Helichrysum plicatum DC. subsp. plicatum extract as a preventive agent in experimentally induced urolithiasis model

Bayır, Yasin; Halıcı, Zekai; Keleş, Mevlüt Sait; Çolak, Suat; Çakır, Ahmet; Kaya, Yusuf; Akçay, Fatih

doi:10.1016/j.jep.2011.09.026

Cited by 31 publications

(12 citation statements)

References 28 publications

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“…The treatment of this disease includes medical and surgical treatment. However, surgical removal of stones by lithotripsy and percutaneous nephrolithotomy techniques can cause several side effects such as tubular necrosis, fibrosis of the kidney, and renal stone formation [2]. Medicinal plant materials could be beneficial to find out efficient cure for urinary stones [3].…”

Section: Introductionmentioning

confidence: 99%

Preclinical Evaluation of Antiurolithiatic Activity of Viburnum opulus L. on Sodium Oxalate‐Induced Urolithiasis Rat Model

İlhan

Ergene

Süntar

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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The aim of the present research is to evaluate the antiurolithiatic effect of the various extracts prepared from the fruits of Viburnum opulus L., in regard to its ethnobotanical record. To induce urolithiasis, 70 mg/kg sodium oxalate was injected to the rats which were housed individually in metabolic cages. The test materials were applied during 7 days. Biochemical (urine and serum parameters), histopathological and antioxidant (TBARs, TSH and GSH) assays were conducted. The urine samples were examined by light microscope for the determination of the calcium oxalate crystals. Lyophilized juice of V. opulus (LJVO) and lyophilized commercial juice of V. opulus (LCJVO) exerted potential antiurolithiatic activity which was attributed to its diuretic effect along with the inhibitory action on the oxalate levels and free radical production. We also determined the chlorogenic acid content of the LJVO by high-performance liquid chromatography (HPLC). Chlorogenic acid was determined by using Supelcosil LC-18 (250 × 4.6 mm, 5 µm) column and acetonitrile: water: 0.2% o-phosphoric acid as a mobile phase. The chlorogenic acid content of V. opulus was found to be 0.3227 mg/mL in fruit juice. The results obtained in this study have provided a scientific evidence for the traditional usage of V. opulus on passing kidney stones in Turkish folk medicine.

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Section: Introductionmentioning

confidence: 99%

Preclinical Evaluation of Antiurolithiatic Activity of Viburnum opulus L. on Sodium Oxalate‐Induced Urolithiasis Rat Model

İlhan

Ergene

Süntar

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…In this study, Bayır et al (2011) have investigated the preventive effect of Helichrysum plicatum ssp. plicatum (HP) at 125, 250 and 500 mg/kg doses in 1% ethylene glycol and 1% ammonium chloride-induced urolithiasis model in rats.…”

Section: Discussionmentioning

confidence: 99%

Preventive treatment of calcium oxalate crystal deposition with immortal flowers

Orhan

Onaran

Şen

et al. 2015

Journal of Ethnopharmacology

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“…Reduction in glomerular filtration rate can be an outcome of crystals obstructing the renal passage. 26 This leads to accumulation of significant amount nitrogenous wastes like creatinine and urea. The obvious increase in serum creatinine and urea shows the renal dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Citrus Bioflavonoids Ameliorate Hyperoxaluria Induced Renal Injury and Calcium Oxalate Crystal Deposition in Wistar Rats

Sridharan¹,

Shiju²,

Arya³

et al. 2015

Adv Pharm Bull

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Helichrysum plicatum DC. subsp. plicatum extract as a preventive agent in experimentally induced urolithiasis model

Cited by 31 publications

References 28 publications

Preclinical Evaluation of Antiurolithiatic Activity of Viburnum opulus L. on Sodium Oxalate‐Induced Urolithiasis Rat Model

Preclinical Evaluation of Antiurolithiatic Activity of Viburnum opulus L. on Sodium Oxalate‐Induced Urolithiasis Rat Model

Preventive treatment of calcium oxalate crystal deposition with immortal flowers

Citrus Bioflavonoids Ameliorate Hyperoxaluria Induced Renal Injury and Calcium Oxalate Crystal Deposition in Wistar Rats

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