Helichrysum italicum (Roth) G. Don: Taxonomy, biological activity, biochemical and genetic diversity

Ninčević, Tonka; Grdiša, Martina; Šatović, Zlatko; Jug-Dujaković, Marija

doi:10.1016/j.indcrop.2019.111487

Cited by 37 publications

(56 citation statements)

References 79 publications

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“…While HA can be found mainly in Poland, Russia, Lithuania, and Latvia [ 3 ], in the Mediterranean region of Slovenia and in other regions with similar climatic conditions, such as coastal Croatia, Italy, Spain, Portugal, and Corsica, Helichrysum italicum (Roth) G. Don (abbreviated as HI) is more common, both as a wild and as a cultivated plant [ 4 ]. Similar to HA, HI is widely used in traditional medicine but has not yet been recognized and evaluated by the HMPC.…”

Section: Introductionmentioning

confidence: 99%

A Comparative Study of the Antioxidative Effects of Helichrysum italicum and Helichrysum arenarium Infusions

et al. 2021

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Helichrysum arenarium (L.) Moench (abbrev. as HA) has a long tradition in European ethnomedicine and its inflorescences are approved as a herbal medicinal product. In the Mediterranean part of Europe, Helichrysum italicum (Roth) G. Don (abbrev. as HI) is more common. Since infusions from both plants are traditionally used, we aimed to compare their antioxidative potential using in vitro assays. Two morphologically distinct HI plants, HIa and HIb, were compared to a commercially available HA product. Genetic analysis using microsatellites confirmed a clear differentiation between HI and HA and suggested that HIb was a hybrid resulting from spontaneous hybridization from unknown HI subspecies. High-performance liquid chromatography–mass spectrometry analysis showed the highest amounts of hydroxycinnamic acids and total arzanol derivatives in HIa, whereas HIb was richest in monohydroxybenzoic acids, caffeic acids, and coumarins, and HA contained the highest amounts of flavonoids, especially flavanones. HIa exhibited the highest radical scavenging activity; it was more efficient in protecting different cell lines from induced oxidative stress and in inducing oxidative stress-related genes superoxide dismutase 1, catalase, and glutathione reductase 1. The antioxidative potential of HI was not only dependent on the morphological type of the plant but also on the harvest date, revealing important information for obtaining the best possible product. Considering the superior properties of HI compared to HA, the evaluation of HI as a medicinal plant could be recommended.

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Section: Introductionmentioning

confidence: 99%

A Comparative Study of the Antioxidative Effects of Helichrysum italicum and Helichrysum arenarium Infusions

et al. 2021

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“…However, their correct taxonomic assignment and clear differentiation are sometimes difficult due to their phenotypic plasticity and existence of intermediates generated with spontaneous hybridization in areas where the subspecies overlap [ 1 , 2 ]. The plant naturally thrives in dry, sandy areas but is also extensively cultivated in several Mediterranean countries due to the high demand for its essential oil by the perfume and cosmetic industry [ 3 ]. Namely, its yellow fade-resistant inflorescences are a treasury of bioactive secondary metabolites that result from the plants adaptation to this challenging environment.…”

Section: Introductionmentioning

confidence: 99%

HPLC-DAD-ESI-QTOF-MS Determination of Bioactive Compounds and Antioxidant Activity Comparison of the Hydroalcoholic and Water Extracts from Two Helichrysum italicum Species

et al. 2020

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Mediterranean plant Helichrysum italicum represents a rich source of versatile bioactive compounds with potential benefits for human health. Despite extensive research on the plant’s active constituents, little attention has yet been paid to characterizing the relationship between its intra-specific genetic diversity and metabolite profile. The study aimed to determine metabolic profile of H. italicum ssp. italicum (HII) and ssp. tyrrhenicum (HIT) cultivated on the experimental plantation in Slovenia and to compare the chemical composition of extracts regarding the solvent extraction process. Extracts were prepared upon conventional extract preparation procedures: maceration with 50% methanol or ethanol and cold or hot water infusion and analyzed using High Performance Liquid Chromatography-Diode Array Detection-Electrospray Ionization-Quadrupole Time-of-Flight-Mass Spectrometry (HPLC-DAD-ESI-QTOF-MS). One hundred compounds were identified in the samples, among them several isomers and derivatives were reported for the first time, while caffeoylquinic acids and pyrones were the most abundant. Semi-quantitative comparison revealed that the extraction procedure had a greater impact on the chemical profile than genetic variability. All HIT extracts showed a higher total phenolic content compared to HII, while the antioxidant potential evaluated by 1,1-diphenyl-2-picrylhydrazil test was not proportionally higher. In addition, hot water extracts proved to be comparably active as alcoholic ones, confirming high commercial potential of Helichrysum italicum as herbal functional beverages.

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“…The Helichrysum Miller genus includes more than a thousand of taxa, among them the most well-known and studied species are Helichrysum italicum (Roth) G. Don [ 7 ] ( Figure 1 ), Helichrysum stoechas (L.) Moench [ 8 ], and Helichrysum arenarium (L.) Moench [ 9 ]. H. italicum and H. stoechas are distributed throughout the Mediterranean [ 10 ] but are especially characteristic to Adriatic region [ 11 ] and Iberian Peninsula [ 12 ], respectively, whereas H. arenarium is mostly found in the Central Europe [ 9 , 10 ]. Despite the long tradition in treatment of various disorders for all three before-mentioned species, their traditional use for treating digestive problems (e.g., fullness and bloating) has been approved by the WHO and the European Medicines Agency (EMA) for the species H. arenarium alone [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…Among the H. italicum species, there are also several subspecies (abbreviated ssp. ), which are difficult to distinguish due to a strong polymorphism in morphology [ 10 ]. The explanation of H. italicum classification is beyond the scope of this review article, but the name of subspecies is included, if available in the referenced article.…”

Section: Introductionmentioning

confidence: 99%

A Review and Evaluation of the Data Supporting Internal Use of Helichrysum italicum

Kramberger

Kenig

Pražnikar

et al. 2021

Plants

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Helichrysum italicum is a Mediterranean plant with various pharmacological activities. Despite extensive reports on the bioactivity of the plant, its clinically studied applications have not yet been reviewed. The aim of our study was to gather information on the internal use of H. italicum and its bioactive constituents to determine its efficacy and safety for human use. We reviewed research articles that have not been previously presented in this context and analyzed relevant clinical studies with H. italicum. Cochranelibrary.com revealed six eligible clinical trials with H. italicum that examined indications for pain management, cough, and mental exhaustion. Although the efficacy of H. italicum has been demonstrated both in in vitro tests and in humans, it is difficult to attribute results from clinical trials to H. italicum alone, as it has usually not been tested as the sole component. On the other hand, clinical trials provide positive information on the safety profile since no adverse effects have been reported. We conclude that H. italicum is safe to use internally, while new clinical studies with H. italicum as a single component are needed to prove its efficacy. Based on the recent trend in H. italicum research, further studies are to be expected.

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Helichrysum italicum (Roth) G. Don: Taxonomy, biological activity, biochemical and genetic diversity

Cited by 37 publications

References 79 publications

A Comparative Study of the Antioxidative Effects of Helichrysum italicum and Helichrysum arenarium Infusions

A Comparative Study of the Antioxidative Effects of Helichrysum italicum and Helichrysum arenarium Infusions

HPLC-DAD-ESI-QTOF-MS Determination of Bioactive Compounds and Antioxidant Activity Comparison of the Hydroalcoholic and Water Extracts from Two Helichrysum italicum Species

A Review and Evaluation of the Data Supporting Internal Use of Helichrysum italicum

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