neoplastic mass.…”

Section: Comparing the Immuno-expression Of Endothelial Markers In Nosupporting

confidence: 78%

Comparing the Immuno-Expression of Endothelial Markers in Normal Oral Mucosa, Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma: Relationship between E-Cadherin, Vimentin, CD31, CD117 and Epithelial-Mesenchymal Transition

Alej

Fernández

Marshall

et al. 2017

MOJAP

View full text Add to dashboard Cite

Objective: To evaluate the expression of E-cadherin, Vimentin, CD31, CD117 in Oral Epithelial Dysplasia (OED) and Oral Squamous Cell Carcinoma (OSCC), in comparison with Normal Oral Mucosa (NOM). Material and Methods:Descriptive case study. Histological samples were analyzed by immunohistochemistry against E-cadherin, Vimentin, CD31, CD117. E-cadherin expression was evaluated by extent and intensity, Vimentin was evaluated by intensity and CD31 and C117 quantitatively. Results:The extent of E-cadherin was greater than 75% in all NOM samples, 81% of the OED samples and 47% of the OSCC samples. The intensity of E-cadherin was high in NOM (100%) and in OSCC (36%). Mean CD31 was 21.2 ± 5 in NOM samples, 23.4 ± 5.8 in OED samples and 36.7 ± 10.8 in OSCC samples. Mean CD117 was 7.2 ± 2.5 in NOM samples, 12.8 ± 5.3 in OED samples and 22.7 ± 5.3 in OSCC samples. Conclusion:The molecular marker E-cadherin is significantly more downregulated in dysplastic cells in comparison to NOM cells, while the mesenchymal marker Vimentin is expressed by epithelial cells in samples of NOM, OED and OSCC; questioning their value as prognostic markers. Finally, the quantification of CD31 and CD117 increased significantly in OSCC samples.

show abstract

Section: Comparing the Immuno-expression Of Endothelial Markers In Nosupporting

confidence: 78%

Comparing the Immuno-Expression of Endothelial Markers in Normal Oral Mucosa, Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma: Relationship between E-Cadherin, Vimentin, CD31, CD117 and Epithelial-Mesenchymal Transition

Alej

Fernández

Marshall

et al. 2017

MOJAP

View full text Add to dashboard Cite

show abstract

“…Most Asian studies were conducted in or by single institutes and had limited populations. 4 , 8 , 25 , 30 , 31 A study published in 2012 based on the Taiwan Cancer Registry that enrolled 52,972 patients also found increased SIRs in patients with cervical cancer. 2 However, only the age of patients, registry date, and sites of cancer were analyzed.…”

Section: Discussionmentioning

confidence: 99%

Secondary Primary Malignancy Risk in Patients With Cervical Cancer in Taiwan

Teng

Huon

et al. 2015

Medicine

View full text Add to dashboard Cite

To evaluate the risk of secondary primary malignancy (SPM) in patients with cervical cancer using a nationwide population-based dataset.Patients newly diagnosed with cervical cancer between 1997 and 2011 were identified using Taiwan's National Health Insurance database. Patients with antecedent malignancies were excluded. Standardized incidence ratios (SIRs) for SPM were calculated by comparing with the cancer incidence in the general population. Risk factors for cancer development were analyzed using Cox proportional hazard models.During the 14-year study period (follow-up of 223,062 person-years), 2004 cancers developed in 35,175 patients with cervical cancer. The SIR for all cancers was 1.56 (95% confidence interval, 1.50–1.63, P < 0.001). SIRs for follow-up periods of >10, 5 to 10, 1 to 5, and <1 year were 1.37, 1.51, 1.34, and 2.59, respectively. After the exclusion of SPM occurring within 1 year of cervical cancer diagnosis, SIRs were significantly higher for cancers of the esophagus (2.05), stomach (1.38), colon, rectum, and anus (1.36); lung and mediastinum (2.28), bone and soft tissue (2.23), uterus (3.76), bladder (2.26), and kidneys (1.41). Multivariate analysis showed that age ≥60 was a significant SPM risk factor (hazard ratio [HR] 1.59). Different treatments for cervical cancer, including radiotherapy (HR 1.41) and chemotherapy (HR 1.27), had different impacts on SPM risk. Carboplatin and fluorouracil independently increased SPM risk in cervical cancer patients.Patients with cervical cancer are at increased risk of SPM development. Age ≥60 years, chemotherapy, and radiotherapy are independent risk factors. Carboplatin and fluorouracil also increased SPM risk independently. Close surveillance of patients at high risk should be considered for the early detection of SPMs.

show abstract

“…Studies have reported that tobacco and/or alcohol induced precancerous fields of the upper aerodigestive tract may be amplified by local HPV infection . A recent Australian study concluded that amongst females with a history of cervical cancer, there was a greater risk of developing oral cancer, particularly of the oropharynx, compared to the general female population . Given the implementation of a national HPV vaccination programme, and the anticipated decline in cervical cancer incidence, it is anticipated that the incidence of oropharyngeal cancers will also decrease in the long term.…”

Section: Discussionmentioning

confidence: 99%

Oral cancer in Australia 1982-2008: a growing need for opportunistic screening and prevention

2014

View full text Add to dashboard Cite

Background: Globally, a decline in the incidence of oral cancer has been noted, while the mortality rates have remained relatively stable. The aim of this study was to provide an update on the incidence and mortality of oral cancer in Australia on a national and state level. Methods: Data regarding new cases and deaths associated with cancer of the lip, oral cavity and oropharynx were obtained from the Australian Institute of Health and Welfare for the period 1982-2008. Crude-and age-standardized incidence and mortality rates were calculated for all of Australia and for each state and territory. Results: A total of 60 826 cases of lip, oral cavity and oropharyngeal cancer were diagnosed in Australia. Between 1992 and 2008, a decline in the annual percentage change of age-standardized incidence was noted. The lip, followed by the tongue, continue to represent the most common sites of new oral cancer cases. There was no significant change in the rates of mortality for oral cancer over the time period. Conclusions: These findings show that the oral cancer mortality rate remains high despite a decline in incidence over the past three decades, highlighting a greater need for dental practitioners to undertake preventive strategies and opportunistic screening for patients.

show abstract

Heightened risk of second primary carcinoma of the head and neck following cervical neoplasia

Abstract: This study demonstrates that women with cervical cancer were almost 7 times more likely to develop head and neck cancer compared to the general female population.

Cited by 9 publications

References 22 publications

Comparing the Immuno-Expression of Endothelial Markers in Normal Oral Mucosa, Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma: Relationship between E-Cadherin, Vimentin, CD31, CD117 and Epithelial-Mesenchymal Transition

Comparing the Immuno-Expression of Endothelial Markers in Normal Oral Mucosa, Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma: Relationship between E-Cadherin, Vimentin, CD31, CD117 and Epithelial-Mesenchymal Transition

Secondary Primary Malignancy Risk in Patients With Cervical Cancer in Taiwan

Oral cancer in Australia 1982-2008: a growing need for opportunistic screening and prevention

Contact Info

Product

Resources

About